A5101793470- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Research in Cotton Cultivation
- Plant-Microbe Interactions and Immunity
- Plant Molecular Biology Research
- Plant Disease Resistance and Genetics
- Influenza Virus Research Studies
- Chromosomal and Genetic Variations
- Viral Infections and Vectors
- Insect Resistance and Genetics
- Entomopathogenic Microorganisms in Pest Control
- Mosquito-borne diseases and control
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- Insect symbiosis and bacterial influences
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Plant nutrient uptake and metabolism
- HIV Research and Treatment
- Plant pathogens and resistance mechanisms
- Vector-Borne Animal Diseases
- Transgenic Plants and Applications
- Cocoa and Sweet Potato Agronomy
- Cytokine Signaling Pathways and Interactions
- Cancer therapeutics and mechanisms
Nanjing Agricultural University
2009-2023
Wageningen University & Research
2019-2022
Graduate School Experimental Plant Sciences
2019-2022
Kunming University of Science and Technology
2021
Northwest University
2021
Deyang Stomatological Hospital
2020
Hangzhou Normal University
2018-2019
Iowa State University
2012
University of California System
2011
Huazhong Agricultural University
2009-2010
Plant viruses move through plasmodesmata to infect new cells. The plant endoplasmic reticulum (ER) is interconnected among cells via the ER desmotubule in plasmodesma across cell wall, forming a continuous network throughout entire plant. This continuity unique plants and has been postulated serve as platform for intercellular trafficking of macromolecules. In present study, contribution membrane transport system NSm movement protein Tomato spotted wilt tospovirus (TSWV) investigated. We...
Broadly neutralizing antibodies targeting the stalk region of influenza A virus (IAV) hemagglutinin (HA) are effective in blocking infection both vitro and vivo. The highly conserved epitopes recognized by these critical for membrane fusion function HA therefore less likely to be permissive mutational escape. Here we report three resistant viruses A/Perth/16/2009 strain that were selected presence a broadly stalk-binding antibody. harbor different mutations stalk: (1) Gln387Lys; (2)...
Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested vitro and protects mice against lethal challenge of when administered 72 h post infection. demonstrates superior therapeutic benefit over Tamiflu has additive antiviral effect combination with Tamiflu. binds conserved epitope vestigial esterase domain hemagglutinin (HA) blocks...
A novel red-pigmented, Gram-negative, motile, fluorescent, rod-shaped strain, DZ0503SBS1T, with a single lateral flagellum, was isolated from the intestine of nematode Heterorhabditidoides chongmingensis. Comparative 16S rRNA gene sequence analysis indicated that strain is member genus Serratia, sharing highest similarities Serratia marcescens subsp. sakuensis JCM 11315T (99.8 %), S. DSM 30121T (99.5 %) and ureilytica LMG 22860T (98.3 %). Similarities between rpoB DZ0503SBS1T those 11315T,...
A novel red-pigmented, Gram-negative, motile, fluorescent, rod-shaped strain, DZ0503SBS1T, with a single lateral flagellum, was isolated from the intestine of nematode Heterorhabditidoides chongmingensis. Comparative 16S rRNA gene sequence analysis indicated that strain is member genus Serratia, sharing highest similarities Serratia marcescens subsp. sakuensis JCM 11315T (99.8 %), S. DSM 30121T (99.5 %) and ureilytica LMG 22860T (98.3 %). Similarities between rpoB DZ0503SBS1T those 11315T,...
MHAA4549A is a human immunoglobulin G1 (IgG1) monoclonal antibody that binds to highly conserved epitope on the stalk of influenza A hemagglutinin and blocks hemagglutinin-mediated membrane fusion in endosome, neutralizing all known strains. Pharmacokinetics (PK) its related antibodies were determined DBA/2J Balb-c mice at 5 mg/kg cynomolgus monkeys 100 as single intravenous dose. Serum samples analyzed for concentrations using an ELISA PK was evaluated WinNonlin software. Human profiles...
Gossypium australe F. Mueller (2n = 2x 26, G2 genome) possesses valuable characteristics. For example, the delayed gland morphogenesis trait causes cottonseed protein and oil to be edible while retaining resistance biotic stress. However, lack of gene sequences their alternative splicing (AS) in G. remain unclear, hindering explore species-specific biological morphogenesis.Here, we report first sequencing full-length transcriptome Australian wild cotton species, australe, using Pacific...
Guanine nucleotides are required for growth and viability of cells due to their structural role in DNA RNA, regulatory roles translation, signal transduction, cell division. The natural antibiotic mycophenolic acid (MPA) targets the rate-limiting step
Tomato spotted wilt virus (TSWV) is one of the most devastating plant viruses and often causes severe crop losses worldwide. Generally, mature plants become more resistant to pathogens, known as adult resistance. In this study, we demonstrated a new phenomenon involving developmentally regulated susceptibility Arabidopsis thaliana TSWV. We found that susceptible TSWV mature. Most young 3-week-old were not infected by Infection in 4-, 5-, 6-week-old increased from 9%, 21%, 25%, respectively,...
Abstract Background Nonhost resistance (NHR) provides immunity to all members of a plant species against isolates microorganism that is pathogenic other species. Three Arabidopsis thaliana PEN (penetration deficient) genes, PEN1, 2 and 3 have been shown provide NHR the barley pathogen Blumeria graminis f. sp . hordei at prehaustorial level. pen1-1 mutant lacking PEN1 gene penetrated by hemibiotrophic oomycete Phytophthora sojae, causal organism root stem rot disease in soybean. We...
Arsenic (As) contamination in subsoil and groundwater is a big problem, especially many South-East Asian countries. As staple crop growing under flooded condition these areas, rice (Oryza sativa L.) becomes threat to human health through the food chain since highly accumulated grains. Thus, reducing accumulation molecular breeding identification of varieties with low content are pressing issues. However, current understanding on mechanism stress response still limited for rice. In this...
Most cytoplasmic-replicating negative-strand RNA viruses (NSVs) initiate genome transcription by cap snatching. The source of host mRNAs from which the cytoplasmic NSVs snatch capped-RNA leader sequences has remained elusive. Earlier reports have pointed towards cytoplasmic-RNA processing bodies (P body, PB), although several questions unsolved. Here, nucleocapsid (N) protein plant- and animal-infecting members order Bunyavirales, in casu Tomato spotted wilt virus (TSWV), Rice stripe (RSV),...
Tomato spotted wilt virus (TSWV) is a negative-stranded RNA that infects hundreds of plant species, causing great economic loss. Infected Arabidopsis thaliana plants develop symptoms including chlorosis and wilt, which can lead to cell death. From 9 15 days after TSWV infection, progress through three-stage process appearance, severity, In this study, deep sequencing technology was first used explore gene expression in response infection model A. at different symptom development stages. We...
Antiviral RNA silencing/interference (RNAi) of negative-strand (-) plant viruses (NSVs) has been studied less than for single-stranded, positive-sense (+)RNA viruses. From the latter, genomic and subgenomic mRNA molecules are targeted by RNAi. However, strands from NSVs generally wrapped tightly within viral nucleocapsid (N) protein to form ribonucleoproteins (RNPs), core unit replication, transcription movement. In this study, targeting NSV tospoviral antiviral RNA-induced silencing...
ObjectiveTo study correlations between expression of microRNA-146a (miR-146a) and immunoglobulin inflammatory cytokines in serum patients with Guillain–Barré syndrome (GBS).MethodsEighty-four GBS were selected as the experimental group 50 healthy individuals controls. Reverse transcription-PCR was used to detect miR-146a peripheral blood all participants. Immunoturbidometric assay immunoglobulins (Ig)G, IgA, IgM The levels interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor...
Gossypium arboreum (2 n =2 x =26, A 2 ), the putative progenitor of t -subgenome hirsutum =4 =52, AD), is a repository genes interesting that have been eliminated during evolution/domestication G. . However, its valuable remain untapped so far due to species isolation. Here, using synthetic amphiploid (AADDA ) previously reported, we developed set 289 chromosome segment introgression lines (ILs) in by expanding backcrossing population and through precise marker-assisted selection (MAS)...