A5087724919- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Reproductive Health and Contraception
- Atrial Fibrillation Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Cardiovascular Issues in Pregnancy
- Diet and metabolism studies
- Global Cancer Incidence and Screening
- Long-Term Effects of COVID-19
- Blood donation and transfusion practices
- Acute Myeloid Leukemia Research
- Head and Neck Cancer Studies
- Diet, Metabolism, and Disease
Jouf University
2019-2024
Sudan University of Science and Technology
2022
Jazan University
2021
Janaki Medical College
2017
Single-nucleotide polymorphism (SNP) in the promoter region of IL-10 gene can increase susceptibility to tumor development. The current study aimed explore genotypic frequency interleukin-10 (IL-10) rs1800896 newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) and validate whether this SNP is a risk factor for ALL.This case-control was based on subset 154 ALL recruited from Radiation Isotope Center Khartoum (RICK) healthy controls same geographical area. Genomic DNA used...
TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In this study, we evaluated the frequency of rs1800629 (–308 G>A) polymorphism in newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) its correlation age at diagnosis, gender subtype ALL. case control a total 330 individuals were recruited, including 165 ALL, from Radiation Isotope Center Khartoum (RICK) healthy normal controls. was tested through allele-specific polymerase...
Cytokine storm (CS) refers to the spontaneous dysregulated and hyper-activated inflammatory reaction occurring in various clinical conditions, ranging from microbial infection end-stage organ failure. Recently novel coronavirus involved COVID-19 (Coronavirus disease-19) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has been associated with pathological phenomenon of CS critically ill patients. Furthermore, patients suffering are likely have a grave prognosis higher...
Polycystic ovary syndrome (PCOS) is one of the most important contributing factors to infertility. The diagnosis PCOS not an easy procedure, as signs and symptoms are heterogeneous undefined etiology. There only a few published studies that address diagnostic performance anti-Müllerian hormone in sub-Saharan Africa including Sudan.This study aims assess (AMH), luteinizing follicle-stimulating ratio (LH: FSH), total testosterone (TT), prolactin (PRL) levels among PCOS. In addition, we...
Purpose: Glutathione S -transferases (GSTT1 and GSTM1) are instrumental in detoxification process of activated carcinogens. Nucleotide excision repair is carried out by DNA helicase encoded xeroderma pigmentosum group D (XPD) genes aberrations the XPD gene predisposes to increased risk cancer. The present study aimed investigate GSTT1, GSTM1 polymorphisms newly diagnosed chronic myeloid leukemia (CML) patients examine association these with developing CML. Patients Methods: This case–control...
Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous exogenous compounds provide cytoprotective role against reactive species. This study aimed to assess the frequency of GSTT1, GSTM1 polymorphisms in newly diagnosed Sudanese adult patients with acute lymphoblastic leukemia (ALL) evaluate association these age, gender type ALL.This case-control included 128 Sudanese, untreated ALL, aged 18 74 years age-gender matched healthy controls. Deletional GSTT1 genes were genotyped...
Significant efforts have been made to study cancer at the biochemical and cellular level identify factors associated with progression. The aim of this hospital based randomized comparative Nepalese Army Institute Health science was assess in 52 people diagnosed different types 56 normal control persons. Fasting blood samples were analyzed for serum total cholesterol (TC), high density lipoprotein (HDL), triglycerides (TG) low (LDL). We found that parameter TC, TG, VLDL (very lipoprotein),...
In Al-Ahsa, Saudi Arabia, the high consanguinity rates contribute to prevalence of inherited hemoglobinopathies such as sickle cell disease and thalassemia, which frequently require blood transfusions. These transfusions carry risk alloimmunization, necessitating a precise component matching mitigate health risks. Local antigen frequency data is vital for optimizing transfusion practices enhancing safety these medical procedures Al-Ahsa population.
Postmenopausal women tend to have significant changes in lipid profile when compared with premenopausal women. Incidence of cardiovascular disease after menopause believed occur due the plasma levels. This study was conducted estimate and compare serum levels total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol (LDL-c) high-density (HDL-c) among Sudanese pre postmenopausal 94 participant were enrolled this cross-sectional study. 47 post-menopause age 48 - 70 years...
Polycystic ovary syndrome (PCOS) is a prevalent health condition that commonly affects adolescent girls and young women. The purpose of this study was to evaluate the correlation between levels total glutathione (TG), reduced (GSH), superoxide dismutase (SOD), lipid peroxidation, homocysteine with PCOS.This employed cross-sectional case-control design, involving target population 305 Sudanese females. Among them, 205 individuals were categorized as cases, 100 served controls. TG, GSH, SOD,...
Venous thromboembolism (VTE) is one of the major causes pregnancy-related mortality and morbidity. This study aimed to determine frequency factor V Leiden (FVL) prothrombin G20210A polymorphisms measure plasma levels protein C (PC), S (PS) antithrombin (AT) in pregnant women with VTE healthy women. prospective case-control determined frequencies FVL G1691A measured PC, PS AT 198 Allele-specific polymerase chain reaction (ASPCR) was used detect gene mutations. The polymorphism mutations were...
With increasing prevalence of cancer in Saudi Arabia, there is a lack research on the public awareness various types. It important that analysed so early detection types can be achieved, which may improve treatment and recovery processes. purpose this study to investigate leukaemia Arabia. This cross-sectional study, focuses an online survey questionnaire order assess leukaemia, its types, symptoms, risk factors. The using link was forwarded randomly all adult population platforms by...
The prevalence of Hepatitis C viral infection in Egypt is the highest rate world. It a major public health problem Egypt. objective this study was to detect clearance HCV-RNA Egyptian patients who were recommended for combination therapy pyglated interferon α 2a and ribavirin (PEG-interferon/Ribavirin). Ninety-five positive HCV-IgG cases tested at baseline weeks 4, 12, 24, 48 72 treatment with PEG-interferon 2a/Ribavirin. correlations between parameters during after evaluated. Patients...
Introduction The use of tobacco is increasing and broadly spreading throughout the world. It a bad human behavior practiced by people when addicted to nicotine, which causes many harmful diseases1. smoking highest risk factor in progress specific health problems, such as c
Deep vein thrombosis (DVT) is a critical condition and potential cause of mortality morbidity in Africa worldwide with high recurrence rate. The study was designed to assess the roles natural anticoagulants fibrinolytic regulatory factors development DVT Sudanese patients. A case-control conducted Omdurman Teaching Hospital, Khartoum State over period 1 year. enrolled 200 patients diagnosed age-matched gender-matched controls. Demographic data on acquired risk were collected using...
Background: The effective management and choice of appropriate treatment lymphoma subtypes depend on an accurate diagnosis differentiation, which require comprehensive haematology pathology work. Methods: A total 134 cases malignant lymphoma, newly diagnosed between January 2017 to 2020, were selected. For each patient’s samples, complete blood count, immunohistochemistry, morphological evaluation done. Results: Clinical data showed that 81 patients (60.4%) males 53 (39.6%) females. age...
HPV is responsible for over 90% of cervical cancer worldwide. has numerous subtypes with great variety distribution in different geographical regions. Thus, the present study aimed at assessing Human Papillomavirus (HPV) genotypes associated intraepithelial lesions among Saudi women.The current collected smears from 300 women transferred to a cytopathology laboratory between May 2020 and 2021. The studied were referred do Pap smear because gynecologic complaints.Positive testing was...
Cervical intraepithelial neoplasia (CIN) is a type of abnormal cervical epithelial development that can lead to malignancy. Thus, the purpose this study was examine cytological pattern smears from group Saudi women who visited single gynecologic center.From May 2020 2021, 300 were referred cytopathology laboratory and their materials collected. Because concerns, in for Pap smears. As part obligatory investigations conjunction with clinical assessment, smear requested.CIN various grades found...
Background Oral contraceptives are commonly taken by women and known to increase the risk of venous thromboembolism (VTE). Objective The aim this study was investigate association between oral contraceptive use natural anticoagulants, that is, protein C (PC), S (PS), antithrombin in pregnant with deep vein thrombosis (DVT). Materials methods This case–control conducted on 330 women, cases 165 (who used contraceptives) controls did not contraceptives). levels PC, PS, were measured compared...
PCC25 (2,865 ± 334 mL) had the highest total BL post-injury, with 100% and 37.5% mortality, respectively.Although was significantly less both in PCC50 (1,855 372 ADA (1,123 197 groups, showed reduction due to a faster onset of reversal at 60 min postinury (Fig 1).While 4F-PCC recovered peak height (PK) endogenous thrombin potential (ETP) dose-dependently over sustained period time, shortened lag time restored PK 2).Postmortem histopathology revealed no thromboembolic complications any...
Overweight and obesity prevalence continues to increase worldwide growing epidemic health problems. Obesity imposes a significant effect on liver functions that may be associated with substantial risk factor for the development of several non-communicable diseases, considerable disability, premature death. To estimate compare serum activity ALT, ALP, GGT among healthy obese Sudanese individuals. Materials methods: total number 80 participants were enrolled in this cross-sectional study, they...