A5052531064- Wound Healing and Treatments
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Electrospun Nanofibers in Biomedical Applications
- Ginseng Biological Effects and Applications
- Gastric Cancer Management and Outcomes
- Polymer Surface Interaction Studies
- Estrogen and related hormone effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Ginger and Zingiberaceae research
- Metastasis and carcinoma case studies
- Skin Protection and Aging
- Advanced biosensing and bioanalysis techniques
- Inflammatory mediators and NSAID effects
- Polysaccharides and Plant Cell Walls
- Supramolecular Self-Assembly in Materials
- Cancer Cells and Metastasis
- Metabolism and Genetic Disorders
- Phagocytosis and Immune Regulation
- Gastrointestinal Tumor Research and Treatment
- Biocrusts and Microbial Ecology
Lanzhou University
2020-2024
Lanzhou University Second Hospital
2020-2024
Gansu Provincial Maternal and Child Health Hospital
2021-2023
Chinese People's Liberation Army
2021
117th Hospital of People's Liberation Army
2021
Lanzhou Army General Hospital
2013
Catalytic conversion of hydrogen peroxide (H2O2) to more toxic hydroxyl radicals (•OH) is a good choice for sterilization and anti-infection, but endogenous H2O2 insufficient achieve satisfactory efficacy. Despite great efforts, designing developing antimicrobial materials that specifically effectively self-supply at the wound site remain as tremendous challenges. Here, we report pH-responsive copper peroxide-loaded dressing made from hydroxide gelatin sponge then reacted with H2O2. In vitro...
Abstract The traditional treatment for bacterial infections is the use of antibiotics, but overuse antibiotics can lead to formation multidrug‐resistant bacteria, and eventually biofilms, which resist attack host immune system penetration in biofilms. Although biofilm‐targeted stimulus‐responsive antibiotic delivery nanocarriers are available, drugs that be delivered extremely limited. Therefore, an amphiphilic supramolecule Arg‐CD‐AcMH constructed via host–guest interactions between...
Lactate has long been considered an intermediate by-product of glucose metabolism. However, in recent years, accumulating evidence reveals that lactate unique biological activities. In previous studies, signaling was shown to inhibit inflammation. Furthermore, vitro experiments have can promote the transformation pro-inflammatory macrophages into anti-inflammatory macrophages. no vivo studies whether alleviate RAW 264.7 were stimulated by LPS induce M1 phenotype, and cultured with low high...
Hypoxia-induced epithelial-to-mesenchymal transition (EMT) could facilitate tumor progression. TIPE2, the necrosis factor-α (TNF-α)-induced protein 8-like 2 (also known as TNFAIP8L2), is a member of TNF-α-induced 8 (TNFAIP8, TIPE) family and has been involved in development progression several tumors. However, effects TIPE2 on EMT process glioma cells underlying mechanisms these have not previously reported. In our study, we assessed roles response to hypoxia. Our results indicated that...
In the present study, anti-inflammatory effect of Lycium barbarum polysaccharide (LBP) and possible molecular mechanism thereof were examined, so as to perceive pharmacological action LBP. With acute peritonitis in mice inflammatory model, protective LBP on was evaluated by recording behavioral scores, studying pathological damage intestine liver, detecting levels cytokines. Additionally, establishing an lipopolysaccharide (LPS)-induced RAW264.7 macrophage cell phenotype culture supernatant...
Anastomotic leakage is a serious complication following gastrointestinal surgery and one of the leading causes patient mortality. Despite significant clinical economic burden, there are currently no reliable treatment options to improve healing intestinal anastomosis subsequently prevent anastomotic leakage. Recently, development regenerative medicine has shown promise for improving healing. Recent studies have illustrated that stem cell-derived secretome can enhance tissue regeneration...
This study aimed to examine the role of Zizyphus jujuba cv. Muzao polysaccharides (ZJPs) in protecting intestinal barrier function and survival septic mice. The sepsis mouse model was generated through cecal ligation puncture (CLP) observe effect ZJPs on context sepsis. We observed clinical symptoms time mice evaluated serum inflammatory cytokines, pathological changes permeability. Moreover, tight junction (TJ) proteins apoptosis-associated tissue were examined. Finally, TLR4/NF-κB...
This work aims to prepare ion/thrombin hybrid microflowers and thrombin/MOF by means of different biomineralization methods improve the instability, bioavailability poor storage stability thrombin.
The objective of this study is to elucidate the influence MCU on clinical pathological features GC patients, investigate function and mechanism mitochondrial calcium uptake transporter in initiation progression GC, explore its impact metabolic pathways biosynthesis mitochondria. ultimate goal identify novel targets strategies for management patients.
Despite the risk of lymph node metastasis (LNM), indications endoscopic submucosal dissection (ESD) has expanded to undifferentiated type (UD-type) early gastric cancer (EGC). There is debate as whether resection can be used. This study was conducted evaluate factors for LNM in cancer, implications indication ESD so providing evidence proper clinical management UD-type EGC.We retrospectively analyzed 203 patients with EGC who underwent gastrectomy primary adenocarcinoma between 2012 and...
Gansu province is a high incidence area of gastric cancer,and the mortality caused by cancer ranks first in China.A safe and effective treatment key point research.In recent years,tumor-targeted therapy has become new research direction along with gradually increased understanding molecular biology mechanism.Several studies have shown that expression cyclooxygenase (COX)-2 plays an important role occurrence development malignant tumor.Celecoxib,a non-steroidal anti-inflammatory drug,is novel...