A5100762284- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Oral microbiology and periodontitis research
- Chemokine receptors and signaling
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- Diabetic Foot Ulcer Assessment and Management
- Immune cells in cancer
- Immune Response and Inflammation
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Biological and pharmacological studies of plants
- Heart rate and cardiovascular health
- Nephrotoxicity and Medicinal Plants
- Blood Pressure and Hypertension Studies
- Antimicrobial Peptides and Activities
- Essential Oils and Antimicrobial Activity
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Traditional Chinese Medicine Analysis
- Heme Oxygenase-1 and Carbon Monoxide
Stomatology Hospital
2024
Capital Medical University
2011-2024
Beijing Anzhen Hospital
2011-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Huazhong Agricultural University
2021
Cornell University
2020
Ministry of Education of the People's Republic of China
2015
Southwest University
2015
Innate immune and inflammatory responses are involved in myocardial ischaemia/reperfusion (I/R) injury. Interleukin (IL)-37 is a newly identified member of the IL-1 family, functions as fundamental inhibitor innate immunity inflammation. However, its role I/R injury remains unknown. or sham operations were performed on male C57BL/6J mice. mice received an injection recombinant human IL-37 vehicle, immediately before reperfusion. Compared with vehicle treatment, treated showed obvious...
More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting IL-37 is involved atherosclerosis-related diseases. However, plasma levels patients with acute syndrome (ACS, including unstable angina pectoris myocardial infarction) have yet to be investigated.Plasma IL-37, IL-18, IL-18BP were measured 50 stable (SAP), 75 (UAP), 67 infarction (AMI), 65 control...
Background . Evidence from experimental studies showed that Th1, Th2, and Th17 play a pivotal role in hypertension target organ damage. However, whether changes the circulating levels are associated with nondipper carotid atherosclerotic plaque has yet to be investigated. Methods were detected using flow cytometric analysis, their related cytokines measured by enzyme-linked immunosorbent assay 45 hypertensive patients 15 normotensive subjects. Results The frequencies of Th1 patients,...
Our previous study indicated that interleukin (IL)-37 is involved in atherosclerosis. In the present study, Anterior tibial arteries were collected from diabetes patients and controls. A histopathological analysis showed IL-37 was over-expressed human atherosclerotic plaques. Many types of cells including macrophages, vascular smooth muscle (VSMCs), endothelial T lymphocyte expressed ApoE-/- mice divided into a control group recombinant IL-37-treated group. The treatment resulted significant...
Interleukin (IL)-37 is a newly discovered member of the cytokine IL-1 family. Recent evidence suggests that IL-37, an anti-inflammatory factor, may have role in atherosclerosis. In this study we used apoE-deficient diabetic mice, established animal model, to examine effects IL-37 on progression vascular calcification and Compared with control groups, IL-37-treated (with injection recombinant protein for 16 weeks) animals had significantly less areas detected by both von Kossa Alizarin Red...
Renal ischemia-reperfusion (I/R) injury is an inevitable complication during renal transplantation and closely related to patient prognosis. Mitochondrial damage induced oxidative stress the core link of I/R injury. Ligustilide (LIG), a natural compound extracted from ligusticum chuanxiong hort angelica sinensis, has exhibited potential protect mitochondrial function. However, whether LIG can ameliorate requires further investigation. Delving deeper into precise targets mechanisms LIG's...
Valsartan has a protective effect against hypertension and atherosclerosis in humans experimental animal models. This study aimed to determine the of prolonged treatment with angiotensin II (Ang II) on valsartan activity CD4(+) T lymphocyte subsets. The results showed that (8 wks) exogenous Ang resulted an increased atherosclerotic plaque size switch stable-to-unstable via modulating activity, including increase helper cell type 1 (Th1) Th17 cells decrease Th2 regulatory (Treg) cells. In...
Chemerin15 (C15), an endogenous anti-inflammatory component, inhibits the activity of neutrophils and macrophages through G protein-coupled receptor ChemR23; however, its role as well functional mechanism in mouse myocardial ischemia/reperfusion (I/R) injury remains unknown. Methods. Sham or I/R operations were performed on C57BL/6J mice. The mice received injection C15 immediately before reperfusion. Serum troponin T levels, infarct size, cardiomyocyte apoptosis, reactive oxygen species...
Abstract Background B cell activating factor (BAFF) is a member of the tumor necrosis (TNF) superfamily with immunomodulatory effects on both innate and adaptive immune responses. Periodontitis an inflammatory disease characterized by periodontal soft tissue inflammation progressive loss ligament alveolar bone. Macrophages are closely related to periodontitis progression. However, role BAFF in development macrophage polarization underlying mechanism remain unknown. Methods In vivo,...
There is no reliable way to identify the high-risk patients with intermediate coronary artery lesions (diameter stenosis 20%-70%) in early stage. Soluble CXC chemokine ligand 16 (CXCL16) a newly discovered that can mediate inflammatory responses. It released by proteolytic cleavage of its membrane-bound form, named scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX) promote uptake low-density cholesterol macrophages. We have hypothesized CXCL16 an indicator prognosis...
BACKGROUND M1 polarization of macrophages is an important pathological process in myocardial ischemia reperfusion injury, which the major obstacle for treatment acute infarction. Currently, strategies and mechanisms inhibiting M1 are poorly explored. This study aims to investigate role soluble death receptor 5-Fc (sDR5-Fc) regulating under extreme conditions explore from aspect glycolysis. METHODS Extreme were induced RAW264.7 cells. Real-time quantitative polymerase chain reaction western...
经皮冠状动脉介入治疗已成为临床上心肌血运重建的标准和重要手段，总体呈现递增趋势。本文将从“经常规桡动脉途径和远端桡动脉途径入路比较”“腔内影像学指导的冠心病介入治疗”“无创冠状动脉影像功能学评价”“急性心肌梗死急诊冠状动脉介入治疗”等几个方面，对近十年来冠状动脉病变介入治疗的研究进展和热点问题进行探讨。.
Remnant cholesterol (RC) exert a significant influence on atherosclerotic cardiovascular disease development. However, the prognostic implications of RC in menopausal women received percutaneous coronary intervention (PCI) who experiencing acute syndrome (ACS) remain uncertain.
Abstract Background Prediabetes, impacting approximately 10% of adults, lacks comprehensive attention, and there is limited data on effective glycemic control strategies. Meta-analysis suggests that intensive linked to a lower incidence major adverse cardiovascular events, mainly driven by decreased reinfarction reduced microvascular complications in coronary artery disease (CAD) patients. However, despite these associations, existing evidence does not conclusively establish the efficacy...
Objective: To compare the efficacy and safety of active transfer plaque (ATP) versus provisional stenting (PS) with drug-eluting stents (DES) for treatment coronary bifurcation lesions. Methods: A total 1 136 patients lesions hospitalized in 6 selected hospitals between January 2010 2014 were included this prospective observational trial, divided into either ATP (n=560) or PS group (n=576) accordingly. The primary endpoint was target lesion revascularization within year, second endpoints...
The integration of robust data analysis into the financial markets has allowed firms to develop more efficient and accurate algorithms for predicting behavior individual firms. This been most effective with large comprehensive sets. However, ease these types sets led their widespread adoption diminished usefulness in markets. valuable then exists forms that are difficult use have not used by majority market. purpose this project is integrate foot traffic from stores a quantitative...
Abstract Background Atherosclerosis (AS) is a systemic disease and the common cause of heart attacks, strokes peripheral vascular collectively referred to as cardiovascular diseases (CVD). In AS plaques, CD44 upregulated functionally activated on endothelial cells, smooth muscle macrophages. YN001 liposome encapsulated Rosuvastatin calcium which was initially approved for reduction cholesterol levels slowing progression atherosclerosis. being developed treatment by targeted enrichment in...