A5075621620- Liver Disease Diagnosis and Treatment
- Vasculitis and related conditions
- Gut microbiota and health
- Renal Diseases and Glomerulopathies
- Drug-Induced Hepatotoxicity and Protection
- Chronic Kidney Disease and Diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Cell Adhesion Molecules Research
- Genetic Neurodegenerative Diseases
- Inflammasome and immune disorders
- Blood disorders and treatments
- Complement system in diseases
- Erythrocyte Function and Pathophysiology
- Inflammatory Myopathies and Dermatomyositis
- Metabolomics and Mass Spectrometry Studies
- Flavonoids in Medical Research
- Infant Nutrition and Health
- Pharmacological Effects of Natural Compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Medicinal Plant Pharmacodynamics Research
- Caveolin-1 and cellular processes
- Orthopedic Infections and Treatments
Baotou Medical College
2020-2025
Qingdao University
2018-2025
Affiliated Hospital of Qingdao University
2018-2025
Southern Medical University
2025
Shenzhen Maternity and Child Healthcare Hospital
2025
Weatherford College
2023
Inner Mongolia University of Science and Technology
2022
Anhui University of Traditional Chinese Medicine
2021-2022
Heilongjiang University of Chinese Medicine
2017-2018
Sun Yat-sen University
2010
The recent cloning and characterization of the human histamine H(3) receptor cDNA marked a significant step toward greater understanding role this in central nervous system. We now report rat demonstrate distinct pharmacological species differences. clone encodes putative 445-amino acid protein with 93% identity to receptor. Northern blot analysis revealed major single entity 2.7-kb length expressed only brain. Transfection into SK-N-MC cells conferred an ability inhibit forskolin-stimulated...
Reversibility of hepatic fibrosis is an intrinsic response to chronic injury, and with on-going damage, can progress its end-stage consequence, cirrhosis. Non-invasive reliable biomarkers for early detection liver are needed. Based on the CCl
The transmission of certain bacteria from the mother's gut to infant's via breast milk (BM) is critical for offspring's immune system development. Dysbiosis BM microbiota can be caused by a variety reasons, which influenced probiotics delivered enteromammary route. goal this study was investigate that transmitted mother intestine during various lactation periods in 19 mother-child dyads. Bacterial most common colostrum phase when with amplicon sequence variants (ASVs) enter newborn and...
Anzi Tiaochong Fang (ATF) is a traditional Chinese medicine (TCM) Fangji widely used to treat antiphospholipid syndrome-related recurrent pregnancy loss (APS-RPL). This study aimed identify the quality markers and elucidate mechanisms of ATF in treating APS-RPL. Chemical, network pharmacology, vitro verification were employed ATF. HPLC-MS/MS was quantify compounds. APS-RPL targets identified using databases such as HERB, similarity ensemble approach, PharmMapper, Swiss Target Prediction,...
ABSTRACT Pulmonary fibrosis (PF) is a chronic progressive disease marked by alveolar epithelial cell damage. Saorilao‐4 decoction (SRL), traditional Mongolian prescription, has demonstrated therapeutic effects on PF, though its mechanism of action remains elusive. This study used bleomycin‐induced rat model to evaluate SRL's measuring inflammatory factors, assessing fibrosis‐related indices, and performing histopathological lung examinations. Serum metabolite levels in the experimental...
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in (ADA2), has not been systemically investigated Chinese population yet. We aim to further characterize DADA2 cases China.A retrospective analysis patients with identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were...
The development of liver fibrosis is a result chronic injuries may progress to cirrhosis and cancer. In recent years, has become major global problem, the incidence rate mortality are increasing year by year. However, there currently no approved treatments. Research on anti-liver-fibrosis drugs top priority. Dietary polyphenols, such as plant secondary metabolites, have remarkable abilities reduce lipid metabolism, insulin resistance inflammation, attracting more attention potential for...
Baicalin, a major flavonoid extracted from Scutellaria baicalensis Georgi (Lamiaceae), has been shown to exert therapeutic effects on pulmonary fibrosis (PF).To use serum metabolomics combined with biochemical and histopathological analyses clarify anti-PF mechanisms of baicalin metabolic pathways the levels potential biomarkers.Forty male Sprague-Dawley rats were randomly divided into control, PF model, prednisolone acetate-treated (4.2 mg/kg/day) baicalin-treated (25 100 groups. A rat...
Limosilactobacillus reuteri FN041 is a potential probiotic bacterium isolated from breast milk in traditional farming and pastoral areas of China. The purpose this study was to investigate the optimal intervention mode mechanism prevent atopic dermatitis (AD) mice. In I, supplemented dams during late trimester lactation pups after weaning; II, were weaned. AD induced with MC903 plus ovalbumin on ear weaning. effect I preventing significantly better than that II. Compared model group,...
Gut microbiota transmission from mother to offspring is critical infant gut and immune development. Mother's intestine breast milk are rich in secretory immunoglobulin A (sIgA), which can coat a specific bacterial spectrum may be related colonization. Here we analyzed the sIgA-coated bacteria of maternal fecal samples 19 dyads by 16S rRNA amplicon sequencing. For microbiota, both phylogenetic diversity Shannon index show lower trend than those (P < 0.05). beta diversity, all three were...
To evaluate the effects of Qingwen Gupi decoction (QGT) in a rat model bleomycin-induced pulmonary fibrosis (PF), and explore underlying mechanisms by integrating UPLC-Q-TOF/MS metabolomics 16S rDNA sequencing gut microbiota.The animals were randomly divided into control, PF model, pirfenidone-treated, low-, medium-, high-dose QGT groups. The lung tissues examined expression TGF-β, SMAD-3, SMAD-7 mRNAs analyzed. Metabolomic profiles analyzed UPLC-QTOF/MS, intestinal flora prokaryotic 16...
Gushuling (GSL), a well-known hospital preparation composed of traditional Chinese medicine (TCM), has been widely used in the clinical treatment osteoporosis (OP) for decades due to its remarkable therapeutic effect. However, chemical constituents GSL are still unclear so far, which limits in-depth study pharmacodynamic material basis and further restricts application. In this study, we developed strategy qualitative analysis vitro vivo. Based on results ultra-performance liquid...
To use network pharmacology and bioinformatics technology to reveal the mechanism of persicae semen-carthami flos drug pair in treatment renal fibrosis (RF). Compounds traditional Chinese medicine were obtained through Herb database. Appropriate compounds corresponding targets screened out based on 5 rules Lipinski pharmacokinetics. Screening suitable disease miRNAs by microarray chips GEO Find differentially expressed genes analyzing miRNAs. Protein-protein interaction analysis enrichment...
Renal fibrosis (RF) is a pathological process of progression from chronic kidney disease to end-stage renal disease. Amygdalus mongolica traditional Chinese medicine, and our previous studies demonstrated that the n-butanol extract (BUT) amygdalin (AMY) its seeds can prevent RF. However, underlying mechanism remains unclear. The present study investigated exact protective effect A. on A rat model was induced with unilateral ureteral obstruction. Biochemical indicators were measured combined...
Renal fibrosis (RF) precedes all kidney diseases, and eventually progresses to end-stage renal failure. It is one of the main pathological manifestations chronic disease (CKD), which seriously affects patients' quality life. The oil from seeds Amygdalus mongolica has been shown prevent RF in rats, although mechanism action still unclear. aim this study was elucidate mechanisms underlying reno-protective effect A. a rat model using metabolomics transcriptomics. Here, induced by unilateral...
Urinary metabolomics combined with histological progression were utilized to evaluate the therapeutic effect of Scutellariae Radix decoction and baicalin on hepatic fibrosis (HF) explore their mechanisms, intervention targets metabolic pathways. HF rat model was established through subcutaneous injection CCl₄ for 8 weeks. Meanwhile, different doses administered. Histomorphology liver tissue observed scored by HE Masson. metabonomic analysis based UPLC-Q-TOF-MS made changes urinary potential...
Background: The aim of this study was to report the clinical features and mutations in a patient with autosomal-inherited Alport syndrome (AS). Methods: We examined data, mutation analysis results, family tree AS, who had nephrotic as her first manifestation. Results: proband girl 11 months presented nephritic syndromes including gross hematuria but normal renal function. Her treatment course complicated by steroid resistance poor response cyclosporine A cyclophosphamide pulse therapy. Renal...
Background: Immunoglobulin A vasculitis (IgAV) is a kind of systemic mediated by IgA immune complexes (IgA-ICs). Soluble CD89-IgA complex (sCD89-IgA) as type IgA-IC associated with renal involvement in IgAV, the ability blood sCD89-IgA biomarker to predict or multi-organ children IgAV not evident, and this study mainly focused on this.Methods: The clinical characteristics samples 57 pediatric patients were collected. ELISA was used detect plasma IgA-ICs levels. Serum levels detected...
<title>Abstract</title> <bold>Background: </bold>Anti-synthetase syndrome (ASS) is a rare autoimmune myopathy and forms part of the idiopathic inflammatory myopathies (IIMs). A distinctive feature ASS presence anti-aminoacyl tRNA synthase (ARS) antibodies, which target synthetases, leading to inflammation in muscles, lungs, other tissues. <bold>Case presentation: </bold>A case 12-year-old Chinese girl with recurrent fever, myalgia, Gottron's papules reported. Serum creatine kinase was...