A5101812610- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Galectins and Cancer Biology
- Traditional Chinese Medicine Studies
- Cytokine Signaling Pathways and Interactions
- Kawasaki Disease and Coronary Complications
- Cell Adhesion Molecules Research
- Bauxite Residue and Utilization
- Inflammation biomarkers and pathways
- Phytochemistry and biological activity of medicinal plants
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Concrete Corrosion and Durability
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Pharmacological Effects and Toxicity Studies
- Histone Deacetylase Inhibitors Research
- Corneal surgery and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Whipple's Disease and Interleukins
- Renal and Vascular Pathologies
- GDF15 and Related Biomarkers
Wuhan Children's Hospital
2012-2025
Huazhong University of Science and Technology
2010-2025
Union Hospital
2025
Union Hospital
2010-2024
Hunan Normal University
2024
Changsha Normal University
2024
Children's Hospital of Fudan University
2022
Jining Medical University
2021
Stomatology Hospital
2020
TEDA International Cardiovascular Hospital
2009
Abstract Background Treating pediatric acute myeloid leukemia (AML) with NUP98 rearrangement (NUP98-R) is challenging. Standard chemotherapy results in low remission rates. This study aimed to evaluate different induction regimens and explore alternative therapies improve outcomes. Methods retrospective included 111 patients AML treated at our institution from March 2012 2023. Patients were classified into two groups: NUP98-R-positive ( n = 10) NUP98-R-negative 101). We compared their...
Expression of mRNA for eight cytokines was analyzed in an vitro response-proliferation and Ig-secretion--of normal human B lymphocytes. This made possible by the use murine thymoma cells as helper conjunction with T cell supernatant, design DNA sequence-specific primers RT-polymerase chain reaction. mRNAs interleukin (IL)2 IL-4, but also IL-1 alpha beta remained undetectable during whole culture period highly purified prepared a three-step purification protocol. However, tumor necrosis...
Summary Atherosclerosis is an autoimmune inflammatory disease involving both innate and adaptive immune mechanisms. Immune tolerance induction may have therapeutic potential for the suppression of atherosclerosis. Current interest directed towards mucosal induction, especially nasal tolerance. Previous studies shown that heat shock protein 60 (HSP60) recognized as important autoantigen in atherosclerosis, or oral HSP60 can induce ameliorate atherosclerosis by inducing several subsets...
Recently, several studies suggest that galectin-9 (Gal-9) might play a pivotal role in the pathogenesis of autoimmune diseases. However, exact Gal-9 atherosclerosis remains to be elucidated.Serum Gal-9, high-sensitivity C-reactive protein (hs-CRP), interferon- (IFN-) γ, interleukin- (IL-) 4, IL-17, and transforming growth factor- (TGF-) β1 were measured. The effect on peripheral blood mononuclear cells (PBMC) was investigated patients with normal coronary artery (NCA).The lowest level found...
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in (ADA2), has not been systemically investigated Chinese population yet. We aim to further characterize DADA2 cases China.A retrospective analysis patients with identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were...
<h3>Objective</h3> The pathogenesis of dilated cardiomyopathy (DCM) is closely connected with dysfunction the autoimmune system, and CD4<sup>+</sup>CD25<sup>high</sup>CD127<sup>low/−</sup> regulatory T (Treg) cells have a vital role in maintaining self-tolerance. In this study, we compared frequency function Treg between DCM patients normal controls. <h3>Methods Results</h3> frequencies CD4<sup>+</sup>CD25<sup>+</sup> were statistically decreased controls (p<0.05) by flow cytometry,...
Introduction. Numerous studies suggest that total cholesterol content of erythrocyte membranes (CEM) might play a critical role in atherosclerotic plaque progression and instability. However, the exact CEM atherosclerosis remains obscure. Our study was designed to investigate association between severity coronary artery disease (CAD), assess effect rosuvastatin on levels. Methods. levels were assessed 136 participants, including acute syndrome (ACS) (non-ST-segment elevation ACS (NSTEACS)...
Kawasaki disease (KD), an acute self-limiting vasculitis, is the main cause of acquired heart disease. Timely diagnosis and treatment can mitigate occurrence complications improve patient prognosis. Facial nerve paralysis (FNP) ptosis are rare KD rarely reported, but FNP considered a high risk factor for coronary aneurysms. If giant artery aneurysms formed, clinicians should be vigilant when diagnosing formation systemic (SAAs).
Abstract Interference of alternative current (AC) on corrosion X65 steel was investigated in soil. It observed that the unfavorable effect interfering AC able to be effectively inhibited by increasing direct density cathodic protection (CP) system. A clear correlation established between CP and tolerable density. This led a new criterion for assuring effectiveness buried pipelines being interfered with AC. Field experimental results pipeline running below 500 kV transmission line showed...
Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, driven immune cells and cytokines. Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties diseases. However, precise mechanisms of IL-27, especially atherosclerosis remains unknown. In our research, we examined influence administration IL-27 an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both initiation progression atherosclerosis. groups (both progression) receiving recombinant...
Introduction This study aims to analyze the clinical features of Kawasaki disease (KD) shock syndrome (KDSS) and explore its early predictors. Methods A retrospective case–control was used KD cases from February 2016 October 2023 in our hospital. total 28 children with KDSS 307 who did not develop were included according matching factors. Baseline information, manifestations, laboratory indicators compared between two groups. Indicators differences analyzed based on univariate analysis;...
Neutrophil extracellular traps (NETs) are important factors in initiating and perpetuating inflammation. However, the role of NETs different subtypes juvenile idiopathic arthritis (JIA) has been rarely studied. Therefore, we aimed to explore ability JIA-derived neutrophils release effect TNF-α (tumor necrosis factor-alpha) inhibitors on NET formation both
Abstract Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function mutations in ADA2, characterized systemic inflammation, vasculitis, immunodeficiency, and/or hematologic abnormalities. Methods: A retrospective analysis patients with DADA2 diagnosed whole exome sequencing at 17 rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype and treatment responses...
Objective To investigate the timing of traumatic cataract surgery.Methods 37 cases (37 eyes) caused by corneal penetrating injury were retrospectively analyzed.They underwent surgery phacoemulsification or extracapsular extraction combined with posterior intraocular lens implantation at different time during 1 d to l m after injury.Primary secondary IOL was done.Results After 3 months follow-up postoperatively,the visual acuity between no light perception 1.0.It in one eye (2.7％),hand...
Objective To evaluate the postoperative prognosis of modification diet in renal disease formula (MDRD) coronary artery bypass graft surgery (CABG) hospital or 4 years after hospitalization. Methods Two hundred and seventy-two CABG patients were divided into 3 groups according to levels estimated glomerular filtration rate (eGFR) including 35 cases eGFR < 60 ml/min group, 119 ≤ 90 mL/min group 118 ≥90 group. The prognostic factors analyzed by COX proportional hazards models. Kaplan-Meier...