A5055550922- Virus-based gene therapy research
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Mathematical Biology Tumor Growth
- Bioinformatics and Genomic Networks
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- CAR-T cell therapy research
- Ethnobotanical and Medicinal Plants Studies
- Evolution and Genetic Dynamics
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Artificial Intelligence in Healthcare
- Phytochemistry and Biological Activities
- interferon and immune responses
- thermodynamics and calorimetric analyses
- Imbalanced Data Classification Techniques
- Renal and related cancers
- Immunotherapy and Immune Responses
- Food Science and Nutritional Studies
- Machine Learning in Healthcare
- Greenhouse Technology and Climate Control
- Livestock Management and Performance Improvement
- Agricultural Systems and Practices
University of Pittsburgh
2019-2024
UPMC Hillman Cancer Center
2019-2024
Baylor University
2024
University of Pittsburgh Medical Center
2022-2023
Neurological Surgery
2022-2023
Children's Hospital of Pittsburgh
2022-2023
Madan Mohan Malaviya University of Technology
2022
Louisiana State University Health Sciences Center New Orleans
2021
Deen Dayal Upadhyaya Gorakhpur University
2017
Tata Trusts
2013
Abstract Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight IDH primary GBMs and defined signature (NES) tumor. show that NES significantly associates with activation transcription factors regulate brain development, including MYBL2...
Abstract Multiple studies have associated the transcription factor IRF1 with tumor-suppressive activities. Here, we report an opposite tumor cell–intrinsic function of in promoting growth. IRF1-deficient cells showed reduced growth MC38 and CT26 colon carcinoma B16 melanoma mouse models. This reduction was dependent on host CD8+ T cells. Detailed profiling tumor-infiltrating leukocytes did not show changes various T-cell myeloid cell populations. However, that had infiltrated IRF1-deficieint...
Abstract IFN regulatory factor 1 (IRF1) can promote antitumor immunity. However, we have shown previously that in the tumor cell, IRF1 growth, and IRF1-deficient cells exhibit severely restricted growth several syngeneic mouse models. Here, investigate potential of functionally modulating to reduce progression prolong survival. Using inducible expression, established it is possible regulate expression modulate B16-F10 tumors. Expression IRF2, which a functional antagonist IRF1, downregulated...
A study of ancient literature indicates that diabetes was fairly well known and conceived as an entity in India. Plant-based drugs have been used against various diseases since a long time. The nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. essential values some plants published, but large number them remained unexplored to date. Therefore, there is necessity explore their uses conduct pharmacognostic pharmacological studies ascertain...
Glioblastoma (GBM) is the most common and lethal primary brain tumor with high mortality rates a short median survival rate of about 15 months despite intensive multimodal treatment maximal surgical resection, radiotherapy, chemotherapy. Although immunotherapies have been successful in various cancers, disappointing results from clinical trials for GBM immunotherapy represent our incomplete understanding. The development alternative humanized mouse models fully functional human immune cells...
Abstract Glioblastoma (GBM) is the most common and lethal primary brain tumor. The development of alternative humanized mouse models with fully functional human immune cells will potentially accelerate progress GBM immunotherapy. We successfully generated DRAG (NOD.Rag1KO.IL2RγcKO) model by transplantation DR4+ hematopoietic stem (hHSCs), effectively grafted patient-derived tumorsphere to form xenografted tumors intracranially. engrafted recapitulated pathological features cell composition...
Alcohol is a risk factor for pancreatic cancer. However, the molecular mechanism by which chronic alcohol consumption influences cancer development not well understood. We have recently demonstrated that ethanol exposure of normal ductal epithelial cells (HPNE) induces cellular transformation generating stem (CSCs). Here, we examined whether treatment epithelial-mesenchymal transition in HPNE and promotes KC (Pdx1-Cre, LSL-KrasG12D ) mice. Our data demonstrate SATB2 gene those became highly...
Saxifraga ligulata belongs to family saxifragaceae, is an accepted source of ayurvedic medicine Pashanabheda.This plant has been already recognized for its role in dissolving kidney stone.This review supports all updated information on chemical constituents, pharmacological activities, traditional uses and scientific approach.The entities this have used as Antibacterial, Antiviral, Antipyretic, Antidiabetic, Anti inflammatory, Diuretic, Antiurolithiatic, Antioxidant, Antitussive...
Special AT-rich sequence binding protein-2 (SATB2) is a nuclear matrix protein that binds to attachment regions and involved in chromatin remodeling transcription regulation. In stem cells, it regulates the expression of genes required for maintaining pluripotency self-renewal epithelial–mesenchymal transition (EMT). this study, we examined oncogenic role SATB2 prostate cancer assessed whether overexpression human normal epithelial cells (PrECs) induces properties (CSCs). The results...
<p>Supplementary Figure S3 with legend</p>
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<p>Supplementary Figure S2 with legend</p>
<p>Supplementary Figure S5 with legend</p>
<div>Abstract<p>IFN regulatory factor 1 (IRF1) can promote antitumor immunity. However, we have shown previously that in the tumor cell, IRF1 growth, and IRF1-deficient cells exhibit severely restricted growth several syngeneic mouse models. Here, investigate potential of functionally modulating to reduce progression prolong survival. Using inducible expression, established it is possible regulate expression modulate B16-F10 tumors. Expression IRF2, which a functional antagonist...
<p>Supplementary Figure S5 with legend</p>
<p>Supplementary Figure S1 with legend</p>
<p>Exhausted T cells gating strategy</p>