A5010851719- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Hematological disorders and diagnostics
- Childhood Cancer Survivors' Quality of Life
- Polyomavirus and related diseases
- Inflammasome and immune disorders
- Neurogenetic and Muscular Disorders Research
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- Medical and Biological Ozone Research
- Immunotherapy and Immune Responses
- Transplantation: Methods and Outcomes
- Immune Response and Inflammation
Chinese PLA General Hospital
2019-2025
PLA Navy General Hospital
2013-2015
Chinese People's Liberation Army
2007
Guangzhou Blood Center
2006-2007
Guangzhou Medical University
2007
ABSTRACT In children, hyper‐IgM syndrome type 1 (HIGM1) is a of severe antibody disorder, the pathogenesis which remains unclear. The diversity partially determined by alternative splicing (AS) in germline, mainly regulated RNA‐binding proteins, including Breast cancer amplified sequence 2 (Bcas2). However, effect Bcas2 on AS and production activated B cells, main immune cell unknown. To fill this gap, we created conditional knockout (cKO, cell‐specific AID‐Cre fl/fl ) mouse model performed...
Abstract In a multicenter study, we have conducted retrospective study on 73 pediatric AML patients who were primary refractory or in greater than CR 1 and investigated MSD (or MMSD ) (n = 20), URD 23), UCB 30) HCT between January 1998 October 2009. The median day to neutrophil engraftment was similar all groups. platelet longer the group. number of HLA mismatch higher group (p 0.034); however, cumulative incidence grade III–IV aGVHD not different among groups 0.125); furthermore, cGVHD...
Hematopoietic stem cell transplantation (HSCT) is curative in patients with primary immunodeficiency syndrome. The safety and efficacy of HSCT as a therapeutic option for diseases (PID) have been studied by many research groups. purpose our study was to perform bibliometric analysis on the treatment PID, assess trends this field, note future priorities. Web Science Core Collection (WOSCC) used identify relevant publications. VOSviewer CiteSpace software were analyze parameters, such yearly...
HLA-DPB1*1497:01 differs from HLA-DPB1*05:01:01:01 by one nucleotide in exon 4.
Objective: To evaluate the outcome of combination haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) with an unrelated cord blood unit for severe aplastic anemia (SAA). Methods: The clinical data 127 SAA patients [including 74 male and 53 female patients, 65 very (vSAA), median age as 23.5(3-54) years] received HID-HSCT from September 2011 to April 2017 were analyzed retrospectively. interval diagnosis was 2 (0.5-180) months. conditioning modified Bu/Cy+ATG/ALG-based...
Objective: To investigate the efficacy of haplotype hematopoietic stem cell transplantation in treatment acquired severe aplastic anemia (SAA) children. Methods: The clinical characteristics 59 pediatric patients with SAA, including 26 cases VSAA, 37males and 22 females, 47 typeⅠ 12 typeⅡ, undrerwent haplo-HSCT our hospital between December 1st, 2011 2017 were retrospectively analyzed. Among patients, 56 a median age 4.5 (1.2-14.8) years weight 43 (12-80) kg underwent their first HSCT 3...
Unmanipulated haploid HSCT for SAA has resulted in improved outcomes over recent years. However, studies related to unmanipulated HSCs combined with tp-UCB transplantation other types of NMD are rare. Accordingly, we present the 109 pediatric patients life-threatening undergoing transplantation.We retrospectively investigated treated a single center.The median days neutrophil and platelet engraftment were +13 +22 days, respectively. None cases experienced PGF. The incidence rates grade I-II,...
Objective: To explore the impact on prognosis in favorable-risk acute myeloid leukemia (AML) patients with different consolidation regimens after first complete remission (CR(1)). Methods: A total of 107 cases non-refractory adult AML from January 2010 to June 2015 single center were enrolled study. HD-Ara-C group (38 cases) as control group, we three regimens, including micro-transplantation (16 , autologous transplantation (auto-PBSCT, 14 allogeneic (allo-HSCT, 39 cases). Results: Of (59...
Objective: To probe the feasibility of decitabine (DAC) combined with micro-transplantation as consolidation treatment for older patients acute myeloid leukemia (AML). Methods: Between November 2012 and September 2015, 37 consecutive AML ≥60 years age were analyzed. Of them, 19 received therapy DAC followed by (microtransplant group). Another 18 ones (chemo group) treated plus priming regimen chemotherapy in same period. Results: There no significant differences terms age, WBC count, disease...