A5100408233- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Protein purification and stability
- Lattice Boltzmann Simulation Studies
- Advanced Data Storage Technologies
- Nasal Surgery and Airway Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lung Cancer Diagnosis and Treatment
- Apelin-related biomedical research
- Hemostasis and retained surgical items
- Air Quality and Health Impacts
- Effects of Radiation Exposure
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Pancreatitis Pathology and Treatment
- Drug Solubulity and Delivery Systems
- Advanced Proteomics Techniques and Applications
- Noise Effects and Management
- Surgical Simulation and Training
- Oral health in cancer treatment
- Curcumin's Biomedical Applications
- Polymer Surface Interaction Studies
- Ferroptosis and cancer prognosis
- Advanced Drug Delivery Systems
- Lung Cancer Treatments and Mutations
Institute of Automation
2024
Chinese Academy of Sciences
2024
Lanzhou University
2021-2023
Tianjin Institute of Pharmaceutical Research (China)
2021-2022
Tianjin Medical University
2022
Lanzhou University Second Hospital
2021-2022
Southern Medical University
2022
Nanfang Hospital
2022
Nanjing General Hospital of Nanjing Military Command
2020
Huazhong University of Science and Technology
2008
Serum analysis represents an extreme challenge due to the dynamic range of proteins interest, and high structural complexity constituent proteins. In serum, quantities peptides interest from those considered "high abundance", present at 2-70% by mass total protein, "low 10(-12) M or less. This analytical target molecules is outside realm available technologies for proteomic analysis. Therefore, in this study, we have developed a workflow toward addressing these samples through application...
Radiation-induced intestinal injury is characterized by barrier impairment. However, the therapeutic effects of probiotics for epithelial repair in a mouse model radiation-induced remain unclear. Previously, we isolated strain Bacteroides fragilis from feces healthy infant and named it as B. ZY-312 ( ). In this study, showed that can ameliorate mice, manifested decreased weight loss, length shortening, cell (IEC) shedding. Moreover, found promoted IEC proliferation, stem regeneration, mucus...
The purpose of this study is to design a flower-shaped lactose loaded curcumin solid lipid nanoparticles dry powder inhaler and characterize it improve the solubility dissolution rate in lung. Curcumin (Cur-SLNs) were prepared by solvent evaporation method, then they micronized freeze-drying technology. Finally, Cur-SLN micropowder obtained was mixed with (FL) at ratio 2 : 1 passed through 200-mesh sieve obtain Cur-SLN-FL powder. Tween-80 selected as surfactant inhibit aggregation drug...
Nanonization strategies have been used to enhance the oral availability of numerous drugs that are poorly soluble in water. Exploring a facile nanonization strategy with highly practical potential is an attractive focus. Here, we report novel nanoaggregation for constructing drug nanoparticles pH-dependent solubility by utilizing acid-base neutralization aqueous solution, thus facilitating exploration delivery general applicability. We demonstrate hydrophobic itraconazole dissolved acid...
This work aims to prepare ion/thrombin hybrid microflowers and thrombin/MOF by means of different biomineralization methods improve the instability, bioavailability poor storage stability thrombin.
NPM1 plays an important role in the occurrence and development of leukemia various solid tumors. This study aimed to investigate expression gastric cancer (GC) adjacent normal tissues, relationship between clinicopathological characteristics GC patients, explore impact on diagnosis prognosis GC. We used tissue microarray immunohistochemical analysis examine level tissues analyzed expression, factors, prognosis. Prognostic values mRNA were also investigated using online database. qRT-PCR was...
Tumor-associated p53 mutations induce activities different from wild-type p53, thus causing loss of the protein's tumor inhibition function. The cells carrying have more aggressive characteristics related to invasion, metastasis, proliferation, and cell survival. By comparing gene expression profiles mutant (mutp53) mutp53 silenced cohorts, we found that FOS-related antigen-1 (FRA-1), which is encoded by FOSL1, a potential effector mutp53-mediated metastasis. We demonstrate FRA-1, gatekeeper...
The development of spray drying technology has been widely used for and preservation food products. Though infant milk powder iron fortification is necessary infants children, accompanied by some limitations that reduce its quality oxidation Fe2+ into Fe3+, causing sensory problems even a decrease in absorption, which does not meet the normal requirements child body development. To overcome this adverse effect to improve bioavailability iron, method was simulate production process codrying...
Localizing the bronchoscope in real time is essential for ensuring intervention quality. However, most existing methods struggle to balance between speed and generalization. To address these challenges, we present BronchoTrack, an innovative real-time framework accurate branch-level localization, encompassing lumen detection, tracking, airway association.To achieve performance, employ a benchmark lightweight detector efficient detection. We are first introduce multi-object tracking...
Bronchoscopy plays a significant role in the early diagnosis and treatment of lung diseases. This process demands physicians to maneuver flexible endoscope for reaching distal lesions, particularly requiring substantial expertise when examining airways upper lobe. With development artificial intelligence robotics, reinforcement learning (RL) method has been applied manipulation interventional surgical robots. However, unlike human who utilize multimodal information, most current RL methods...
Accurate bronchoscope localization is essential for pulmonary interventions, by providing six degrees of freedom (DOF) in airway navigation. However, the robustness current vision-based methods often compromised clinical practice, and they struggle to perform real-time generalize across cases unseen during training. To overcome these challenges, we propose a novel Probabilistic Airway Navigation System (PANS), leveraging Monte-Carlo method with pose hypotheses likelihoods achieve robust...
Vision-based surgical navigation has received increasing attention due to its non-invasive, cost-effective, and flexible advantages. In particular, a critical element of the vision-based system is tracking instruments. Compared with 2D instrument methods, 3D broader value in clinical practice, but also more challenging weak texture, occlusion, lack Computer-Aided Design (CAD) models for registration. To solve these challenges, we propose SurgTrack, two-stage method CAD-free robust real-world...
Accurate and complete segmentation of airways in chest CT images is essential for the quantitative assessment lung diseases facilitation pulmonary interventional procedures. Although deep learning has led to significant advancements medical image segmentation, maintaining airway continuity remains particularly challenging. This difficulty arises primarily from small dispersed nature structures, as well class imbalance scans. To address these challenges, we designed a Multi-scale Nested...
Although occupational exposure to radiation and organic solvents has been proven increase the chance of developing thyroid disease, one leading endocrine disorders, much less is known about potential risk factor vibration exposure. Thus, this study aimed examine relationships between radiation, vibration, disease thyroid-stimulating hormone (TSH) levels by utilizing data sets from Project ELEFANT, which comprises 124,286 participants Tianjin, China. We reviewed medical records, including...
Abstract Background The third-generation of EGFR-TKI Osimertinib has become an important treatment option for patients with EGFR-mutant advanced NSCLC. In recent years, more and studies have begun to pay attention the ability miRNAs in exosomes secreted by tumor cells transmit resistance information. mechanisms exosomal involved need be studied. Methods We constructed Osimertinib-resistant cell line H1975-OR, collected from drug-resistant strain sensitive strain, extracted respective RNA...
<title>Abstract</title> Background We have previously shown that P2X7R/NLRP3-mediated signaling pathway plays an important role in CP chronic inflammation and fibrosis. Inspired by the traditional Chinese medicine(TCM) theory “Chaihu Guizhi Decoctio(CGD)for treatment of Sudden pain heart or abdomen". Targeting central sensitization(CS) may explain Chaihu Decoction (CGD) on CP-induced pain. Methods Fifty male SD rats were randomly equally divided into two groups based table random numbers:...