A5048695146- DNA Repair Mechanisms
- Topic Modeling
- Antibiotic Resistance in Bacteria
- Retinal Development and Disorders
- Bacterial Genetics and Biotechnology
- Sports injuries and prevention
- Advanced Chemical Sensor Technologies
- Sports Performance and Training
- Pregnancy and preeclampsia studies
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- MicroRNA in disease regulation
- Sport Psychology and Performance
- Protein Kinase Regulation and GTPase Signaling
- Natural Language Processing Techniques
- Tryptophan and brain disorders
- Chromosomal and Genetic Variations
- Birth, Development, and Health
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- CRISPR and Genetic Engineering
- Speech Recognition and Synthesis
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cellular transport and secretion
Guangzhou Medical University
2023-2025
École Polytechnique Fédérale de Lausanne
2024
Northeastern University
2024
Universiti Putra Malaysia
2023
University of California, San Diego
2021-2022
Pediatric sepsis is a complex and life-threatening condition characterized by organ failure due to an uncontrolled immune response infection. Recent studies suggest that ferroptosis, newly identified form of programmed cell death, may play role in progression. However, the specific mechanisms ferroptosis pediatric remain unclear. In this study, we analyzed microarray datasets from healthy blood samples identify ferroptosis-associated genes. A protein-protein interaction (PPI) network...
Preeclampsia (PE) is the primary cause of perinatal maternal-fetal mortality and morbidity. The exact molecular mechanisms PE pathogenesis are largely unknown. This study aims to identify hub genes in explore their potential regulatory network.
Timely completion of eukaryotic genome duplication requires coordinated DNA replication initiation at multiple origins. Replication begins with the loading Mini-Chromosome Maintenance (MCM) complex, proceeds by activation Cdc45-MCM-GINS (CMG) helicase, and ends CMG removal after chromosomes are fully replicated. Post-translational modifications on MCM associated factors ensure an orderly transit these steps. Although mechanisms partially understood, regulated is not, leaving incomplete...
Protein sumoylation, especially when catalyzed by the Mms21 SUMO E3 ligase, plays a major role in suppressing duplication-mediated gross chromosomal rearrangements (dGCRs). How targets its substrates cell is insufficiently understood. Here, we demonstrate that Esc2, protein with SUMO-like domains (SLDs), recruits Ubc9 conjugating enzyme to specifically facilitate Mms21-dependent sumoylation and suppress dGCRs. The D430R mutation Esc2 impairs binding causes synergistic growth defect...
Abstract Despite the soaring popularity of e‐cigarettes among teenagers and young adults, our understanding full extent their health hazards have remained limited. This is due to vast complexities e‐cigarette aerosols difficulty in characterisation. Conventional mass spectrometry methods analysis, though pioneering driving political medical discourse, been limited capabilities uncover all compounds its emissions prominent limitations experimental setup. To overcome this major hurdle, we...