A5005349469- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- RNA regulation and disease
- Invertebrate Immune Response Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- RNA Research and Splicing
- interferon and immune responses
- Viral Infections and Immunology Research
- NF-κB Signaling Pathways
University of Washington
2022-2025
University of Arizona
2018-2024
Neurons are postmitotic, nonregenerative cells that have evolved fine-tuned immunological responses to maintain life-long cellular integrity, including resistance common programmed cell death pathways such as necroptosis. We previously demonstrated a necroptosis-independent role for the key necroptotic kinase RIPK3 in host defense against neurotropic flavivirus infection. Here, we show activation had distinct outcomes primary cortical neurons when compared with mouse embryonic fibroblasts...
Abstract Neurons are post-mitotic, non-regenerative cells that have evolved fine-tuned immunological responses to maintain life-long cellular integrity; this includes resistance common programmed cell death (PCD) pathways, including apoptosis and necroptosis. We previously demonstrated a necroptosis-independent role for the key necroptotic kinase RIPK3 in host defense against neurotropic flavivirus infection. While work showed neuronal expression is essential chemokine production recruitment...
CD4 + T cells use cell receptor (TCR)–CD3 complexes, and CD4, to respond peptide antigens within MHCII molecules (pMHCII). We report here that, through ~435 million years of evolution in jawed vertebrates, purifying selection has shaped motifs the extracellular, transmembrane, intracellular domains eutherian that enhance pMHCII responses, covary with residues an motif inhibits responses. Importantly, while interactions Src kinase, Lck, are viewed as key our data indicate CD4–Lck derive their...
CD4 + T cell activation is driven by 5-module receptor complexes. The (TCR) the module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 coreceptor module. reciprocally TCR-CD3-pMHCII assemblies on outside a cells Src kinase, LCK, inside. Previously, we reported transmembrane GGXXG cytoplasmic juxtamembrane (C/F)CV+C motifs found in eutherian (placental mammal) have...
CD4 + T cell activation is driven by five-module receptor complexes. The (TCR) the module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 coreceptor module. reciprocally TCR-CD3-pMHCII assemblies on outside a cells Src kinase, LCK, inside. Previously, we reported transmembrane GGXXG cytoplasmic juxtamembrane (C/F)CV+C motifs found in eutherian (placental mammal)...
CD4 + T cell activation is driven by five-module receptor complexes. The (TCR) the module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 coreceptor module. reciprocally TCR-CD3-pMHCII assemblies on outside a cells Src kinase, LCK, inside. Previously, we reported transmembrane GGXXG cytoplasmic juxtamembrane (C/F)CV+C motifs found in eutherian (placental mammal)...
SUMMARY CD4 + T cells use cell receptor (TCR)-CD3 complexes, and CD4, to respond peptide antigens within MHCII molecules (pMHCII). We report here that, through ∼435 million years of evolution in jawed vertebrates, purifying selection has shaped motifs the extracellular, transmembrane, intracellular domains eutherian that both enhance pMHCII responses are coevolving with residues an motif inhibits responses. Importantly, while interactions Src kinase, Lck, classically viewed as key...
CD4 + T cell activation is driven by 5-module receptor complexes. The (TCR) the module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 coreceptor module. reciprocally TCR-CD3-pMHCII assemblies on outside a cells Src kinase, Lck, inside. Previously, we reported transmembrane GGXXG motif cytoplasmic juxtamembrane (C/F)CV+C found in eutherian (placental mammals) have...
Abstract CD4 + T cell activation is driven by 5-module receptor complexes. The (TCR) the module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 coreceptor module. reciprocally TCR-CD3-pMHCII assemblies on outside a cells Src kinase, LCK, inside. Previously, we reported transmembrane GGXXG cytoplasmic juxtamembrane (C/F)CV+C motifs found in eutherian (placental...