A5075324491- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Adaptive Control of Nonlinear Systems
- Control and Dynamics of Mobile Robots
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Guidance and Control Systems
- Cardiovascular Syncope and Autonomic Disorders
- Plant and Fungal Interactions Research
- Receptor Mechanisms and Signaling
- Plant Virus Research Studies
- Advanced Control Systems Optimization
- Stability and Control of Uncertain Systems
- Plant-Microbe Interactions and Immunity
- Robotic Path Planning Algorithms
- Myofascial pain diagnosis and treatment
- Research in Cotton Cultivation
- Pain Mechanisms and Treatments
- Fish Ecology and Management Studies
- Inertial Sensor and Navigation
- Hereditary Neurological Disorders
- Fluid Dynamics and Turbulent Flows
- Musculoskeletal pain and rehabilitation
- Aerospace and Aviation Technology
Syracuse University
2019-2024
Beth Israel Deaconess Medical Center
2014-2024
Harvard University
2010-2024
Xinjiang Production and Construction Corps
2024
University of Michigan–Ann Arbor
2024
University of Colorado Anschutz Medical Campus
2023
Sanming Agricultural Science Research Institute
2023
Hadassah Medical Center
2020
Beth Israel Deaconess Hospital
2019
Tel Aviv University
1998-2007
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder caused by the abnormal accumulation of α-synuclein in nervous system. Clinical features include autonomic and motor dysfunction, which overlap with those Parkinson disease (PD), particularly at early stages. There an unmet need for accurate diagnostic prognostic biomarkers MSA and, specifically, critical to distinguish from other synucleinopathies, PD. The purpose study was develop unique cutaneous pathologic signature...
Importance Finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (Parkinson disease [PD], dementia with Lewy bodies [DLB], multiple system atrophy [MSA], and pure autonomic failure [PAF]) is an urgent unmet need. Immunohistochemical detection of cutaneous phosphorylated α-synuclein may be sensitive specific clinical test diagnosis synucleinopathies. Objective To evaluate positivity rate deposition in patients PD, DLB, MSA, PAF. Design, Setting,...
To develop a cutaneous biomarker for Parkinson disease (PD).Twenty patients with PD and 14 age- sex-matched control subjects underwent examinations, autonomic testing, skin biopsies at the distal leg, thigh, proximal thigh. α-Synuclein deposition density of intraepidermal, sudomotor, pilomotor nerve fibers were measured. was normalized to fiber (the α-synuclein ratio). Results compared examination scores function testing.Patients had sensory neuropathy characterized by loss intraepidermal (p...
To evaluate a novel method to quantify the density of nerve fibers innervating sweat glands in healthy control and diabetic subjects, compare results an unbiased stereologic technique, identify relationship standardized physical examination patient-reported symptom scores.Thirty 64 subjects had skin biopsies performed at distal leg proximal thigh. Nerve glands, stained with PGP 9.5, were imaged by light microscopy. Sweat gland fiber (SGNFD) was quantified manual morphometry. As gold...
Maternal smoking during pregnancy has been associated with adverse effects on respiratory health. Whereas the epidemiologic link is incontrovertible, mechanisms responsible for this association are still poorly understood. Although cigarette smoke many toxic constituents, nicotine, major addictive component in smoke, may play a more significant role than previously realized. The objectives of study were to determine whether exposure nicotine prenatally leads alterations pulmonary function...
To determine the diagnostic discrimination of cutaneous α-synuclein deposition in individuals with Parkinson disease (PD) and without autonomic dysfunction on testing, early late stages disease, short long duration.Twenty-eight participants PD 23 control were studied by skin biopsies at multiple sites, function disease-specific scales.Skin provide >90% sensitivity specificity to distinguish from across all sites quantification either pilomotor or sudomotor deposition. All have significantly...
Peripheral sudomotor dysfunction is present in many peripheral neuropathies, but structural assessments of fibers rarely occur. We evaluated 36 diabetic and 72 healthy control subjects who underwent detailed neurologic examinations punch skin biopsies. Physical exam findings were quantified by neuropathy impairment score the lower limb. Skin biopsies intraepidermal nerve fiber density (IENFD) sweat gland (SGNFD) a manual, automated, semiquantitative method. The automated manual SGNFD...
Objective To define the neuropathology, clinical phenotype, autonomic physiology and differentiating features in individuals with neuropathic non-neuropathic postural tachycardia syndrome (POTS). Methods Twenty-four subjects POTS 10 healthy control had skin biopsy analysis of intra-epidermal nerve fiber density (IENFD), quantitative sensory testing (QST) testing. Subjects completed quality life, fatigue disability questionnaires. were divided into POTS, defined by abnormal IENFD small...
Background and Purpose —There is a growing interest in the use of genetic markers differential diagnosis dementia. In current study we examined usefulness risk factors for vascular disease as dementia (VD). Methods —The groups included 41 patients with VD, 49 Alzheimer’s type, 40 age-matched control subjects without These were genotyped disease–associated polymorphisms genes coding methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), factor V Leiden (FVL), common...
Abstract Objective To determine the effects of topical application capsaicin on cutaneous autonomic nerves. Methods Thirty‐two healthy subjects underwent occlusive 0.1% cream (or placebo) for 48 hours. Subjects were followed 6 months with serial assessments sudomotor, vasomotor, pilomotor, and sensory function simultaneous assessment innervation through skin biopsies. Results There reductions in capsaicin‐treated ( p < 0.01 vs. placebo). Sensory declined more rapidly than function,...
The detection of cutaneous phosphorylated alpha-synuclein (P-syn) in patients with Parkinson’s disease (PD) has ranged from 30% to 100% across different studies. We hypothesize that part the variability P-syn is due methodological differences using sections tissue thickness. Three skin biopsies were obtained 29 individuals PD and 21 controls. Tissues cut into 10-, 20-, 50-µm-thick double-stained protein gene product (PGP) 9.5 P-syn. quantified deposition without PGP sweat glands, pilomotor...
SUMMARY Alternative splicing (AS) of pre‐mRNAs increases the diversity transcriptome and proteome plays fundamental roles in plant development stress responses. However, prevalent changes AS events regulating mechanisms plants response to pathogens remain largely unknown. Here, we show that are an important mechanism conferring cotton immunity Verticillium dahliae ( Vd ). GauSR45a , encoding a serine/arginine‐rich RNA binding protein, was upregulated expression underwent infection Gossypium...
Neuronal acetylcholine nicotinic receptors (nAChR) are composed of 12 subunits (α2‐10, β2‐4), which α3, α5, α7, β2 and β4 known to exist in the autonomic nervous system (ANS). α5 possess unique biophysical pharmacological properties. The present study was undertaken examine functional role properties nAChR ANS using mice lacking (α5‐/‐). These grew normal size showing no obvious physical or neurological deficit. They also showed normality thermoregulation, pupil resting heart rate under...
Abstract Objective To determine the sensitivity and specificity of cutaneous amyloid deposition in relation to patient‐reported measures earliest disease stage hereditary ATTR amyloidosis (ATTRv). Methods In a cross‐sectional study, we analyzed 88 individuals with TTR mutations, 47 whom were without clinically evident neuropathy, 12 healthy controls, 13 controls diabetes. All participants' neuropathy symptoms signs assessed using validated patient clinician‐reported 3‐mm skin punch biopsies...
Confocal imaging uses immunohistochemical binding of specific antibodies to visualize tissues, but technical obstacles limit more widespread use this technique in the peripheral nerve tissue. These include same-species antibody cross-reactivity and weak fluorescent signals individual co-localized antigens. The aims study were develop new techniques for fibers. Three-millimeter punch skin biopsies healthy individuals fixed, frozen, cut into 50-µm sections. Tissues stained with a variety...
A framework for autonomous waypoint planning, trajectory generation through waypoints, and tracking multi-rotor unmanned aerial vehicles (UAVs) is proposed in this work. Safe effective operations of these UAVs a problem that demands obstacle avoidance strategies advanced planning control schemes stability energy efficiency. To address problem, two-level optimization strategy used generation, then the tracked stable manner. The given here consists following components: (a) deep reinforcement...
Gossypium raimondii (2n=2x=26, D5), an untapped wild species, is the putative progenitor of D-subgenome G. hirsutum (2n=4x=52, AD1), extensively cultivated species. Here, we developed a (recipient)-G. (donor) introgression population to exploit favorable QTLs/genes and mapped potential quantitative trait loci (QTLs) from cotton The consists 256 lines with rate 52.33% genome raimondii. range segment length was 0.03-19.12 Mb, average 1.22 Mb. coverage total fragments 386.98 Mb Further...
Neuronal nicotinic acetylcholine receptors (nAChR) are composed of 12 subunits (α2–α10 and β2–β4), which play the central role in autonomic transmission. β4 abundantly expressed ganglia, forming binding sites ion channels with α3 or α5 as pentameric receptors. To investigate physiological pharmacological properties we measured functions knockout mice lacking nAChR subunit (β4<sup>−/−</sup>) wild-type mice. β4<sup>−/−</sup> had an attenuated bradycardiac response to high frequency (60...
Autonomous trajectory generation in a complex environment is challenging task for multi-rotor unmanned aerial vehicles (UAVs), which have high maneuverability three-dimensional motion. Safe and effective operations these UAVs demand obstacle avoidance strategies advanced planning control schemes stability energy efficiency. To solve those problems one framework analytically extremely when the UAV needs to fly large distance environment. address this challenge, two-level optimization strategy...