A5044306169- Nanoplatforms for cancer theranostics
- Satellite Communication Systems
- Advanced Nanomaterials in Catalysis
- Opportunistic and Delay-Tolerant Networks
- IoT Networks and Protocols
- Nanocluster Synthesis and Applications
- Radioactive contamination and transfer
- Single-cell and spatial transcriptomics
- Spacecraft Design and Technology
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Radioactivity and Radon Measurements
- Space Satellite Systems and Control
- Immune cells in cancer
- GNSS positioning and interference
- Spacecraft Dynamics and Control
- Aerospace Engineering and Control Systems
- Radio Astronomy Observations and Technology
- Interconnection Networks and Systems
- Software-Defined Networks and 5G
- Coastal wetland ecosystem dynamics
- Mathematical Biology Tumor Growth
- Photodynamic Therapy Research Studies
- Cancer Genomics and Diagnostics
Shanghai Jiao Tong University
2020-2025
University of Michigan
2024-2025
Ruijin Hospital
2021-2024
City University of Hong Kong
2024
University of Chinese Academy of Sciences
2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
BGI Group (China)
2024
BGI Research
2024
Beijing Tian Tan Hospital
2024
Abstract Altered metabolism of cancer cells reshapes the unique tumor microenvironment (TME) with glucose addiction and high antioxidant levels, resulting in a strong alliance to promote progression treatment failure. Herein, Pd/Pt/Au tri‐metallic mesoporous nanoparticle coated pH‐responsive tannic acid‐iron ion (Fe III TA) network (PdPtAu@TF) is fabricated, aiming at reinforcing radioimmunotherapy by reprogramming nutrients redox metabolisms. PdPtAu@TF has fine hierarchical structure...
Mild‐temperature photothermal therapy (MPTT) is a promising tumor therapeutic modality because it can avoid the damage of normal tissues near caused by excessive heat. However, its effect severely impaired cells develop heat resistance and self‐repair activating shock response cell autophagy. Herein, tannic acid–iron ion metal organic framework‐coated, chloroquine (CQ)‐loaded mesoporous PdPt nanosystem (TF‐CQ@mPdPt) developed to enhance MPTT simultaneous suppression TF‐CQ@mPdPt exhibits good...
Abstract Mild‐temperature photothermal therapy (mild‐PTT, 42–45 °C) offers a higher level of biosafety. However, its therapeutic effects are compromised by the heat shock response (HSR), cellular self‐defense mechanism, which triggers overexpression proteins (HSPs) with capacity repairing damaged tumor cells. Herein, this work fabricates novel nanoreactor incorporating up‐conversion nanoparticles (UCNPs), chlorin e6 (Ce6), and glucose oxidase (GOx) onto ultrathin black phosphorus nanosheet...
Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin (snATAC-seq), spatial transcriptomics profiles identified distinct populations SHH (sonic hedgehog) Group_3 subgroups, with varying proportions local or Local showed higher...
Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear. We analyze single-nucleus and transcriptomes chromatin accessibility from human MB spanning four subgroups, to identify malignant populations describe evolutionary trajectories. The CNVs patterns niches were analyzed investigate interactions. Three main identified, including progenitor-like, cycling differentiated populations. Gene signatures strongly correlate...
Abstract 7 Be and 210 Pb, two atmospherically delivered radionuclides, have been broadly applied to study the processes including air mass transport, soil erosion, particle cycling in aqueous systems. These studies require temporal variations of their depositional fluxes. In present work, monthly atmospheric bulk fluxes Pb were measured over 8 years (December 2005 December 2013) at Shanghai, China. The varied from 17.9 421 Bq m −2 month −1 6.8 82.1 , respectively. volume‐weighted activities...
The bis-(diethyldithiocarbamate)-copper (CuET), the disulfiram (DSF)-Cu complex, has exhibited noteworthy anti-tumor property. However, its efficacy is compromised due to inadequate oxidative conditions and limitation of bioavailable copper. Because CuET can inactivate valosin-containing protein (VCP), a bioinformatic pan-cancer analysis VCP first conducted in this study identify as promising anticancer drug for diverse cancer types. Then, based on action mechanism, nanocomposite copper...
Recently, non-terrestrial-satellite-networks (NTSN) have attracted more attention due to excellent performance. NTSN specifically refers a mega satellite constellation network. Global coverage, low latency and high data rate make global interconnection possible. However, the lack of on-board energy degrades efficiency network system. To solve those pressing problems, an sensitive congestion balance (ESCB) routing scheme is proposed in this paper. compensate for limited satellites, tubular...
The acidic microenvironment is one of the remarkable features tumor and also a reliable target for theranostics. Ultrasmall gold nanoclusters (AuNCs) have good in vivo behaviors, such as non-retention liver spleen, renal clearance, high permeability, held great potential developing novel radiopharmaceuticals. Herein, we developed pH-sensitive ultrasmall by introducing quaternary ammonium group (TMA) or tertiary amine motifs (C6A) onto glutathione-coated AuNCs (TMA/GSH@AuNCs, C6A-GSH@AuNCs)....
In beyond 5G (B5G) non-terrestrial network (NTN) systems, satellite technologies play an important role. Especially for data collection systems (DCS), low-earth orbit satellites have many advantages. Such as global coverage, low latency, and high efficiency. As a miniaturization technology, CubeSat has attracted extensive attention from large number of scholars. Satellite constellations can coordinate distributed tasks. This paper proposes B5G NTN-based system. A constellation achieves...
Spacecraft formation flying (SFF) in highly elliptical orbit (HEO) has attracted much attention since many applications space explore, while precise guidance navigation and control (GNC) technology, especially ranging, conducted the basis of success for such SFF missions. In this paper, we introduced a novel K band microwave ranging (MWR) equipment that aimed on-orbit verification submillimeter level technology future HEO The technique is synchronous dual one-way (DOWR) phase accumulation...
Recently, Non-Terrestrial Satellite Networks (NTSTs) have gained more and attentions due to global coverage, low latency, high-speed communications. The routing scheme is one of the primary challenges for NTSNs, mega scale an NTSN constellation dynamic topology feature. To solve many pressing problems, a Compass time-space Model-based Virtual IP (CMVIP) proposed in this paper. In order compensate discontinuities existing models, compass-shaped model proposed. It can be adapted with...
Abstract Background Medulloblastoma (MB) is one of the most common malignant brain tumors that mainly affect children. Various approaches have been used to model MB facilitate investigating tumorigenesis. This study aims compare recapitulation between subcutaneous patient‐derived xenograft (sPDX), intracranial (iPDX), and genetically engineered mouse models (GEMM) at single‐cell level. Methods We obtained primary human sonic hedgehog (SHH) group 3 (G3) samples from six patients. For each...
Abstract Purpose: The tumor microenvironment (TME) is a pivotal factor in the progression and treatment response of cancers, including medulloblastoma (MB), most common malignant brain children. This study investigates TME-specific gene signatures to create prognostic model for MB patient outcomes. Methods: We sequenced 240 samples at Beijing Tiantan Hospital with RNASeq analyzed TME components. Through co-expression network analysis regression models, we identified an eight-gene signature...
Gold nanoclusters (AuNCs) have great potential to enhance tumor radiotherapy. However, their accumulation efficiency is relatively low due ultrasmall size. In this study, an acid-responsive targeting strategy proposed by introducing l-cystine onto glutathione-coated AuNCs (l-Cys/GSH@AuNCs). l-Cys/GSH@AuNCs are able swiftly respond acid conditions assembly into large clusters and aggregate in lysosomes upon internalization cells, leading increased cancer cells. Moreover, metal radioisotope...
Abstract As the novel research of space technologies, non-terrestrial-network (NTN) is one most important technologies. Mega satellite constellation baseline NTN Unfortunately, as density deployment, risk collisions between satellites also increases significantly. Therefore, sensing technology an solution to avoid within constellation. In this article, a system for proposed. It contains multiple subsystems working together ensure measurement accuracy. An accurate laser based on frequency...