A5019876087- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Peripheral Nerve Disorders
- Phytochemistry and Biological Activities
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Myasthenia Gravis and Thymoma
- Muscle activation and electromyography studies
- Nerve injury and regeneration
- Cervical and Thoracic Myelopathy
- Natural product bioactivities and synthesis
- Flame retardant materials and properties
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Traditional Chinese Medicine Analysis
- Prion Diseases and Protein Misfolding
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Cancer-related gene regulation
- Neurological Disease Mechanisms and Treatments
- Ion channel regulation and function
- TiO2 Photocatalysis and Solar Cells
Wenzhou Medical University
2025
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Hubei University of Medicine
2024
Wuhan Prevention and Treatment Center for Occupational Diseases
2024
National Yunlin University of Science and Technology
2023-2024
Sun Yat-sen University
2021-2023
Lanzhou University
2021-2023
National Nuclear Center of the Republic of Kazakhstan
2023
Northern Jiangsu People's Hospital
2020-2023
Catalytic conversion of hydrogen peroxide (H2O2) to more toxic hydroxyl radicals (•OH) is a good choice for sterilization and anti-infection, but endogenous H2O2 insufficient achieve satisfactory efficacy. Despite great efforts, designing developing antimicrobial materials that specifically effectively self-supply at the wound site remain as tremendous challenges. Here, we report pH-responsive copper peroxide-loaded dressing made from hydroxide gelatin sponge then reacted with H2O2. In vitro...
Abstract Unusual rainfall is the primary cause of failure tailing dams, and overtopping most representative model dam failure. The upstream was selected as research object to study whole process breach extension dam-failure mechanism under full-scale condition. results showed that significant size grading phenomenon in front, middle, end pond obvious due flow separation effect, its average particle diameter D50. At different moments rainfall, height infiltration line at positions body...
To investigate the genetic contribution of ANXA11, a gene associated with amyotrophic lateral sclerosis (ALS), in Chinese ALS patients and without cognitive dementia.Sequencing all coding exons ANXA11 intron-exon boundaries 18 familial (FALS), 353 unrelated sporadic (SALS), 12 ALS-frontotemporal lobar dementia (ALS-FTD). The transcripts peripheral blood generated from splicing mutation were examined by reverse transcriptase PCR.We identified 6 nonsynonymous heterozygous mutations (5 novel 1...
Abstract This study aims to observe the nutritional status of Chinese patients with amyotrophic lateral sclerosis (ALS), further investigating its effect on disease progression. One hundred consecutive newly diagnosed ALS and fifty controls were included. Weight body composition measured by bioelectrical impedance analysis at baseline follow-ups. The revised functional rating scale (ALSFRS-R) was used calculate rate Patients had a significantly lower BMI than controls, while no significant...
This study aimed to evaluate the long-term health outcomes and quality of life (HRQoL) associated with untreated pelvic floor dysfunction (PFD) in women, identify key factors contributing symptom severity. A cohort 1,651 women aged 18 years older PFD were recruited between June 2018 August 2023. Data on sociodemographic, lifestyle factors, clinical history collected via questionnaires assessments. The Pelvic Floor Distress Inventory (PFDI-20) Short Form-12 (SF-12) used assess severity HRQoL....
Abstract Background Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) were two major motor neuron diseases with similar symptoms poor outcomes. This study aimed to identify potential biomarkers in disease monitoring differential diagnosis of adult SMA patients sporadic ALS patients. Methods was a pilot ten consecutively enrolled during hospitalization. Serum cerebrospinal fluid (CSF) samples collected for assessment neurofilament light (NFL) phosphorylated heavy chain...
Objective: To evaluate serum creatine kinase (CK) levels of amyotrophic lateral sclerosis (ALS) patients and to explore the relationship between CK clinical characteristics survival prognosis ALS patients. Methods: We analyzed 185 who underwent long-term follow-up. The features including sex, age, disease duration, site onset, body mass index, creatinine spontaneous electromyographic activity were by univariate analysis multiple linear regression. Kaplan–Meier Cox proportional hazards models...
Layer 2/3 (L2/3) excitatory neurons in the neocortex make major contributions to corticocortical connections and therefore function integrate information across cortical areas hemispheres. Recent evidence suggests that L2/3 can have different properties. Sparse from previous studies L2 located at border between L1 (referred as marginal neurons, L2MNs), a morphology distinct typical pyramidal neuron. However, whether membrane properties input/output of L2MNs are those is unknown. Here we...
Objective To examine the frequency and clinical features of excessive daytime sleepiness (EDS) its association with cognitive behavioural impairments in patients amyotrophic lateral sclerosis (ALS). Methods We conducted a cross-sectional investigation to explore EDS group 121 Chinese ALS compared age-matched sex-matched healthy subjects. was diagnosed using Epworth Sleepiness Scale (ESS). Other characteristics including sleep quality, REM behaviour disorder (RBD), restless legs syndrome...
Detailed morphological features of the peripheral nerves could improve diagnostic sensitivity in some polyneuropathies. In this study we aimed to establish multiple-site, cross-sectional area (CSA) reference values for upper extremities a healthy Chinese population.One hundred eleven subjects, 15 70 years age, were prospectively recruited. CSA at predetermined sites median, ulnar, radial nerves, and brachial plexus was measured bilaterally. Ten consecutive studied along median/ulnar...
Abstract Objectives The aim of this study was to assess and compare the diagnostic utility a new criteria for amyotrophic lateral sclerosis (ALS), abbreviated as ‘Gold Coast Criteria’, with revised El Escorial (rEEC) Awaji criteria. Methods Clinical electrophysiological data 1185 patients from January 2014 December 2019 in Peking Union Medical College Hospital ALS database were reviewed. sensitivity Gold compared that possible rEEC (defined by proportion categorized definite, probable, or...