A5101555754- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Graph theory and applications
- Virus-based gene therapy research
- Effects and risks of endocrine disrupting chemicals
- Hippo pathway signaling and YAP/TAZ
- Sperm and Testicular Function
- Molecular Biology Techniques and Applications
- Advanced Graph Theory Research
- Limits and Structures in Graph Theory
- Fungal Biology and Applications
- Coronary Artery Anomalies
Ministry of Agriculture and Rural Affairs
2025
Northwest A&F University
2013-2025
Capital Medical University
2013-2025
Beijing Anzhen Hospital
2013-2025
Tianjin Medical University
2022-2024
Zhengzhou University
2023-2024
Gansu Provincial Hospital
2023-2024
King's College London
2024
Gansu University of Traditional Chinese Medicine
2023
Guilin Medical University
2023
Abstract MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed several prostate cancer (PCa) stem/progenitor cell populations both xenograft primary patient tumours. Enforced expression miR-141 CD44 + bulk PCa cells inhibits stem properties including holoclone sphere formation, as well invasion, suppresses regeneration Moreover, enforces a strong epithelial phenotype with...
microRNA-128 (miR128) is reduced in prostate cancer relative to normal/benign tissues, but causal roles are obscure. Here we show that exogenously introduced miR128 suppresses tumor regeneration multiple xenograft models. Cancer stem-like cell (CSC)-associated properties were blocked, including holoclone and sphere formation as well clonogenic survival. Using a sensor distinguish cells on the basis of expression, found miR128-lo possessed higher clonal, clonogenic, tumorigenic activities...
Abstract Purpose: We have shown that the phenotypically undifferentiated (PSA−/lo) prostate cancer cell population harbors long-term self-renewing stem cells (CSC) resist castration, and a subset of within PSA−/lo bearing ALDHhiCD44+α2β1+ phenotype (Triple Marker+/TM+) is capable robustly initiating xenograft tumors in castrated mice. The goal current project to further characterize biologic properties TM+ population, particularly context propagating castration-resistant (CRPC). Experimental...
Spermatogenesis is an intricate developmental process during which undifferentiated spermatogonia, containing spermatogonial stem cells (SSCs), undergo self-renewal and differentiation to generate eventually mature spermatozoa. occurs in seminiferous tubules within the testis, harbor Sertoli germ cells. are essential somatic cell type microenvironment that support steer male development, whereas spermatogonia primitive at onset of spermatogenesis. While progression has been well established...
Melanoma cells actively participate in tumor angiogenesis and vasculogenic mimicry. However, anti-angiogenic therapy patients with melanoma has not shown a significant survival gain. Thus, new anti-melanoma angiogenic drugs are highly desired. Using the metastatic cell line C8161 as model, we explored inhibitors found that lycorine hydrochloride (LH) effectively suppressed cell-dominant formation of capillary-like tubes vitro generation blood vessels vivo low toxicity. Mechanistic studies...
Human cancers exhibit significant cellular heterogeneity featuring tumorigenic cancer stem cells (CSCs) in addition to more differentiated progeny with limited tumor-initiating capabilities. Recent studies suggest that microRNAs (miRNAs) regulate CSCs and tumor development. A previous library screening for differential miRNA expression CD44+ (and other) prostate CSC vs. non-CSC populations identified miR-199a-3p be among the most highly under-expressed miRNAs CSCs. In this study, we...
: It takes several hours for mammalian sperm to migrate from the ejaculation or insemination site fertilization in female reproductive tract which glucose, amino acids, and fatty acids are regarded as primary substrates ATP generation. The present study was designed investigate whether oleic acid palmitic were beneficial boar vitro; if yes, elucidate mechanism that regulates motility. Therefore, levels of acid, motility, membrane integrity, acrosome apoptosis evaluated. Moreover, enzymes...
Spermatogenesis is the process by which male gametes are formed from spermatogonial stem cells and it essential for reliable transmission of genetic information between generations. To date, dynamic transcriptional changes defined populations germ in pigs have not been reported.To characterize atlas porcine spermatogenesis, we profiled transcriptomes ~ 16,966 testicular a 150-day-old pig testis through single-cell RNA-sequencing (scRNA-seq). The scRNA-seq analysis identified spermatogonia,...
Background and objective Extreme haemodilution occurring with cardiopulmonary bypass imposes a primary risk factor for blood transfusion in small adult cardiac surgical patients. Priming of the circuit patients' own [retrograde autologous priming (RAP)] is technique used to limit reduce requirements. We designed this study evaluate effects RAP on reducing perioperative adults. Methods One hundred twenty patients body surface area less than 1.5 m2 undergoing first-time, nonemergency surgery...
Anti-lymphoma therapy continues to present a major challenge. Even though cytotoxic therapy, immunotherapy and molecularly targeted have been used in the clinic treat disease, effective anti-lymphoma drugs are still needed. In this study, we explored novel agents found that scutellarin, an active component of traditional Chinese medicinal herb Erigeron breviscapus, executed effect. Scutellarin diminished proliferation B-lymphoma Namalwa cells vitro inhibited lymphoma growth...
As one of the 100 worst invasive alien species in world, red imported fire ant (Solenopsis invicta Buren) is great concern because its impact on human health, economic development, and native biodiversity. With ongoing global climate change situation, there an increased public health threat from invasion S. invicta. To understand distribution suitable habitats for under current future scenarios mainland China, nine models were constructed compared to which more predict The performance Random...
Cytochrome P450 monooxygenases (P450s) play important roles in the detoxification metabolism of xenobiotics and are involved resistance insects to many insecticides. In this study, piperonyl butoxide (PBO), an inhibitor enzyme activity, significantly increased toxicity clothianidin clothianidin-resistant (CL-R) population Bradysia odoriphaga. The activity CL-R was higher than that SS population. Furthermore, four genes were found be overexpressed Tissue-specific expression analysis indicates...
Abstract Chromium (Cr) and its compounds are closely associated with individuals’ lives extensively used in industry. Excessive exposure to hexavalent chromium (Cr(VI)) induces oxidative damage of various organs including the testes, posing a serious threat male reproductive fitness. As an endogenous antioxidant, melatonin holds potent antioxidative anti-inflammatory properties, becoming potential candidate for treatment variety diseases, disorders. Here, by using mouse model, we...
The fact that hypertension is associated with atherosclerotic cardiovascular disease in the elderly has been confirmed. However, very little known about its impact on severity of coronary artery lesions young people, especially women. To evaluate effect essential (EH) women acute syndrome (ACS), and to provide a reference for clinical prevention treatment. From January 2003 2022, 5220 (aged ≤ 44 years) who underwent angiography (CAG) due chest pain symptoms were retrospectively analyzed,...
Malignant melanoma is the most aggressive form of skin cancer. Although various antimelanoma approaches have been used in clinics to treat disease over last three decades, none drugs significantly prolonged survival metastatic patients; hence, effective against are highly desired. In this study, we explored an antimetastatic agent derived from traditional Chinese medicinal herbs and found that jatrorrhizine hydrochloride (JH), active component herb Coptis chinensis, inhibited proliferation...
Hyperkinetic pulmonary arterial hypertension (PAH) severely influences the success of operation for congenital heart disease and deteriorates prognosis disease. Adipose-derived stromal cell (ADSC) is a good alternative multipotent stem regeneration medicine. PAH rat models were established by arteriovenous shunt ADSCs isolated, cultured, labeled in vitro. Twelve weeks after operation, rats received an injection 5 × 107 ADSCs. Two transplantation, hemodynamic abnormality induced flow...
Background: Although adenosine (ADO) has been shown to have beneficial effects against tissue injury after myocardial ischaemia, the controversy still remains regarding optimal timing, dose, temperature, method of ADO administration and duration exposure drug. This study investigates cardioprotective effect exogenous pretreatment as an adjunct 1 mmol l−1 cold (12 °C) blood cardioplegia during heart valve replacement surgery. Materials methods: Thirty patients with rheumatic disease...
Blue egg coloring is attributed to biliverdin derived from the oxidative degradation of heme through catalysis by oxygenase (HO). The pigment secreted into eggshell shell gland. There uncertainty as whether synthesized in gland or other tissues. To investigate site biosynthesis, expression (decycling) 1 (HMOX1), a gene encoding HO, and HO activity liver spleen were compared between blue-shelled chickens (n=12) brown-shelled (n=12). no significant differences HMOX1 these tissues two groups....
With increasing water pollution, algal bloom becomes more and frequent. To manage blooms, the exploitation study of novel algae‐lysing strains are extremely urgent. In this study, two algicidal isolates (NP23 AM11) against Chlorella pyrenoidosa were obtained from Baiguishan reservoir in China. Phylogenetic analysis 16S rDNA sequences revealed that NP23 AM11 closely related to Enterobacter cloacae Gibberella moniliformis, respectively. Moreover, determine effects these on antioxidase...
Background and Purpose: Whether imaging parameters would independently predict stroke recurrence in low-risk minor ischemic (MIS) or transient attack (TIA) according to traditional score system (such as ABCD 2 score, which was termed on the basis of initials five factors: age, blood pressure, clinical features, duration, diabetes) remains unclear. We sought evaluate association between 1-year patients with TIA MIS different risk stratum stratified by score. Methods: included (National...