A5100660467- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- Cholinesterase and Neurodegenerative Diseases
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Chromatography in Natural Products
- Receptor Mechanisms and Signaling
- Pancreatic and Hepatic Oncology Research
- Computational Drug Discovery Methods
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Analytical Chemistry and Chromatography
- MRI in cancer diagnosis
- Cannabis and Cannabinoid Research
- Diabetes and associated disorders
- Advanced Proteomics Techniques and Applications
- Renal cell carcinoma treatment
- Natural product bioactivities and synthesis
- Remote Sensing and Land Use
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
Chinese Academy of Sciences
1998-2025
State Key Laboratory of Polymer Physics and Chemistry
2025
Changchun Institute of Applied Chemistry
2025
Tianjin University of Traditional Chinese Medicine
2022-2024
First Hospital of China Medical University
2009-2024
Tianjin haihe hospital
2024
Qingdao Agricultural University
2023-2024
Foshan Maternity and Child Health Care Hospital
2022-2023
KU Leuven
2020-2022
China Medical University
2010-2022
Two offline multidimensional chromatography/high-resolution mass spectrometry systems (method 1: fractionation and online two-dimensional liquid chromatography, 2D-LC; method 2: 2D-LC) were established to characterize the metabolites simultaneously from three Glycyrrhiza species. Ion exchange chromatography in first-dimensional (1D) separation was well fractionated between acidic (mainly triterpenoids) weakly components (flavonoids). These obtained subsamples got sophisticated by second (2D)...
Small bowel volvulus is a rare disease, which also challenging to diagnose. The aims of this study were characterize the clinical and radiological features associated with small treatment identify risk factors for necrosis.Patients who underwent operations from January 2001 December 2015 at First Affiliated Hospital China Medical University (Shenyang, China) reviewed. Clinical, surgical postsurgical data registered analyzed.Thirty-one patients included analysis. Fifteen female (48.4%), an...
The traditional trial-and-error approach, although effective, is inefficient for optimizing rubber composites. latest developments in machine learning (ML)-assisted methodologies are also not suitable predicting and composite properties. This due to the dependency of properties on processing conditions, which prevents alignment data collected from different sources. In this work, a novel workflow called ML-enhanced approach proposed. integrates orthogonal experimental design with symbolic...
Decline of cognitive function is the hallmark Alzheimer's disease (AD), regardless pathological mechanism. Traditional Chinese medicine has been used to combat impairments and shown improve learning memory. Radix Polygalae (RAPO) a typical widely herbal medicine. In this study, we aimed follow β-amyloid (Aβ) reduction activity identify active constituent(s) RAPO. We found that Onjisaponin B RAPO functioned as suppress Aβ production without direct inhibition β-site amyloid precursor protein...
A field experiment was designed to assess the impacts of various maize straw (stover) returning methods on basic soil physicochemical properties and quality index in Jilin (NE China). The five treatments were no return residues (CK), incorporated evenly into using crashing-ridging technique (EIS), mulching (SM), plowed (SP), returned granulated form (SG). Relative return, EIS effectively reduced bulk density penetration resistance, increased total organic carbon (TOC),...
Alzheimer's disease (AD) is a progressive neurodegenerative that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment symptomatic intervention alternatives against AD. Smart Soup (SS), Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) Polygalae (RP), typical prescription memory deficits. Here, we assessed the efficacy SS Oral administration ameliorated cognitive...
Despite decades of intense global effort, no disease-modifying drugs for Alzheimer's disease have emerged. Molecules targeting catalytic activities γ-secretase or β-site APP-cleaving enzyme 1 (BACE1) been beset by undesired side effects. We hypothesized that blocking the interaction between BACE1 and subunit presenilin-1 (PS1) might offer an alternative strategy to selectively suppress Aβ generation. Through high-throughput screening, we discovered 3-α-akebonoic acid (3AA) interferes with...
Ginseng extracts are extensively used as raw materials for food supplements and herbal medicines. This study aimed to characterize ginsenosides obtained from six Panax plant (Panax ginseng, red quinquefolius, notoginseng, japonicus, japonicus var. major) compared them with their in vitro metabolic profiles mediated by rat intestinal microbiota. Ultrahigh-performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) scheduled multiple reaction...
Abstract Proteome profile changes in Alzheimer's disease (AD) brains have been reported. However, it is unclear whether they represent a continuous process, or there sequential involvement of distinct proteins. To address this question, we used mass spectrometry. We analyzed soluble, dispersible, sodium dodecyl sulfate, and formic acid fractions neocortex homogenates (mainly Brodmann area 17‐19) from 18 pathologically diagnosed preclinical AD, 17 symptomatic cases without signs...
Abstract Alzheimer’s disease is neuropathologically characterized by the deposition of amyloid β-peptide (Aβ) as plaques. Aβ plaque pathology starts in neocortex before it propagates into further brain regions. Moreover, aggregates undergo maturation indicated occurrence post-translational modifications. Here, we show that propagation plaques led presumably non-modified followed aggregate maturation. This sequence was seen human brains and precursor protein transgenic mice receiving...
γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines generation Aβ which is associated with Alzheimer's disease (AD). Here we identified that an anti-Parkinson's drug, Istradefylline, could enhance in various cell lines primary neuronal cells APP/PS1 mouse. Moreover, increased Aβ42 was detected cortex mouse after chronic treatment Istradefylline. Istradefylline promoted activity lead to production. These effects were reduced by knockdown A2AR...
Metabolic dysregulation underlies key metabolic risk factors—obesity, dyslipidemia, and dysglycemia.To uncover mechanistic links between metabolomic by testing metabolite associations with factors cross-sectionally factor changes over time.Cross-sectional—discovery samples (n = 650; age, 36–69 years) from the Framingham Heart Study (FHS) replication 670; 61–76 BioImage Study, both following a factorial design sampled high vs low strata of body mass index, lipids, glucose. Longitudinal—FHS...
(1) Background: The Hypsizygus marmoreus is a popular edible mushroom in East Asian markets. In previous study, we reported the proteomic analyses of different developmental stages H. marmoreus, from primordium to mature fruiting body. However, growth and protein expression changes scratching are unclear. (2) Methods: A label-free LC-MS/MS quantitative analysis technique was adopted obtain profiles three groups samples collected tenth day after scratching. Pearson’s correlation coefficient...
Compatibility with the varying prescription ratios is a unique feature in Chinese medicine practice. Sishen formula (SSF; containing Psoraleae Fructus-PF, Myristicae Semen-MyS, Schisandrae Chinensis Fructus-SCF, and Euodiae Fructus-EF) different proportions has been used to treat irritable bowel syndrome, however, underlying chemical difference needs be clarified, particularly influence on extracting those known toxic components. To tackle this issue, an integrated strategy was developed: 1)...
Although levodopa is the first-line medication for treatment of Parkinson's disease (PD) showing unsurpassable efficiency, its chronic use causes dyskinesia. Accordingly, dopamine agonists are increasingly employed as monotherapy or in combination with to reduce risk motor complications. It well recognized that patients PD often exhibit cognitive deficits. However, clinical and animal studies assessing effects dopaminergic medications on cognition controversial. Amyloid-β (Aβ) one major...
Purpose The purpose of this study was to develop and validate a preoperative nomogram differentiating benign malignant gallbladder polypoid lesions (GPs) combining clinical radiomics features. Methods imaging data 195 GPs patients which were confirmed by pathology from April 2014 May 2021 reviewed. All randomly divided into the training testing cohorts. Radiomics features based on 3 sequences contrast-enhanced computed tomography extracted Pyradiomics package in python, further combined with...