A5038974675- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Psoriasis: Treatment and Pathogenesis
- Signaling Pathways in Disease
- CAR-T cell therapy research
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- RNA Research and Splicing
- Whipple's Disease and Interleukins
- Reproductive Biology and Fertility
- Medical Research and Treatments
- Ovarian function and disorders
- Aortic aneurysm repair treatments
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ocular Surface and Contact Lens
- Systemic Sclerosis and Related Diseases
- Immune cells in cancer
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- PARP inhibition in cancer therapy
- Biomarkers in Disease Mechanisms
- IL-33, ST2, and ILC Pathways
Huazhong University of Science and Technology
2016-2023
Union Hospital
2017-2023
Union Hospital
2016-2023
Wuhan Union Hospital
2019
Obstetrics and Gynecology Hospital of Fudan University
2018
First People's Hospital of Chongqing
2012
Background Excessive immune‐mediated inflammatory reactions play a deleterious role in postinfarction ventricular remodeling. Interleukin‐37 ( IL ‐37) emerges as an inhibitor of both innate and adaptive immunity. However, the exact ‐37 plus troponin I (TnI)–treated dendritic cells DC s) remodeling after myocardial infarction MI ) remains elusive. Methods Results was induced by permanent ligation left anterior descending artery. Our results showed that treatment with recombinant human...
Abstract Excessive immune‐mediated inflammatory reaction plays a deleterious role in ventricular remodelling after myocardial infarction (MI). Interleukin (IL)‐38 is newly characterized cytokine of the IL‐1 family and has been reported to exert protective effect some autoimmune diseases. However, its cardiac post‐MI remains unknown. In this study, we found that expression IL‐38 was increased infarcted heart MI induced C57BL/6 mice by permanent ligation left anterior descending artery....
Oxidative stress and subsequent cardiac myocyte apoptosis play central roles in the initiation progression of myocardial ischemia-reperfusion (I/R) injury. Homeobox transcript antisense intergenic RNA ( Hotair ) was previously implicated various heart diseases, yet its role I/R injury has not been clearly demonstrated. Mice with cardiac-restricted knockdown or overexpression were exposed to surgery. H9c2 cells cultured subjected hypoxia/reoxygenation (H/R) stimulation further verify...
Background . Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity. However, the exact role IL-37 in patients with acute coronary syndrome (ACS) remains to be elucidated. Methods Patients were classified into 4 groups: normal artery (NCA), stable angina (SA), unstable (UA), myocardial infarction (AMI). The circulating Treg, Th1, Th17 frequencies measured. effect on stimulated peripheral blood mononuclear cells (PBMCs) influence DCs explored. In addition, IL-37-treated...
Summary Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein A repetitions predominant (GARP) expressed on activated CD4 + T cells suppressive activity has been established. This study aimed to investigate frequency function circulating CD25 GARP regulatory (Treg) in DCM. Forty‐five DCM patients 46 controls were enrolled this study. There was significant increase peripheral helper type 1 (Th1) Th17...
Irregular expression of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) is involved in the development polycystic ovary syndrome (PCOS). Activation cAMP/protein kinase (PKA)/cAMP response element-binding protein (CREB) pathway plays a crucial role FSH regulation CYP19A1 human ovarian granulosa cells. A-Kinase anchor 95 (AKAP95) known to confine PKA nucleus. However, it unclear whether anchoring nucleus essential for induction by Using cell line KGN and primary cultured luteinised...
Background. Our previous studies have shown that interleukin- (IL-) 37 plays a protective role in patients and animal models with coronary artery disease. However, the of IL-37 abdominal aortic aneurysm (AAA), another disease, is yet to be elucidated. Methods Results. AAA tissues plasma samples were obtained from or without surgical intervention. Normal renal collected kidney transplant donors. findings established AAA, was distributed endothelial cells, macrophages, vascular smooth muscle...
Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, driven immune cells and cytokines. Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties diseases. However, precise mechanisms of IL-27, especially atherosclerosis remains unknown. In our research, we examined influence administration IL-27 an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both initiation progression atherosclerosis. groups (both progression) receiving recombinant...
Rationale: A persistent autoimmune and inflammatory response plays a critical role in the progression of atherosclerosis. The transcription factor forkhead box P3 (Foxp3)+CD4+ regulatory T cells (Foxp3+ Tregs) attenuate Latency-associated peptide (LAP)+CD4+ are new class Tregs whose atherosclerosis is unknown.Objective: To investigate function CD4+LAP+ inhibiting inflammation preventing atherosclerosis.Methods Results: Depletion results aggravated atherosclerotic lesions. Mechanistically,...
Abstract Objective： Coronary artery disease (CAD) is an immune-mediated chronic disease, and interleukin-27(IL-27) regulates CD4 + T cell differentiation. However, little known about its effects on CAD. Therefore, we aimed to investigate the changes of IL-27 effect cells in patients with Methods: The severity coronary stenosis was assessed by Gensini score, concentrations plasma IL-27, ox-LDL were measured ELISA. qRT-PCR Western Blotting (WB) performed evaluate mRNA protein expression T-bet,...
This study aims to clarify the specific mechanism by which GARP affects atherosclerotic plaques in ApoE-/- mice and effect of GARP-tDC on atherosclerosis.The were randomly divided into three groups: control group, GARP-overexpressed group GARP-inhibited group. After 12 weeks, all euthanized, specimens collected. In vitro, experiments conducted observe DC phenotype changes proportion CD4+CD25+Foxp3+ Treg cells when GARP-tDCs co-cultured with CD4+ T cells. Furthermore, adoptive transmission...