A5055501065- Effects and risks of endocrine disrupting chemicals
- Microplastics and Plastic Pollution
- Marine Biology and Environmental Chemistry
- Neuroscience and Neuropharmacology Research
- Vitamin D Research Studies
- Neurological Disease Mechanisms and Treatments
- Toxic Organic Pollutants Impact
- Stress Responses and Cortisol
- Medicinal Plant Extracts Effects
- Electrolyte and hormonal disorders
- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- Sleep and Wakefulness Research
- Arsenic contamination and mitigation
- Folate and B Vitamins Research
- Pesticide Exposure and Toxicity
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- Phytoestrogen effects and research
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Heavy Metal Exposure and Toxicity
- Medicinal Plants and Neuroprotection
- Chronic Kidney Disease and Diabetes
- Biochemical effects in animals
Alexandria University
2019-2025
Abstract Epilepsy is one of the most common serious brain disorders, affecting about 1% population all over world. Ginkgo biloba extract (GbE) and L-carnitine (LC) reportedly possess antioxidative activity neuroprotective potential. In this report, we investigated possible protective therapeutic effects GbE LC against pentylenetetrazol (PTZ)-induced epileptic seizures in rat hippocampus hypothalamus. Adult male albino rats were equally divided into eight groups: control, (100 mg/kg), (300...
Multiple sclerosis (MS) is characterized as a chronic inflammatory demyelinating neurodegenerative disorder that leads to the deterioration of myelin sheath and loss axons. Betaine, trimethylglycine compound, recognized for its ability penetrate blood-brain barrier (BBB) exhibits properties are antioxidant, anti-inflammatory, neuroprotective. The cuprizone (CPZ) model serves an effective tool investigating processes demyelination remyelination associated with MS. In our research, we examined...
Bisphenol A (BPA), a common plastic additive, has been demonstrated mechanistically to be potential endocrine disruptor and affect variety of body functions in organisms. Although previous research shown that BPA is toxic aquatic organisms, the mechanism neurotoxic effects marine bivalves remains unknown. The current study aimed elucidate when administered at different concentrations (0.25, 1, 2, 5 µg/L) for twenty-eight days ganglia bivalve model, Mediterranean mussel (Lithophaga...
Bisphenol A (BPA) is an endocrine disruptor to which humans are often subjected during daily life. This study aimed investigate the ameliorative effect of astragaloside IV (ASIV) or saponins extracted from Astragalus spinosus (A. spinosus) against DNA damage and neurotoxic effects induced by BPA in prefrontal cortex (PFC), hippocampal striatal brain regions developing male rats.Juvenile PND20 (pre-weaning; age 20 days) Sprague Dawley rats were randomly equally divided into four groups:...
Abstract Bisphenol A (BPA), a common endocrine-disrupting chemical, is found in wide range of home plastics. Early-life BPA exposure has been linked to neurodevelopmental disorders; however, the link between neuroinflammation, pyroptosis, and development psychiatric disorders rarely studied. The current study attempted investigate toxic effect on inflammatory microglial activation markers, as well behavioral responses, brains male rats dose- age-dependent manner. Early began postnatal day...
Synthetic organic insecticides such as pyrethroids, organophosphates, neonicotinoids, and others have the potential to disrupt ecosystems are often toxic humans. Thiamethoxam (TMX), a neonicotinoid insecticide , is widely used with neurotoxic potential. L-Carnitine (LC) regarded "gatekeeper" in charge of allowing long-chain fatty acids into cell mitochondria. LC an endogenous chemical that renowned for its prospective biological activity addition role energy metabolism. This study...
Free radicals are involved in neurodegenerative disorders such as ischemia and aging. Treatments with Spirulina have been shown to reduce changes animals. The present study has designed examine the potential neuroprotective effects of platensis (Sp.) against AlCl3-induced neurotoxicity different regions brain (cerebral cortex, hippocampus hind brain) rats. AlCl3 caused significant increase thiobarbituric acid-reactive substances, tumor necrosis factor-a aluminium concentration, while...
Abstract Arsenic is associated with various neurological disorders, notably affecting memory and cognitive functions. The current study examined the protective effects of vitamin D3 (Vit. D3) in countering oxidative stress, neuroinflammation apoptosis induced by sodium arsenite (SA) cerebral cortex rats. Male Wistar rats were subjected to a daily oral administration (NaAsO2, SA) at dosage 5 mg/kg, along 500 IU/kg Vit. D3, combination both substances for four weeks. results indicated that...
Abstract Exposure to bisphenol A (BPA) contributes neurological disorders, but the underlying mechanisms are still not completely understood. We studied neurotoxic effect of BPA and how it promotes inflammation alteration in neurotransmission synthesis, release transmission. This study was also designed investigate neuroprotective grape seed proanthocyanidins (GSPE) against BPA-induced neurotoxicity rats. Rats were equally divided into 4 group with 7 rats each as follows: control group, GSPE...