A5101644539- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Cardiac Ischemia and Reperfusion
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Psoriasis: Treatment and Pathogenesis
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Tyrosine Phosphatases
- Viral Infections and Immunology Research
- Inflammasome and immune disorders
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Dermatology and Skin Diseases
- Sperm and Testicular Function
- Protease and Inhibitor Mechanisms
- Acute Myocardial Infarction Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- PARP inhibition in cancer therapy
- Antioxidant Activity and Oxidative Stress
Union Hospital
2012-2024
Huazhong University of Science and Technology
2012-2024
Foshan Maternity and Child Health Care Hospital
2023
Southern Medical University
2023
Union Hospital
2014-2022
Wuhan Union Hospital
2019
Innate immune and inflammatory responses are involved in myocardial ischaemia/reperfusion (I/R) injury. Interleukin (IL)-37 is a newly identified member of the IL-1 family, functions as fundamental inhibitor innate immunity inflammation. However, its role I/R injury remains unknown. or sham operations were performed on male C57BL/6J mice. mice received an injection recombinant human IL-37 vehicle, immediately before reperfusion. Compared with vehicle treatment, treated showed obvious...
Our previous study indicated that interleukin (IL)-37 is involved in atherosclerosis. In the present study, Anterior tibial arteries were collected from diabetes patients and controls. A histopathological analysis showed IL-37 was over-expressed human atherosclerotic plaques. Many types of cells including macrophages, vascular smooth muscle (VSMCs), endothelial T lymphocyte expressed ApoE-/- mice divided into a control group recombinant IL-37-treated group. The treatment resulted significant...
Background Excessive immune‐mediated inflammatory reactions play a deleterious role in postinfarction ventricular remodeling. Interleukin‐37 ( IL ‐37) emerges as an inhibitor of both innate and adaptive immunity. However, the exact ‐37 plus troponin I (TnI)–treated dendritic cells DC s) remodeling after myocardial infarction MI ) remains elusive. Methods Results was induced by permanent ligation left anterior descending artery. Our results showed that treatment with recombinant human...
Recent studies suggest that IL-38 is associated with autoimmune diseases. Furthermore, expressed in human atheromatous plaque. However, the plasma levels of patients ST-segment elevation myocardial infarction (STEMI) have not yet to be investigated.On admission, at 24 h, 48 and 7 days, IL-38, C-reactive protein (CRP), cardiac troponin I (cTNI), N-terminal prohormone brain natriuretic peptide (NT-proBNP) were measured gene peripheral blood mononuclear cells (PBMCs) was detected STEMI...
Aims . miR‐208a is associated with adverse outcomes in several cardiac pathologies known to have increased apoptosis, including myocardial infarction (MI). We investigated if has proapoptotic effects on ischemic cardiomyocytes and its silencing therapeutic benefits MI. Methods Results The effect of apoptosis during ischemia was studied cultured neonatal mice myocytes transfected agomir or antagomir. Differential gene expression assessed using microarrays. MI induced male C57BL/6 randomly...
Background and Purpose Numerous in vitro studies have suggested that digoxin suppresses inflammation alters lipid metabolism. However, the effect of dioxin on atherosclerosis is poorly understood. The present study was conducted to determine whether affects development a murine model atherosclerotic disease. Experimental Approach Apolipoprotein E‐deficient mice maintained Western‐type diet were administered PBS (control), low‐dose (1 mg·kg −1 · day ) or high‐dose (2 via i.p. injection for 12...
Abstract Excessive immune‐mediated inflammatory reaction plays a deleterious role in ventricular remodelling after myocardial infarction (MI). Interleukin (IL)‐38 is newly characterized cytokine of the IL‐1 family and has been reported to exert protective effect some autoimmune diseases. However, its cardiac post‐MI remains unknown. In this study, we found that expression IL‐38 was increased infarcted heart MI induced C57BL/6 mice by permanent ligation left anterior descending artery....
Recently, several studies suggest that galectin-9 (Gal-9) might play a pivotal role in the pathogenesis of autoimmune diseases. However, exact Gal-9 atherosclerosis remains to be elucidated.Serum Gal-9, high-sensitivity C-reactive protein (hs-CRP), interferon- (IFN-) γ, interleukin- (IL-) 4, IL-17, and transforming growth factor- (TGF-) β1 were measured. The effect on peripheral blood mononuclear cells (PBMC) was investigated patients with normal coronary artery (NCA).The lowest level found...
Thymic stromal lymphopoietin (TSLP) is a cytokine with multiple effects on the body. For one thing, TSLP induces Th2 immunoreaction and facilitates allergic reaction; for another, it promotes differentiation of naturally occurring CD4+CD25+Foxp3+ regulatory T cells (nTregs) maintains immune tolerance. However, exact role in atherosclerosis remains unknown.In vitro, we examined phenotype TSLP-conditioned bone marrow dendritic (TSLP-DCs) apolipoprotein E-deficient (ApoE-/-) mice their capacity...
Introduction. Numerous studies suggest that total cholesterol content of erythrocyte membranes (CEM) might play a critical role in atherosclerotic plaque progression and instability. However, the exact CEM atherosclerosis remains obscure. Our study was designed to investigate association between severity coronary artery disease (CAD), assess effect rosuvastatin on levels. Methods. levels were assessed 136 participants, including acute syndrome (ACS) (non-ST-segment elevation ACS (NSTEACS)...
Objective CD4+ latency-associated peptide (LAP)+ regulatory T cells (Tregs) are a newly discovered cell subset in humans and the role of these patients with acute coronary syndrome (ACS) has not been explored. We designed to investigate whether circulating frequency function CD4+LAP+ Tregs defective ACS. Methods One hundred eleven ACS (acute myocardial infarction unstable angina) 117 control were enrolled study. The consisted chronic stable angina (CSA) chest pain (CPS). frequencies...
Atherosclerosis (AS) is an inflammatory and immune disease. Regulatory T cells (Tregs) suppress the activation of have been shown to play a protective role during pathogenesis AS. However, specific markers for Tregs are lacking. Recently, glycoprotein A repetitions predominant (GARP) was discovered as marker activated Tregs, we therefore utilized GARP surface in current study.To assess whether GARP(+) downregulated patients with acute coronary syndrome (ACS), examined CD4(+)CD25(+)GARP(+)...
Summary Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein A repetitions predominant (GARP) expressed on activated CD4 + T cells suppressive activity has been established. This study aimed to investigate frequency function circulating CD25 GARP regulatory (Treg) in DCM. Forty‐five DCM patients 46 controls were enrolled this study. There was significant increase peripheral helper type 1 (Th1) Th17...
Background: Accumulating evidence shows that the pathological autoreactive immune response is responsible for plaque rupture and subsequent onset of acute coronary syndrome (ACS). Naturally occurring CD4+CD25+regulatory T cells (nTregs) are indispensable in suppressing maintaining homeostasis. However, number suppressive function glycoprotein-A repetitions predominant (GARP) + CD4+ CD25+ activated nTregs were impaired patients with ACS. Recent suggests heme oxygenase-1 (HO-1) can regulate...
This study aimed to identify autophagy-related genes (ARGs) associated with non-obstructive azoospermia and explore the underlying molecular mechanisms.Two datasets were downloaded from Gene Expression Omnibus database, ARGs obtained Human Autophagy-dedicated Database. Autophagy-related differentially expressed identified in control groups. These subjected Ontology Kyoto Encyclopedia of Genes Genomes, protein-protein interaction (PPI) network, functional similarity analyses. After...
Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, driven immune cells and cytokines. Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties diseases. However, precise mechanisms of IL-27, especially atherosclerosis remains unknown. In our research, we examined influence administration IL-27 an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both initiation progression atherosclerosis. groups (both progression) receiving recombinant...
Neutrophil extracellular traps (NETs) are important factors in initiating and perpetuating inflammation. However, the role of NETs different subtypes juvenile idiopathic arthritis (JIA) has been rarely studied. Therefore, we aimed to explore ability JIA-derived neutrophils release effect TNF-α (tumor necrosis factor-alpha) inhibitors on NET formation both
Background:Atherosclerosis is an inflammatory disease involving activation of adaptive and innate immune responses to antigens, including oxidized low-density lipoprotein (oxLDL) phosphorylcholine (PC). Dendritic cells (DCs), which are antigen-presenting that activate T cells, present in atherosclerotic lesions activated organs. However, the mechanism by PC promotes atherosclerosis unclear.
Abstract Objective： Coronary artery disease (CAD) is an immune-mediated chronic disease, and interleukin-27(IL-27) regulates CD4 + T cell differentiation. However, little known about its effects on CAD. Therefore, we aimed to investigate the changes of IL-27 effect cells in patients with Methods: The severity coronary stenosis was assessed by Gensini score, concentrations plasma IL-27, ox-LDL were measured ELISA. qRT-PCR Western Blotting (WB) performed evaluate mRNA protein expression T-bet,...