A5027182776- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Neurological Disorders and Treatments
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Autophagy in Disease and Therapy
- Genetic Mapping and Diversity in Plants and Animals
- Endometriosis Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic and phenotypic traits in livestock
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Retinal Imaging and Analysis
- Viral Infections and Vectors
- Ocular Surface and Contact Lens
- Reproductive System and Pregnancy
- Mitochondrial Function and Pathology
- Retinopathy of Prematurity Studies
- Retinal and Macular Surgery
- Endometrial and Cervical Cancer Treatments
- Pregnancy-related medical research
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Peking Union Medical College Hospital
2010-2025
University of Chinese Academy of Sciences
2019-2024
Eye & ENT Hospital of Fudan University
2013-2024
Fudan University
2012-2024
Institute of Microbiology
2021-2024
Chinese Academy of Sciences
2012-2024
Shanghai Medical College of Fudan University
2018-2024
Zhongshan Hospital of Xiamen University
2023
Hyogo Medical University
2001-2021
Background To examine histomorphometrically the parapapillary region in human eyes. Methodology/Principal Findings The histomorphometric study included 65 globes (axial length:21–37 mm). On anterior-posterior histological sections, we measured distance Bruch's membrane end (BME)-optic nerve margin (“Gamma zone”), BME-retinal pigment epithelium (RPE) (“Beta BME-beginning of non-occluded choriocapillaris, and photoreceptor layer. “Delta zone” was defined as part gamma zone which blood vessels...
Highlights•Single-cell and spatial data reveal hierarchical microenvironment in endometriomas•Ectopic endometrial stromal cells retain menstrual cycle gene expression patterns•Distinct ovarian (OSCs) links to fibrosis inflammation lesions•WNT5A signaling mediates interactions between ectopic OSCsSummaryEndometriosis is a chronic condition with limited therapeutic options. The molecular aberrations promoting attachment the local sustaining lesion growth have been unclear, prohibiting...
Purpose.: To examine the morphologic features of parapapillary atrophy by using enhanced depth imaging optical coherence tomography (EDI-OCT) and color fundus photographs. Methods.: The clinical observational comparative study included 80 normal eyes 46 subjects patients with primary open-angle glaucoma. Both groups did not vary significantly in axial length (P = 0.62) refractive error 0.30). Color photographs cross-sectional B-scan images obtained EDI-OCT were examined. On images, we...
To determine whether acute intraocular pressure (IOP) elevation alters dynamin-related protein 1 (Drp1) as well a selective inhibitor of Drp1, mdivi-1, can block apoptotic cell death and subsequently increase retinal ganglion (RGC) survival in ischemic mouse retina.C57BL/6 mice received injections mdivi-1 (50 mg/kg) or vehicle, then transient ischemia was induced by IOP elevation. RGC measured after FluoroGold labeling. Drp1 glial fibrillary acidic (GFAP) expression distribution were...
MicroRNAs (miRNAs) are short noncoding RNA that participate in posttranscriptional gene regulation. However, little is understood about the roles of miRNAs Alzheimer's disease (AD). In this study, we used next-generation sequencing on extracted from serum samples 20 AD patients and controls, yielding a total 72 with significantly changed expression levels. Among these candidates, selected 9 most significant alteration disease, validated their levels using RT-qPCR analysis 45 40 control...
Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records.Demographic information and comorbidities adult who were observed for at least 5 years with initial observation dates between 1988 1998, records Partners Healthcare System tools National Center Biomedical Computing "Informatics Integrating Biology Bedside" (i2b2).A predictive model was constructed a set 9,349 (843 cases, 8,506 controls) Bayesian...
Abstract Glaucoma is a leading cause of irreversible blindness and characterized by progressive damage retinal ganglion cells (RGCs). Growing evidences have linked impaired mitophagy with neurodegenerative diseases, while the E3 ubiquitin ligase parkin may play key role. However, pathophysiological relationship between glaucoma remains largely unknown. Using chronic hypertensive rats induced translimbal laser photocoagulation, we show here that protein level its downstream optineurin...
To investigate the difference between two-dimensionally measured disc diameters (DDs) based on fundus images and three-dimensionally DDs enhanced depth imaging optical coherence tomography (EDI-OCT).The were EDI-OCT of optic nerve heads near-infrared reflectance in 90 normal eyes subjects. Disc rotation around sagittal axis was defined as angle maximal DD vertical axis. horizontal axes cosine divided by images.Mean 14.4 ± 9.3°, 23.0 21.3°, 4.7 6.6°. Horizontal, vertical, minimal,...
Abstract Background Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) were two major motor neuron diseases with similar symptoms poor outcomes. This study aimed to identify potential biomarkers in disease monitoring differential diagnosis of adult SMA patients sporadic ALS patients. Methods was a pilot ten consecutively enrolled during hospitalization. Serum cerebrospinal fluid (CSF) samples collected for assessment neurofilament light (NFL) phosphorylated heavy chain...
Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed impaired mitochondrial dynamics occurs early in diseases. Optic Atrophy Type 1 (OPA1), fusion protein, has recently been suggested to be mitophagic factor. Our previous studies found glaucomatous damage may ameliorated by an increase OPA1. In this study, we explored the mechanism involved OPA1 mediated neuroprotection and its relationship with parkin...
Purpose.: To investigate how OPA1 expression and distribution are altered by increased nitric oxide (NO) whether aminoguanidine, a relative selective NO synthase (NOS)-2 inhibitor, can restore subsequently increase retinal ganglion cell (RGC) survival in ocular hypertensive rats. Methods.: Elevated intraocular pressure was induced unilaterally translimbal laser photocoagulation of the trabecular meshwork Sprague-Dawley Aminoguanidine (100 mg/kg) administered intraperitoneal injection for 3...
To examine the morphology of optic nerve head in patients with unilateral peripapillary intrachoroidal cavitations (PICCs).The hospital-based observational study included PICCs. Tomographic images parapapillary fundus were taken by enhanced depth imaging mode optical coherent tomography. The ocular biometric parameters compared between affected eyes and contralateral unaffected eyes.The population consisted 30 a mean age 42.7 ± 13.8 years (range: 22-72 years), axial length 26.7 2.4 mm...
Aspergillus fumigatus is one of the most common pathogenic fungi, which results in high morbidity and mortality immunocompromised patients. Amphotericin B (AMB) used as core drug for treatment triazole-resistant A. fumigatus. Following usage amphotericin drugs, number B-resistant isolates showed an increasing trend over years, but mechanism mutations associated with sensitivity are not fully understood. In this study, we performed a k-mer-based genome-wide association study (GWAS) 98 from...
Purpose.: Transgenic Col1a1r/r mice develop elevated intraocular pressure (IOP) with an open angle and progressive optic nerve axon loss. The present study was undertaken to evaluate aqueous outflow facility its age dependence in these mice. Methods.: Homozygous B6;129S4-Col1a1 tm1Jae corresponding wild-type Col1a1 +/+ from 12 56 weeks of were anesthetized, IOP measured a microneedle. Outflow determined by two-level, constant-pressure infusion method. Type I collagen, subunit α1 assessed...
Purpose To compare various biometric parameters between fellow eyes of acute primary angle closure (glaucoma) [APAC(G)] and chronic [CPAC(G)]. Methods Ultrasound biomicroscopy examinations were performed on 47 patients with unilateral APAC(G) 41 asymmetric CPAC(G) before laser peripheral iridotomy pilocarpine treatment. Anterior chamber depth width (ACD ACW), lens vault (LV), iris curvature (IC), root distance (IRD), trabecular-ciliary process (TCPD), iris-ciliary (ICPD), (TCA), other...
Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading irreversible blindness. Growing evidence has linked impaired mitochondrial quality control with RGCs degeneration, while parkin, an E3 ubiquitin ligase, proved be protective promotes mitophagy against excitotoxicity. The purpose of this study was explore whether a small molecule S3 could modulate parkin-mediated therapeutic potential for RGCs. results showed...
Pangenomes are replacing single reference genomes to capture all variants within a species or clade, but their analysis predominantly leverages graph-based methods that require multiple high-quality and computationally intensive multiple-genome alignments. K-mer decomposition is an alternative pangenomes. However, how directly use k-mers for the population genetic analyses unknown. Here, we developed novel strategy uses of k-mer count in genome analyses. To test effectivity this method,...
BACKGROUND--Inflammation associated with neutrophil infiltration is a commonly observed feature of children cystic fibrosis. Production the major chemotactic cytokine interleukin 8 (IL-8) potentially great importance in pathology Concentrations IL-8 both sputum and bronchoalveolar lavage fluid have been found to be higher fibrosis than controls. The induced response numbers receptors on peripheral neutrophils obtained from compared control group children. METHODS--Cells were isolated 18...
<h3>Background</h3> To investigate the association between position of central retinal vessel trunk (CRVT) in optic nerve head and pattern remaining visual field thickness fibre layer (RNFL) end-stage glaucoma. <h3>Methods</h3> The clinical observational study included patients with glaucoma a island (CI-group) or temporal remnant (TI-group). CRVT exit on lamina cribrosa was evaluated disc photographs. RNFL measured by optical coherence tomography. <h3>Results</h3> 21 22 remnant. Both groups...