A5033518970- interferon and immune responses
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glycosylation and Glycoproteins Research
- Antimicrobial Peptides and Activities
- Mosquito-borne diseases and control
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Biosensors and Analytical Detection
- FOXO transcription factor regulation
- Animal Genetics and Reproduction
University of Washington
2016-2025
Alpine Immune Sciences (United States)
2017-2021
Seattle University
2013-2021
Cancer Institute (WIA)
2014
Frederick National Laboratory for Cancer Research
2007-2013
Center for Cancer Research
2008-2011
National Institutes of Health
2009-2011
National Cancer Institute
2007-2011
University of Miyazaki
2004-2010
Kagoshima University
2002-2005
Vascular disrupting agents (VDAs) represent a novel approach to the treatment of cancer, resulting in collapse tumor vasculature and death. 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is VDA currently advanced phase II clinical trials, yet its precise mechanism action unknown despite extensive preclinical investigations. Our data demonstrate that DMXAA specific activator TANK-binding kinase 1 (TBK1)–interferon (IFN) regulatory factor 3 (IRF-3) signaling pathway. primary mouse macrophages...
Many host RNA sensors are positioned in the cytosol to detect viral during infection. However, most positive-strand viruses replicate within a modified organelle co-opted from intracellular membranes of endomembrane system, which shields products cellular innate immune sensors. Targeting system may enhance their ability sense generated by that use these compartments for replication. Here, we reveal an isoform oligoadenylate synthetase 1, OAS1 p46, is prenylated and targeted system. Membrane...
Interleukin (IL)-10 was cloned from the common carp (Cyprinus carpio L.) using IL-10 primers head kidney following stimulation with concanavalin A and lipopolysaccharide. The cDNA consisted of a 1096 bp sequence containing 55 5' untranslated region 498 3' region. An open reading frame 543 encoded putative 180 amino acid protein signal peptide 22 acids. signature motif is conserved in sequence. 2083 genomic found to contain five exons interrupted by four introns. With exception much more...
In teleosts, the genomic organization of immunoglobulin (Ig) heavy (H)-chain locus was thought to follow a typical translocon-type multigene structure; however, recent studies have indicated variation in structure and this might be teleost specific. Isotypes Ig H-chain, namely IgM, IgD, IgZ IgT, been identified. study, we report discovery new class IgH from fugu. This isotype first identified sequence fugu locus. novel gene is composed two constant (C) domains, hinge region, exons encoding...
Synthetic oligonucleotides ( ODN ) expressing C p G motifs mimic the ability of bacterial DNA to trigger innate immune system via TLR 9. Plasmacytoid dendritic cells (p DC s) make a critical contribution ensuing response. This work examines induction antiviral IFN ‐β) and pro‐inflammatory IL ‐6) cytokines by ‐stimulated human s CAL ‐1 cell line. Results show that interferon regulatory factor‐5 IRF ‐5) NF ‐κ B p50 are key co‐regulators ‐β ‐6 expression following 9‐mediated activation s. The...
Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unknown mechanism. Intriguingly, human harbors variant introduces premature stop codon. We performed molecular biochemical characterization IFNλ4 determine its role regulation expression. found exhibits...
Regulatory T cells (Tregs) suppress the activation and subsequent effector functions of CD4 (Teffs). However, molecular mechanisms that enforce Treg-mediated suppression in Teff are unclear. We found Tregs suppressed activation-induced global protein synthesis Teffs prior to cell division. analyzed genome-wide changes transcriptome translatome activated Teffs. show mRNAs encoding for machinery regulated at level translation by Tregs. specifically inhibiting mTORC1-mediated control through...