A5062876550- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- MicroRNA in disease regulation
- Medicinal Plants and Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Environmental Toxicology and Ecotoxicology
- Diet, Metabolism, and Disease
- Medicinal Plant Research
- RNA and protein synthesis mechanisms
- Phytochemicals and Medicinal Plants
- Laser Applications in Dentistry and Medicine
- Food Science and Nutritional Studies
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Medicinal Plants and Neuroprotection
- Natural Compounds in Disease Treatment
- Circular RNAs in diseases
- Antioxidants, Aging, Portulaca oleracea
- Adenosine and Purinergic Signaling
- Natural Antidiabetic Agents Studies
Alexandria University
2011-2025
King Faisal University
2024-2025
Bibliotheca Alexandrina
2017
Institut Interdisciplinaire de Neuroscience
2011
Centre National de la Recherche Scientifique
2011
Université de Bordeaux
2011
Multiple sclerosis (MS) is characterized as a chronic inflammatory demyelinating neurodegenerative disorder that leads to the deterioration of myelin sheath and loss axons. Betaine, trimethylglycine compound, recognized for its ability penetrate blood-brain barrier (BBB) exhibits properties are antioxidant, anti-inflammatory, neuroprotective. The cuprizone (CPZ) model serves an effective tool investigating processes demyelination remyelination associated with MS. In our research, we examined...
Diabetic peripheral neuropathy (DPN) is a significant complication of diabetes with limited effective therapeutic options. Sodium alginate (SA), natural polysaccharide from brown algae, has demonstrated health benefits, however, whether it can treat streptozotocin (STZ)-induced DPN remains unclear. The present experiment aimed to test the preventive role SA on STZ-induced in rats and explored possible mechanisms. rat model was established by intraperitoneal injection single dose 40 mg/kg...
Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental characterized by hyperactivity, inattention, and impulsivity that often persist until adulthood. Frequent comorbid disorders accompany ADHD two thirds of children diagnosed with also suffer from behavioural alteration sensory processing. We recently the comorbidity between ADHD-like symptoms pain sensitisation in pharmacological mouse model ADHD, we demonstrated implication anterior cingulate cortex...
Tauroursodeoxycholic acid (TUDCA) is approved for the treatment of liver diseases. However, antihyperglycemic effects/mechanisms TUDCA are still less clear. The present study aimed to evaluate antidiabetic action in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. Fifteen adult Wistar albino male rats were randomly divided into three groups (n = five each): control, diabetic (STZ), and STZ+TUDCA. results showed that significantly reduced blood glucose, HbA1c%, HOMA-IR as...
Ulcerative colitis (UC) is a gastrointestinal inflammatory disease with multifactorial pathophysiology. This study aims to investigate the immunomodulatory effect of Portulaca oleracea leaf ethanolic extract (POE) on acetic acid (AA)-induced UC in mice. Experimental animals received oral doses POE (200 mg/kg for 7 days) after an induction by intrarectal AA administration. In mice AA-induced treated POE, results revealed significant modulation body weight and colon length. Moreover, treatment...
Diabetes mellitus is a metabolic disorder associated with various complications encompassing male reproductive dysfunction. The present study aimed to investigate the therapeutic potential of biologically active Lepidium sativum seed oil (LSO) against testicular dysfunction streptozotocin (STZ)-induced diabetes. Male adults (n = 24) were divided into four groups: control, LSO-administered, diabetic (D), and LSO-treated (D+LSO) groups. LSO was extracted from L. seeds, its chemical composition...
Epigallocatechin 3-gallate (EGCG) is a natural polyphenolic antioxidant in green tea leaves with well-known health-promoting properties. However, the influence of EGCG on chronic animal model depression remains to be fully investigated, and details molecular cellular changes are still unclear. Therefore, present study aimed investigate antidepressant effect mice subjected unpredictable mild stress (CUMS). After eight consecutive weeks CUMS, were treated (200 mg/kg b.w.) by oral gavage for...
Improving response rates in colorectal cancer (CRC) is an urgent clinical need. This study aimed to explore the synergistic action of Lebanese rosemary essential oil (REO) and 5-fluorouracil (5-FU) HCT116 CRC cells.
HIGHLIGHTS Blockade of dopamine D1 receptors in ACC suppressed instrumental learning when overt responding was required.Covert through observation not impaired.After treatment with a antagonist, recovered but the rat's pretreatment level effort tolerance.ACC is necessary for acquisition task-relevant cues during learning, regulates energy expenditure and based decision. Dopamine activity anterior cingulate cortex (ACC) essential various aspects behavior, including decision making. To...
The growing prevalence of aged sleep-deprived nations is turning into a pandemic state. Acute sleep deprivation (SD) accompanies aging, changing the hippocampal cellular pattern, neurogenesis pathway expression, and aggravating cognitive deterioration. present study investigated ability Near Infra Red (NIR) light laser to ameliorate impairment induced by SD in young senile rats. Wistar rats ≤ 2 months (young) ≥ 14 (senile) were for 72 h with or without transcranial administration NIR 830 nm....
Environmental variability has a great impact on the processes of ecological organization. Local variation probably accounts for population in death rate. Marine parasites are importance. Incorporating environmental into theories life histories better understanding how factors influence physiology and resulting individuals. Adult Oreochromis auruis were collected from, El Behiara, Egypt. The concentration Pb, Cu, Cd have been detected biota samples from Behara, plenty heavy metal fish was...
Age-related hearing loss (AHL) is the most common sensory disorder of aged population. Currently, one important sources experimental medicine for AHL medicinal plants. This study performed first investigation effect thymoquinone (TQ), a potent antioxidant, on AHL. Here, we used inbred C57BL/6J mice (B6 mice) as successful model early onset The behavioral assessment revealed that injection high dose TQ (40 mg/kg;
Background: Inflammatory pain is the most common type of chronic pain, and it rapidly becoming a global health problem. Ginkgo biloba (EGb761) natural plant that contains several bioactive components with antioxidant free radical scavenging properties. However, its underlying mechanism in inflammatory remains unclear. The aim this study was to assess effects mechanisms EGb761 on complete Freund's adjuvant (CFA)-induced model rats.