A5100700676- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Tuberous Sclerosis Complex Research
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Oral health in cancer treatment
- Muscle and Compartmental Disorders
- Craniofacial Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Corneal Surgery and Treatments
- Cancer Cells and Metastasis
- Augmented Reality Applications
- Urinary Bladder and Prostate Research
- Chronic Kidney Disease and Diabetes
- Sexual function and dysfunction studies
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
Shanghai University of Sport
2024
General Administration of Sport of China
2024
National Clinical Research Center for Digestive Diseases
2024
Air Force Medical University
2024
Affiliated Hospital of Qingdao University
2019-2023
Qingdao University
2019-2023
Peking Union Medical College Hospital
2017-2021
Xiangya Hospital Central South University
2021
Central South University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2020
Bladder cancer (BC) and Renal cell carcinoma(RCC) are the two most frequent genitourinary cancers in China. In this study, a comprehensive liquid chromatography-mass spectrometry (LC-MS) based method, which utilizes both plasma metabolomics lipidomics platform, has been carried out to discriminate global profiles of 64 patients with BC, 74 RCC, 141 healthy controls. Apparent separation was observed between (BC RCC) samples The area under receiving operator characteristic curve (AUC) 0.985...
Renal cell carcinoma (RCC) is the second most lethal urinary cancer. RCC frequently asymptomatic and it already metastatic at diagnosis. There an urgent necessity for specific biomarkers selection diagnostic prognostic purposes. In present study, we applied liquid chromatography-mass spectrometry (LC-MS) based metabolomics to analyze urine samples of 100 RCC, 34 benign kidney tumors 129 healthy controls. Differential metabolites were analyzed investigate if could differentiate from non-RCC....
Clear cell renal carcinoma (ccRCC) is one of the most common types malignant adult kidney cancer, and its incidence mortality are not optimistic. It well known that tumor-related protein markers play an important role in cancer detection, prognosis prediction, or treatment selection, such as carcinoembryonic antigen (CEA), programmed death 1 (PD-1), ligand (PD-L1), cytotoxic T lymphocyte 4 (CTLA-4), so a comprehensive analysis was performed this study to explore prognostic value expression...
To explore the safety and efficacy of selective 5-serotonin norepinephrine reuptake inhibitor duloxetine hydrochloride alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in treatment pain disorder chronic prostatitis/chronic pelvic syndrome (CP/CPPS). In all, 150 patients were enrolled 126 completed study (41 group, 41 sertraline 44 group). This was an open randomized 6-month study. CP/CPPS who met diagnostic criteria into 3 groups. The group received 4...
Abstract Purpose To evaluate the efficacy and safety of everolimus sirolimus in patients with tuberous sclerosis complex-associated angiomyolipomas (TSC-AML). Materials methods We performed a multi-institutional retrospective study TSC-AML treated oral 10 mg or 2 per day for at least 3 months. Angiomyolipoma volume was estimated using orthogonal measurements by MRI CT. Adverse events (AEs) were assessed according to National Cancer Institute Common Terminology Criteria Events. All analyses...
Plasma metabolomics and lipidomics have been commonly used for biomarker discovery. Studies in white Japanese populations suggested that gender age can affect circulating plasma metabolite profiles; however, the characteristics Chinese population has not surveyed. In our study, we applied liquid chromatography-mass spectrometry-based approach to analyze metabolome lipidome a cohort of 534 healthy adults (aging from 15 79). Fatty-acid metabolism was found be gender- age-dependent Chinese,...
This study investigated the prognostic value of preoperative albumin alkaline phosphatase ratio (AAPR) in patients with muscle-invasive bladder cancer after radical cystectomy.We performed a retrospective, single-center cohort among who underwent cystectomy and urinary diversion at Department Urology Surgery Affiliated Hospital Qingdao University from 2007 to 2015. Cox proportional hazards regression was used evaluate relationship between AAPR outcomes which include OS CSS RFS. Survival...
Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore correlations between glycolysis with immune activity clinical traits bladder urothelial carcinoma (BLCA).Our study obtained scores for each BLCA samples from TCGA by single-sample gene set enrichment analysis (ssGSEA) algorithm, based on glycolytic set. The relationship prognosis, characteristics, function were investigated subsequently.We found that enhanced associated poor prognosis...
Recent studies have reported that examining the fragmentation profiles (FP) of plasma cell-free DNA (cfDNA) further improves clinical sensitivity tumor detection. We hypothesized considering differences FP urinary cfDNA would increase genitourinary (GU) cancer detection.177 patients with GU and 94 individuals without tumors were enrolled in discovery cohort. An independent validation dataset comprising 30 66 was also collected. constructed an ensemble classifier, GUIDER, to detect localize...
Several disease-causing genes have been implicated in Carney complex (CNC), including PRKAR1A, PDE8B(Phosphodiesterase 8B),and PDE11A (Phosphodiesterase 11A). The purpose of this study was to describe the clinical features CNC a Chinese patient and identify potential pathogenic mutations.Genomic DNA extracted from peripheral venous blood obtained one family Shandong province. Subsequently, targeted region sequencing (TRS) Sanger validation were performed validate likely mutations.Genetic...
Patients with renal cell carcinoma are often troubled by metastases, but masseter muscle metastases particularly rare.We reported a 76-year-old male who did not show any recurrence and metastasis after the nephrectomy until 5 years later. The metastatic mass was found protrusion of area. Computed tomography ultrasonography indicated hypervascular mass, pathology confirmed carcinoma. Complete metastasectomy performed preserval facial function appearance. No local or distant in follow-up.Our...
The wounds caused by war, accidents, and diseases require timely effective treatment. Polysaccharides, as natural macromolecules, have good biocompatibility unique functions, are excellent substrates for constructing new wound dressings. Short-chain chitosan (SCS) has water solubility and, importantly, retains a large number of active amino groups. We first introduce double bonds to SCS. This derivative can be entangled with sodium alginate (SA) through electrostatic interaction. flowing sol...
Abstract Background Inflammatory response biomarkers have been studied as promising prognostic factors in renal cell carcinoma, but few studies focused on papillary carcinoma (PRCC). This study was performed to evaluate the value of preoperative neutrophil-to-lymphocyte ratio (NLR) PRCC patients. Methods In total, 122 postoperative patients selected from 366 non-clear were enrolled our institution between 2012 and 2020. The optimal cutoff NLR assessed by receiver operating characteristic...
Abstract Objective To explore the clinical value of Gleason score upgrading (GSU)prediction model after radical prostatectomy (RP) based on a Bayesian network. Methods The data 356 patients who underwent prostate biopsy and RP in our hospital from January 2018 to May 2021 were retrospectively analysed. Fourteen risk factors,including age, body mass index (BMI), total prostate-specific antigen (tPSA), volume, density (PSAD), number proportion positive cores, PI-RADS score, stage postoperative...