A5091158151- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aortic Thrombus and Embolism
- Venous Thromboembolism Diagnosis and Management
- Frailty in Older Adults
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Monoclonal and Polyclonal Antibodies Research
- Gout, Hyperuricemia, Uric Acid
- Nitric Oxide and Endothelin Effects
- CNS Lymphoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Chronic Kidney Disease and Diabetes
- Chemokine receptors and signaling
Capital Medical University
2014-2025
Beijing Anzhen Hospital
2014-2025
Hubei University of Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
JGC Catalysts and Chemicals (Japan)
2016
Columbia University Irving Medical Center
2009-2013
Cardiovascular Research Foundation
2009-2013
Capital University
2008
University of Pittsburgh
2001-2003
University Hospital of Basel
2000
Abstract Background Findings from earlier research have established that insulin resistance (IR) is implicated in atherosclerosis progression, representing a noteworthy risk factor for cardiovascular disease (CVD). Recently, the triglyceride glucose-body mass index (TyG-BMI) has been introduced as straightforward and robust alternative indicator early detection of IR. Nevertheless, there scarcity studies examined capability TyG-BMI predicting incident CVD. Consequently, core objective this...
Background The FAVOR III (Comparison of Quantitative Flow Ratio Guided and Angiography Percutaneous Intervention in Patients With Coronary Artery Disease) China trial reported improved clinical outcomes with percutaneous coronary intervention guided by quantitative flow ratio (QFR) compared angiography. Whether these benefits also apply for patients presenting “uncertainty‐zone” lesions intermediate physiological significance is uncertain. This study aims to examine the impact QFR guidance...
The fact that hypertension is associated with atherosclerotic cardiovascular disease in the elderly has been confirmed. However, very little known about its impact on severity of coronary artery lesions young people, especially women. To evaluate effect essential (EH) women acute syndrome (ACS), and to provide a reference for clinical prevention treatment. From January 2003 2022, 5220 (aged ≤ 44 years) who underwent angiography (CAG) due chest pain symptoms were retrospectively analyzed,...
Arterial stiffness has been confirmed to be associated with cognitive impairment. Carotid-femoral pulse wave velocity (cfPWV) is widely regarded as the gold standard for assessing arterial stiffness, yet it not readily accessible. In response, use of estimated (ePWV) proposed a more accessible and cost-effective alternative. ePWV only offers ease calculation but also covers broader spectrum vascular aging processes, some which may distinct from those detected by cfPWV. The aim our study was...
Insulin resistance (IR) is closely linked to cardiometabolic diseases. Preventing and improving IR in nondiabetic populations critically important. We aimed investigate the relationship between Life's Essential 8 (LE8), latest tool from American Heart Association quantifying cardiovascular health, among United States.
Abstract Background This article aims to investigate the changes of plasma cystatin C concentration (PcyC), and evaluate relationship between PcyC acute coronary syndrome. Methods A total 126 consecutive patients with artery disease (CAD) were enrolled in this study, consisting 34 stable angina pectoris (SAP), 56 unstable (UAP), 36 myocardial infarction (AMI), healthy subjects as controls. Plasma C, high sensitivity C‐reactive protein (hs‐CRP), cholesterol (TC), low‐density lipoprotein...
Virtual histology intravascular ultrasound (VH-IVUS) allows detailed assessment of plaque composition in the clinical setting. Optical coherence tomography (OCT) has been developed as a high-resolution imaging method, which might be promising technique to identify thin-cap fibroatheroma (TCFA) vivo. The purpose present study was evaluate diagnostic accuracy VH-IVUS TCFA determined by OCT.We examined 96 target lesions patients with stable angina pectoris using and OCT. derived defined focal...
Objectives In recent years, the free triiodothyronine/free thyroxine (FT3/FT4) ratio, a new comprehensive index for evaluating thyroid function, which could reflect function more stably and truly than serum hormone level, has been demonstrated to correlate with risks of diabetes cardiovascular disease in euthyroid adults. However, correlation between sensitivity long-term prognosis patients acute coronary syndrome (ACS) after percutaneous intervention (PCI) remains unclear. Methods A total...
Pregnancy-associated plasma protein-A (PAPP-A) level is an independent predictor of acute cardiovascular event occurrence. To test the hypothesis that increased PAPP-A levels would be associated with a higher burden coronary thin-cap fibroatheroma (TCFA) thereby underlying heightened risk for events in patients artery disease; 154 (462 vessels and 975 plaques) stable angina or non-ST-segment elevation syndrome (NSTE-ACS) referred percutaneous intervention were assessed using 3-vessel virtual...
Abstract Background The associations between the long-term triglyceride-glucose (TyG) index level and variability clinical outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI) have not been well studied. Methods A total of 1,694 ACS at least three postbaseline TyG measurements within 2 years after PCI were included present study. was defined as ln (fasting triglycerides [mg/dL] × fasting plasma glucose [mg/dL]/2). Multivariable-adjusted Cox...
To evaluate the long-term outcome after re-attempt CTO-PCI.This is a retrospective cohort study that included 113 CTO-PCI patients who were consecutively registered from January 2019 to December 2020 at Beijing Anzhen Hospital's Center of Coronary Artery Disease. All divided into two groups based on procedural success or failure. The primary endpoint was major adverse cardiac events (MACE), composite all-cause mortality, myocardial infarction and target vessel revascularization (TVR)....
Increased susceptibility to malnutrition and inadequate glycemic control are frequently observed in diabetic patients with coronary artery disease. The assessment of is performed using the prognosis nutritional index (PNI). measured glycated hemoglobin (HbA1c). However, combined effect PNI HbA1c on disease remains unknown.
There is no reliable way to identify the high-risk patients with intermediate coronary artery lesions (diameter stenosis 20%-70%) in early stage. Soluble CXC chemokine ligand 16 (CXCL16) a newly discovered that can mediate inflammatory responses. It released by proteolytic cleavage of its membrane-bound form, named scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX) promote uptake low-density cholesterol macrophages. We have hypothesized CXCL16 an indicator prognosis...
Herein, we first prepared a novel anti-TROP2 antibody-drug conjugate (ADC) hIMB1636-MMAE using hIMB1636 antibody chemically coupled to monomethyl auristatin E (MMAE) via Valine-Citrulline linker and then reported its characteristics antitumor activity. With DAR of 3.92, it binds specifically both recombinant antigen (KD ∼ 0.687 nM) cancer cells could be internalized by target selectively kill them with IC50 values at nanomolar/subnanomolar levels inducing apoptosis G2/M phase arrest. also...