A5100599924- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Brain Tumor Detection and Classification
- Advanced Glycation End Products research
- Animal Disease Management and Epidemiology
- T-cell and B-cell Immunology
- Connexins and lens biology
- Cardiac Valve Diseases and Treatments
- Epilepsy research and treatment
- Animal Virus Infections Studies
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Congenital Heart Disease Studies
- Glaucoma and retinal disorders
- Hepatitis B Virus Studies
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Aortic Disease and Treatment Approaches
- Plant Pathogens and Fungal Diseases
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Functional Brain Connectivity Studies
- Cancer Mechanisms and Therapy
- BRCA gene mutations in cancer
- Occupational and environmental lung diseases
First Affiliated Hospital of Zhengzhou University
2024-2025
China Agricultural University
2006-2025
Southwest Medical University
2022-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Cleveland Clinic
2024
Case Western Reserve University
2024
China Medical University
2022-2024
First Hospital of China Medical University
2022-2024
Soochow University
2022
Abstract Objective We aim to improve focal cortical dysplasia (FCD) detection by combining high‐resolution, three‐dimensional (3D) magnetic resonance fingerprinting (MRF) with voxel‐based morphometric imaging (MRI) analysis. Methods included 37 patients pharmacoresistant epilepsy and FCD (10 IIa, 15 IIb, 10 mild Malformation of Cortical Development [mMCD], 2 mMCD oligodendroglial hyperplasia [MOGHE]). Fifty‐nine healthy controls (HCs) were also included. 3D lesion labels manually created....
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is one of the main subtypes esophageal with high morbidity. This study aimed to explore role FKBP prolyl isomerase 11 (FKBP11) in ESCC and investigate underlying mechanism. FKBP11 levels tumor tissues lines were measured. Cell function assays conducted evaluate cells. The xenograft mouse model was established validate effect on tumorigenesis vivo. co‐immunoprecipitation assay performed determine FKBP11‐interacting proteins. Obvious...
ABSTRACT In children, hyper‐IgM syndrome type 1 (HIGM1) is a of severe antibody disorder, the pathogenesis which remains unclear. The diversity partially determined by alternative splicing (AS) in germline, mainly regulated RNA‐binding proteins, including Breast cancer amplified sequence 2 (Bcas2). However, effect Bcas2 on AS and production activated B cells, main immune cell unknown. To fill this gap, we created conditional knockout (cKO, cell‐specific AID‐Cre fl/fl ) mouse model performed...
ABSTRACT The cell populations, particularly subpopulations, involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) remain incompletely understood. This study employed single‐cell RNA‐seq to identify populations subpopulations with significantly altered proportions lungs patients IPF. In IPF lungs, endothelial were increased, while alveolar epithelial markedly decreased. Among three identified fibroblast proportion myofibroblasts was other two subtypes reduced....
Background Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis remains not fully elucidated. Inflammation metabolic dysregulation are considered to play crucial roles in LUAD development, but their causal relationships specific mechanisms remain unclear. Methods This study employed a two-sample Mendelian randomization (MR) approach systematically evaluate associations between 91 circulating inflammatory factors, 1,400 serum metabolites, LUAD. We utilized...
According to the Barcelona Clinic Liver Cancer (BCLC) system, radical resection of early stage primary hepatocellular carcinoma (HCC) mainly includes liver transplantation, surgical resection, and radiofrequency ablation (RFA), which yield 5-year survival rates about 70-79%, 41.3-69.5%, 40-70%, respectively. The tumor-free rate for HCC patients undergoing only reach up 13.7 months, so prevention recurrence after is very important prognosis patients. traditional Chinese medicine (TCM) takes...
Few studies have investigated the impact of primary tumor resection (PTR) on patients with distant metastasis medullary thyroid carcinoma (DMMTC). This population-based study aims to assess application PTR in DMMTC patients, ascertain its benefits, and identify optimal surgical indications. Patients diagnosed between 2010 2020 were included through Surveillance, Epidemiology, End Results (SEER) program. Logistic regression analysis identified driving factors decision-making. Propensity score...
Objective To develop a multiparametric machine‐learning (ML) framework using high‐resolution 3 dimensional (3D) magnetic resonance (MR) fingerprinting (MRF) data for quantitative characterization of focal cortical dysplasia (FCD). Materials We included 119 subjects, 33 patients with epilepsy and histopathologically confirmed FCD, 60 age‐ gender‐matched healthy controls (HCs), 26 disease (DCs). Subjects underwent whole‐brain Tesla MRF acquisition, the reconstruction which generated T1 T2...
To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as model pathogen. Compared with oil adjuvant, killed NDV LMS+ induced significantly higher helper T cell type 1 response, shown by levels of interleukin-2, interferon-γ, proliferation, delayed-type hypersensitivity responses, without sacrificing...
Both humoral and cell-mediated immune responses are important to protect animals from initial acute viral infection establishment of chronic infection. Adjuvants for DNA vaccines can influence the balance between immunities. In this study, a vaccine encoding hemagglutinin–neuraminidase fusion genes Newcastle disease virus (NDV) incorporated with chicken interferon(provax-chIFN-γ) cDNA as molecular adjuvant levamisole (LMS) chemical was tested its efficacy in protection against NDV lethal...
Various approaches have been used to improve the efficacy of DNA vaccination, including incorporation molecular adjuvants. Because CD40 ligand-CD40 interaction plays a major role in initiating immune responses, we sought develop adjuvant targeting this interaction.We immunized mice with foot-and-mouth disease virus vaccine, pcD-VP1, together CD40-expressing plasmid, pcD-CD40. We found that pcD-CD40 induced anti-CD40 antibodies, which temporally correlated augmented production anti-VP1...
Fungal effectors play important roles in host–pathogen interactions. Botryosphaeria dothidea is an ascomycetous fungus that responsible for the diseases of hundreds woody plant species, including apple ring rot, which seriously affects apples worldwide. However, little known about B. dothidea. In this study, we analyzed genome and predicted 320 candidate effector genes, 124 were successfully amplified cloned. We investigated effects these genes on cell death Nicotiana benthamiana while using...
Previous studies have shown that the gut microbiota and its metabolites are associated with success of organ transplantation. However, specific changes in lung transplant patients remain unclear. Hence, this study aimed to elucidate interplay between microbiota, metabolome, transplantation outcomes. Using 16S metagenomics sequencing untargeted metabolic profiling, we conducted a comprehensive analysis microbial alterations recipients relative non-transplant group. Our findings revealed...
Abstract Objective To evaluate the efficacy and safety of intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE). Methods PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Biomedical Literature Database (CBM), VIP Science Technology Journal Full-text (VP-CSJFD), Wanfang database were searched by computer from establishment to January 17, 2024. Relevant randomized controlled articles IPHC as observational...
Type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is a T cell-mediated autoimmune disease characterized by lymphocytic infiltration of pancreatic islets with subsequent destruction the insulin-producing cells. The regulatory (Treg) cell has been suggested to play an important role controlling inflammatory T1D. We previously demonstrated that induction antigen-specific Treg cells vivo co-immunization DNA vaccine its encoded protein can effectively inhibit diseases. To...
We sought to improve focal cortical dysplasia (FCD) lesion detection by combining MR fingerprinting (MRF) with voxel-based morphometric MRI analysis. acquired high-resolution MRF and T1w MPRAGE data from 29 patients 47 age-and-gender-matched healthy controls. FCD probability maps were generated using the analysis program (MAP18). T1 T2 values in white matter significantly higher true-positive clusters than false-positive clusters. Using normalized T1, T2, cluster size as input, an SVM model...
Focal cortical dysplasia (FCD) is a common pathology in medically intractable focal epilepsy and often difficult to detect by visual inspection of conventional MRI. We developed framework for automatic FCD detection using surface-based processing MRI MR fingerprinting data. Thirty-six patients with 48 healthy controls were included. Improved vertex-wise cluster-wise performance was seen when MRF FLAIR features added T1w A second-stage classifier showed efficacy reduce false-positive...