A5089935373- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Sperm and Testicular Function
- Ferroptosis and cancer prognosis
- Reproductive Biology and Fertility
- Viral Infectious Diseases and Gene Expression in Insects
- Viral gastroenteritis research and epidemiology
- T-cell and Retrovirus Studies
- Extracellular vesicles in disease
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Immunology Research
- Bladder and Urothelial Cancer Treatments
- Ovarian function and disorders
Harbin Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
First People's Hospital of Jingzhou
2024
Foshan Maternity and Child Health Care Hospital
2022-2023
Southern Medical University
2022-2023
Disulfidptosis is a newly discovered mode of cell death. However, its biological mechanism in bladder cancer (BLCA) still uncharacterized. In this investigation, we firstly examined the expression and mutation disulfidptosis-related genes (DRGs) BLCA. Two disulfidptosis phenotypes associated with DRGs patterns immune infiltration were built. A risk score signature was constructed based on ten differentially expressed (DEGs) between subtypes, which allowed patients to be stratified into high-...
Cell-passage-adapted strains of African swine fever virus (ASFV) typically exhibit substantial genomic alterations and attenuated virulence in pigs. We have indicated that the HEK293T cells-adapted ASFV strain underwent genetic I7L gene right variable region was deleted compared with HLJ/2018 (ASFV-WT). A recent study has revealed deletion - I11L genes results attenuation virulent vivo , but underlying mechanism remains largely unknown. Therefore, we hypothesized may be related to...
Background: Non-obstructive azoospermia (NOA) is the most severe form of male infertility. Currently, molecular mechanisms underlying NOA pathology have not yet been elucidated. Hence, elucidation and exploration potential biomarkers are essential for accurate diagnosis treatment this disease. In present study, we aimed to screen pathways involved in reveal their using integrated bioinformatics. Methods: We downloaded two gene expression datasets from Gene Expression Omnibus (GEO) database....
Background: Hepatocellular carcinoma is a highly malignant tumor with significant heterogeneity. Metabolic reprogramming plays an essential role in the progression of hepatocellular carcinoma. Among them, nucleotide metabolism needs further investigation. Methods: Based on bioinformatics approach, eleven prognosis-related genes were screened this study. Lasso-Cox regression method, we finally identified prognostic model containing six and calculated risk score for each patient. In addition,...
This study aimed to identify autophagy-related genes (ARGs) associated with non-obstructive azoospermia and explore the underlying molecular mechanisms.Two datasets were downloaded from Gene Expression Omnibus database, ARGs obtained Human Autophagy-dedicated Database. Autophagy-related differentially expressed identified in control groups. These subjected Ontology Kyoto Encyclopedia of Genes Genomes, protein-protein interaction (PPI) network, functional similarity analyses. After...
The B169L protein (pB169L) of African swine fever virus (ASFV) is a structural with an unidentified function during the replication. sequences gene and downstream B438L are separated by short intergenic regions. However, regulatory mode transcription remains unknown. Here, we identified two distinct promoter regions start sites (TSS) located upstream open reading frame (ORF) B438L. Using reporter system, demonstrated that cis activity ORF proximal exhibited significantly higher levels...
The B169L protein (pB169L) of African swine fever virus (ASFV) is a structural with an unidentified function during the replication. sequences
African swine fever (ASF), caused by virus (ASFV), is a devastating infectious disease of domestic pigs and wild boar, which threatens the global pig industry. Endoplasmic reticulum (ER) multifunctional signaling organelle in eukaryotic cells that involved protein synthesis, processing, posttranslational modification quality control. As intracellular parasitic organisms, viruses have evolved several strategies to modulate ER functions favor their life cycles. We previously demonstrated...