A5004655343- Neurobiology and Insect Physiology Research
- Posttraumatic Stress Disorder Research
- Insect Utilization and Effects
- Gallbladder and Bile Duct Disorders
- Migration, Health and Trauma
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Functional Brain Connectivity Studies
- Animal Behavior and Reproduction
- Child Abuse and Trauma
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Neurological disorders and treatments
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Colorectal Cancer Screening and Detection
- Traumatic Brain Injury Research
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Trauma and Emergency Care Studies
- Pain Management and Treatment
- Physiological and biochemical adaptations
- Cancer Risks and Factors
- Invertebrate Immune Response Mechanisms
- Extracellular vesicles in disease
New York University
2016-2025
Stanford University
2024-2025
Chongqing Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Dalian Medical University
2023-2024
NYU Langone Health
2016-2022
Sir Run Run Shaw Hospital
2003-2021
Zhejiang University
2003-2021
Anhui Medical University
2017
Anhui Provincial Hospital
2017
Significance The central nervous system monitors reduction in metabolic state and promotes feeding foraging response. While behavior has been extensively studied, the regulation of remains largely unknown. In this study, we show that starvation-induced hyperactivity adult fruit flies resembled activity. We also found octopamine, insect counterpart vertebrate norepinephrine, was crucial for foraging. further showed octopamine not required changes feeding, suggesting independent regulations...
A timely determination of the risk post-traumatic stress disorder (PTSD) is a prerequisite for efficient service delivery and prevention. We provide estimate tool allowing calculation individuals' PTSD likelihood from early predictors. Members International Consortium to Predict (ICPP) shared individual participants' item-level data ten longitudinal studies civilian trauma survivors admitted acute care centers in six countries. Eligible participants (N=2,473) completed an initial clinical...
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective sources ensure dietary amino acid plays a critical role in homeostasis. By using quantitative feeding assay, we show that three acids, L-glutamate (L-Glu), L-alanine (L-Ala) L-aspartate (L-Asp), but not their D-enantiomers or other 17 natural L-amino acids combined, rapidly promote food consumption fruit fly Drosophila melanogaster. This feeding-promoting effect independent mating...
Posttraumatic stress disorder (PTSD) is frequently associated with depression and anxiety, but the nature of relationship unclear. By removing mood anxiety diagnostic criteria, 11th edition International Classification Diseases (ICD-11) aims to delineate a distinct PTSD phenotype. We examined effect implementing ICD-11 criteria on rates codiagnosed in survivors recent PTSD.
Chemotherapy is the main treatment for human cancers including gastric cancer.However, in response to chemotherapeutic drugs, tumor cells can develop drug resistance by reprogramming intracellular metabolic and epigenetic networks maintain their intrinsic homeostasis.Previously, we have established cisplatin-resistant cancer as a resistant model, elucidated XRCC1 core DNA repair mechanism of resistance.This study investigated regulation lysine demethylase 5B (KDM5B) resistance.We found that...
Chemotherapy is one of the most important approaches for treatment various cancers.However, tumor cells often develop resistance to chemotherapeutic drugs.The microenvironment reconstituted by cytokines secreted from immune was recently found play roles in affecting therapeutic response cells.Herein, we reported that can secrete autocrine confer chemoresistance inactivating proapoptotic autophagy.Through cytokine screening, drug resistant cancer more CCL2 than sensitive cells.Such could not...
Food intake of the adult fruit fly Drosophila melanogaster, an intermittent feeder, is attributed to several behavioral elements including foraging, feeding initiation and termination, food ingestion. Despite development various assays in flies, how each these elements, particularly ingestion, regulated remains largely uncharacterized. To this end, we have developed a manual (MAFE) assay that specifically measures ingestion individual completely independent other elements. This reliably...
Abstract Background Projected changes to post-traumatic stress disorder (PTSD) diagnostic criteria in the upcoming International Classification of Diseases (ICD)-11 may affect prevalence and severity identified cases. This study examined differences rates, severity, overlap diagnoses using ICD-10 ICD-11 PTSD during consecutive assessments recent survivors traumatic events. Methods The sample comprised 3863 events, evaluated 11 longitudinal studies PTSD. rules were applied...
Sensing satiety is a crucial survival skill for all animal species including human. Despite the discovery of numerous neuromodulators that regulate food intake in Drosophila, mechanism sensing remains largely elusive. Here, we investigated how neuropeptidergic circuitry conveyed state to influence flies' consumption. Drosophila tackykinin (DTK) and its receptor TAKR99D were identified an RNAi screening as feeding suppressors. Two pairs DTK+ neurons fly brain could be activated by elevated...
Sweet taste perception, a critical aspect of the initiation feeding behavior, is primarily regulated by an animal’s internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing hence behavior. While mating experience known to induce changes, its broader impact on other innate behaviors remains largely uncharacterized. In this study, we demonstrated that failure male fruit flies suppressed sweet...
Sweet taste perception, a critical aspect of the initiation feeding behavior, is primarily regulated by an animal’s internal metabolic state. However, non-metabolic factors, such as motivational and emotional states, can also influence peripheral sensory processing hence behavior. While mating experience known to induce changes, its broader impact on other innate behaviors remains largely uncharacterized. In this study, we demonstrated that failure male fruit flies suppressed sweet...
There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) related significant in renal cancer risk. We sought clarify DRRD was associated with reduced of US population.A population-based cohort 101,755 American adults identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. A score calculated assess this dietary pattern, where increased scores indicated greater adherence. The relationship between assessed based on...
AIM:To evaluate the safety and feasibility of biliary tract reoperation by laparoscopy for patients with retained or recurrent stones who failed in endoscopic sphincterotomy. METHODS:A retrospective analysis data obtained from attempted laparoscopic 39 a single institution was performed, examining open conversion rates, operative times, complications, hospital stay. RESULTS:Out cases, 38 (97%) completed laparoscopy, 1 required to operation because difficulty exposing common bile duct.The...
Background: Understanding the development of post-traumatic stress disorder (PTSD) is a precondition for efficient risk assessment and prevention planning. Studies to date have been site sample specific. Towards developing generalizable models PTSD prediction, International Consortium Predict (ICPP) compiled data from 13 longitudinal, acute-care based studies performed in six different countries.Objective: The objectives this study were describe ICPP's approach pooling harmonization, present...
AIM:Choledocholithiasis is present in 5 to 10 percent of patients who have cholelithiasis.In the area laparoscopic cholecystectomy (LC), common bile duct exploration (LCBDE) and intraoperative endoscopic sphi ncteroto my (IOE S) been us ed t reat choledocholithiasis.The purpose this study was compare clinical outcomes hospital costs LCBDE with IOES. METHODS:Between November 1999 October 2002, choledocholithiasis undergoing LC plus (Group A, n=45) were retrospectively compared those IOES B,...
AIM: Transcystic biliary decompression (TCBD) has been proposed as an alternative to T-tube placement after laparoscopic choledochotomy (LCD).This permits safe primary closure of the and eliminates complications associated with T-tubes.TCBD tube secured by Roeder knots transfixation, removed later than 3 wk surgery.We presented a modified TCBD (mTCBD) method LCD using ureteral catheter Lapro-Clip (David Geck, Danbury, Connecticut, USA), compared it drainage. METHODS: Between October 2002...
Open-label trials suggest that escitalopram (up to 20 mg/d) is an effective treatment for some, but not all posttraumatic stress disorder (PTSD) patients. Higher doses of effectively reduced major depression symptoms in patients who had responded regular doses. The current study examines the efficacy, tolerability, and adherence high-dose PTSD.Forty-five PTSD received 12 weeks gradually increasing reaching 40 mg daily at 4 weeks. Among those, participants antidepressants onset including (n =...
Background and aims: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis can be reduced following endoscopic papillary balloon dilation with the placement of an nasobiliary drainage (ENBD) catheter. The aim this study was to determine whether ENBD reduces risk post-ERCP large together biliary sphincterotomy.Methods: A total 160 patients bile duct stones were randomly assigned (1:1) group or no-ENBD group. primary outcome incidence pancreatitis. secondary...
Disengagement from treatment is common in first episode schizophrenia (FES) and associated with poor outcomes. Our aim was to determine whether hippocampal subfield volumes predict disengagement during maintenance of FES.FES patients were recruited sites Boston, New York, Shanghai, Changsha. After stabilization on antipsychotic medication, participants randomized add-on citalopram or placebo followed for 12 months. Demographic, clinical cognitive factors at baseline compared between...
Abstract Background Previous work has indicated that post-traumatic stress disorder (PTSD) symptoms, measured by the Clinician-Administered PTSD Scale (CAPS) within 60 days of trauma exposure, can reliably produce likelihood estimates chronic among survivors admitted to acute care centers. Administering CAPS is burdensome, requires skilled professionals, and relies on symptoms are not fully expressed upon admission. Predicting from peritraumatic responses, which obtainable admission, yielded...