A5100751013- Renal cell carcinoma treatment
- Kidney Stones and Urolithiasis Treatments
- Inflammatory Myopathies and Dermatomyositis
- Prostate Cancer Treatment and Research
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Nematode management and characterization studies
- Urinary Tract Infections Management
- Mesenchymal stem cell research
- Renal and Vascular Pathologies
- Muscle Physiology and Disorders
- Oral Health Pathology and Treatment
- Prostate Cancer Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Soil Carbon and Nitrogen Dynamics
- Urological Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Plant-based Medicinal Research
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Ureteral procedures and complications
- T-cell and B-cell Immunology
Affiliated Hospital of Qingdao University
2014-2025
Qingdao University
2014-2025
Shandong First Medical University
2024-2025
Shandong Eye Hospital
2025
East China University of Science and Technology
2025
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Capital Institute of Pediatrics
2013-2024
Children's Hospital of Zhejiang University
2024
Robert Bosch (Germany)
2024
Objective: To explore the clinical effectiveness of glucocorticoids combined with amniotic membrane transplantation in treatment severe marginal ulcerative keratitis. Methods: A retrospective case series study was conducted. Data from 10 patients (10 eyes) keratitis who received glucocorticoid administration at Eye Hospital Shandong First Medical University October 2017 to May 2022 were collected. There 6 males and 4 females an average age 61.3 years. All underwent corneal scraping,...
Methods for catalytically constructing of N–N axially chiral scaffolds have garnered significant attention since such compounds are widely present in natural products, bioactive molecules, and organic materials. Herein, we report a highly diastereoselective enantioselective organocatalyzed [4 + 1] annulation method synthesizing diverse valuable isoindolinones that possessing axial central chiralities. This methodology uses phosphoric acid as bifunctional catalyst to promote cascade sequence...
Background CD19+CD24hiCD38hi transitional immature B-lymphocytes have been demonstrated to play an important role in regulating the alloimmune response transplant recipients. Here, we analyzed effect of calcineurin inhibition on these peripherally circulating regulatory B-cells (Breg) renal recipients receiving cyclosporine A (CsA) or tacrolimus. Methods PBMCs from healthy subjects (HS) (n = 16) and 46) were isolated. Flow cytometry was performed for CD19, CD24, CD38 IL-10 either after...
Abstract Objective To evaluate the use of Janus kinase inhibitor (JAKi) in treating JDM and develop cytokine biomarkers active disease. Methods This study involved a retrospective cohort that evaluated JAKi 101 patients as well cross-sectional cytokines 128 30 controls between November 2017 December 2021 Affiliated Children’s Hospital Capital Institute Pediatrics (China). Results During median follow-up period 19 months, 65.5% had improved rashes, CAT-BM scores decreased. Overall, 39.6%...
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in (ADA2), has not been systemically investigated Chinese population yet. We aim to further characterize DADA2 cases China.A retrospective analysis patients with identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were...
Chronic kidney disease (CKD) is a common postoperative complication in patients who undergo radical nephrectomy for renal tumours. However, the factors influencing long-term function require further investigation.
Abstract Objective The objective of this study was to develop and evaluate the performance machine learning models for predicting possibility systemic inflammatory response syndrome (SIRS) following percutaneous nephrolithotomy (PCNL). Methods We retrospectively reviewed clinical data 337 patients who received PCNL between May 2020 June 2022. In our study, 80% were used as training set, remaining testing set. Separate prediction based on six algorithms created using predictive each model...
Antibody-mediated lymphocyte depletion is frequently used as induction therapy in sensitized transplant patients. Although T cells with an effector/memory phenotype remain detectable after lymphoablative therapies human recipients, the role of preexisting donor-reactive memory reconstitution cell repertoire and alloimmune responses following lymphoablation poorly understood. We show a mouse cardiac transplantation model that antidonor immune treatment rabbit antimouse thymocyte globulin...
Juvenile dermatomyositis (JDM) is a rare and sometimes fatal disease in children. The anti-NXP2 antibody one of the most common antibodies muscle ischaemia associated with NXP2 autoantibodies was severe subtype JDM. Further information needed regarding clinical characteristics factors poor prognosis. But there are no reports about high risk factor For first time, we introduced predictors antibody-associated juvenile Chinese children.Twenty-six patients antibody-related JDM from 85 were...
Abstract The effect of Cu and Zn on soil nematode communities at the depth 0–20 cm was investigated along a pollution gradient with increasing distance from copper smelter in Northeast China. results showed that abundance total nematodes significantly increased smelter, taxon richness also exhibited an trend. Twenty genera were observed our study, Paratylenchus dominant genus all sampling sites. numbers nematodes, bacterivores, plant parasites, omnivores-predators values NCR (Nematode...
Most complex renal stones are managed primarily with percutaneous nephrolithotomy (PCNL). However, PCNL is still a great challenge for surgeons because of poor comprehension on adjacent structures. Novel techniques required to assist in planning and navigation.To apply evaluate the Hisense computer-assisted surgery (CAS) system PCNL.A total 60 patients were included. Thirty CAS group had three-dimensional (3D) virtual models constructed system. The model assisted navigating control planned...
Abstract Background The coronavirus disease 2019 outbreak has hit Beijing since mid-Nov, 2022, with soaring growth of severe acute respiratory syndrome 2 (SARS-CoV-2) among children. Therefore, it is vital to determine the clinical manifestations epidemic SARS-CoV-2 strains in paediatric patients. Methods In this study, nucleic acid tests (NATs) for were performed outpatients symptoms tract infection during 18 Nov–6 Dec, 2022. Half positive randomly selected screen other pathogens, whereas...
Transplantation of mesenchymal stem cells (MSCs) is promising for treatment acute kidney injury (AKI), but their therapeutic effects are often limited under normal conditions. In this study, we prepared the co-gels decellularized vascular matrix and collagen, investigated whether increase potentials MSCs on AKI. vitro studies indicated that enhanced paracrine MSCs, significantly reduced apoptosis oxidative environments. When were co-transplanted with into model rats ischemia-reperfusion...