A5103127344- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Kawasaki Disease and Coronary Complications
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Heavy Metal Exposure and Toxicity
- Adenosine and Purinergic Signaling
- Virus-based gene therapy research
- Microbial infections and disease research
- Cancer, Hypoxia, and Metabolism
- Ziziphus Jujuba Studies and Applications
- Pneumonia and Respiratory Infections
- Listeria monocytogenes in Food Safety
- Atherosclerosis and Cardiovascular Diseases
- Ginseng Biological Effects and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inflammasome and immune disorders
- Spondyloarthritis Studies and Treatments
- Genomics, phytochemicals, and oxidative stress
- Salmonella and Campylobacter epidemiology
- Celiac Disease Research and Management
- Amino Acid Enzymes and Metabolism
- Cancer and biochemical research
Fujian Medical University
2024
Xiamen University
2024
Children's Hospital of Zhejiang University
2006-2023
Yangzhou University
2020
Bethune International Peace Hospital
2019
Zhejiang University
2014-2015
Tianjin University of Commerce
2011
As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study to learn more about the clinical features evaluate role of cytokines in KDSS.We collected laboratory data retrospectively for all patients with KDSS(KDSS, n = 27)who were hospitalized at our hospital from Jan 2014 Oct 2017. For patient KDSS, we randomly identified 43 KD as control subjects (KD, 43). Clinical features,...
Summary Background and objective The mechanisms of Mycoplasma pneumoniae induced lung inflammation are not clearly understood yet. This study investigated whether activated T cells in the airway contributed to pulmonary patients with severe pneumonia (MPP). Methods BALF were collected all 45 MPP (MPP, n = 45), including mild (Mild, 20) (Severe, 25) group. 20 25 cases at recovery stage (Rec‐severe, again. control group consisted foreign body aspiration (Con., 20). CD3+ cells, CD69+, HLA‐DR+,...
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in (ADA2), has not been systemically investigated Chinese population yet. We aim to further characterize DADA2 cases China.A retrospective analysis patients with identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were...
This study aims to explore and evaluate the effects of Semen Ziziphi Spinosae extracts on serum levels interleukin (IL)-6, IFN-γ, IL-1β, TNF-α, IL-10 IL-4 in mice, regulative effect cytokine system. Using an ELISA assay, IL-6, were examined mice after intraperitoneal injection (i.p.) with extracts. The results showed that IL-6 IL-1β significantly increased compared control groups (p < 0.01), while level tumour necrosis factor-α (TNF-α) was decreased 0.01). possesses certain modulation...
The hyper-IgM syndromes (HIGMs) are a group of primary immune deficiency diseases characterized by normal or elevated serum level IgM and low absent levels IgG, IgA IgE. Here, we report case X-linked HIGM with new CD40L gene mutation presenting eosinophilia. patient experienced recurrent pneumonia acute respiratory distress syndrome (ARDS) from 4 months age. Immunological evaluation revealed IgM, significantly IgG IgA. Genetic analysis the splice in exon 5 at nucleotide position 410...
Background: Monoclonal antibody (mAb)-based targeted therapy is one of the most promising strategies to cure cancers. MAb ZCH-2B8a (2B8a) was a novel generated in our laboratory, which presented potential be therapeutic agent for hematologic malignancies.Methods: We investigated reactivity profile 2B8a mAb, identified targeting antigen by proteomic and genetic approaches evaluated its exert tumor cell killing.Results: strictly expressed on lymph tissues hematopoietic cells (mainly...
Listeria monocytogenes ( Lm ) is a foodborne zoonotic pathogen that causes listeriosis with mortality rate of 20–30%. Serovar 4b and 1/2b isolates account for most outbreaks, however, no vaccine available either prophylactic or therapeutic use. Here, we developed triple-virulence-genes deletion strain, evaluated its safety, immunogenicity, cross-protective efficiency. The virulence NTSNΔ actA / plcB orfX was reduced 794-folds compared the parental strain. Additionally, it completely...
Radiotherapy plus temozolomide followed by adjuvant was the standard treatment for high-grade gliomas. This study aimed to explore effectiveness and safety of addition apatinib in patients with gliomas after surgery. In this retrospective cohort study, glioma [World Health Organization (WHO) grade III or IV] treated concurrent chemoradiotherapy (cCRT) surgery from October 2017 February 2021 were reviewed. High-grade used cCRT alone same period reviewed as control group. Progression-free...
To evaluate the efficacy and safety of humanized anti-IL-6 receptor monoclonal antibody (tocilizumab) in treatment systemic juvenile idiopathic arthritis (sJIA).Thirteen sJIA patients admitted between December 2015 November 2016 received tocilizumab were enrolled study. The complete blood count (CBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6) ferritin levels measured; American College Rheumatology Pediatric(ACR Pedi)30/50/70/90 scores assessed; use...
To analyze the clinical manifestation and genetic mutation of a child with tyrosinemia type I but without elevated succinylacetone.Clinical data patient was collected. Tandem mass spectrometry gas chromatography were used to blood amino acid urine organic component proband. DNA extracted from his parents for analysis.The proband acute type, features including hepatomegaly, jaundice, anemia tendency bleeding. Serum levels Tyrosine, Methionine Phenylalanine 397.12 μmol/L, 896.16 μmol/L 292.52...
Background: Macrophage activation syndrome (MAS) is a severe, potentially life-threatening complication of systemic juvenile idiopathic arthritis (SJIA). However, early recognition MAS remains challenging. Because it clinically heterogeneous, hemophagocytosis often not detected, and histopathological features lack the specificity associated with hemophagocytic syndromes. In addition, difficult to distinguish from SJIA or sepsis-like Objectives: To identify clinical laboratory characteristics...
To investigate the serum levels of Th1/Th2 cytokines in children with non-systemic juvenile onset idiopathic arthritis (non-SOJIA).Clinical data 41 non-SOJIA, including 11 cases polyarthritis, 10 oligoarthritis and 20 enthesitis related JIA (ERA), admitted Children's Hospital Zhejiang University School Medicine during November 2012 May 2015 were retrospectively analyzed. Serum IL-2, IL-4, IL-6, IL-10, TNF-α IFN-γ measured by flow cytometry patients compared those SOJIA (SOJIA group, n=85)...