A5053319938- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Air Quality and Health Impacts
- Cancer Immunotherapy and Biomarkers
- Occupational and environmental lung diseases
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Renal and related cancers
- Acute Myeloid Leukemia Research
- Mycorrhizal Fungi and Plant Interactions
- Immune Cell Function and Interaction
- Microbial Metabolic Engineering and Bioproduction
- 3D Shape Modeling and Analysis
- Plant Pathogens and Fungal Diseases
- Pneumothorax, Barotrauma, Emphysema
- Pediatric Urology and Nephrology Studies
- Polysaccharides and Plant Cell Walls
- Renal cell carcinoma treatment
- Biofuel production and bioconversion
- Infectious Disease Case Reports and Treatments
- Hematopoietic Stem Cell Transplantation
China Academy of Chinese Medical Sciences
2025
Chinese Academy of Sciences
2016-2024
Shanghai Center For Bioinformation Technology
2020-2024
Beijing Institute of Genomics
2016-2024
Nankai University
2023
Anhui University of Science and Technology
2021-2022
Huazhong University of Science and Technology
2022
Hunan University of Science and Technology
2021
Jiangsu Cancer Hospital
2021
Jiangsu Province Hospital
2021
Abstract Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial-temporal diversity and influence on tumor evolution the immune microenvironment remain largely unclear. We apply computational methods to analyze ecDNA from whole-genome sequencing data of 595 urothelial carcinoma (UC) patients. demonstrate that drives clonal through structural rearrangements during malignant transformation recurrence UC. This supports model wherein tumors evolve via...
Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy subsequent upper tract urothelial carcinoma (UTUC).East Asian populations, who have high prevalence of UTUC, an unusual genome-wide AA-induced mutational pattern (COSMIC signature 22).Integrating analysis with clinicopathological information may demonstrate great potential ranking this UTUC subtype.Methods: We performed whole-genome sequencing (WGS) on 90...
Immune checkpoint inhibitors (ICIs) have revolutionized the management of locally advanced or metastatic urothelial carcinoma. Strikingly, compared to carcinoma bladder (UCB), upper tract (UTUC) has a higher response rate ICIs. The stratification patients most likely benefit from ICI therapy remains major clinical challenge.
Cold stimulation of Bailinggu’s mycelia is the main factor that triggers primordia initiation for successful production fruiting bodies under commercial cultivation. Yet, molecular-level mechanisms involved in response to cold are still unclear. Here, we performed comparative transcriptomic analysis using RNA-Seq technology better understand gene expression regulation during different temporal stages Bailinggu. A total 21,558 Bailinggu unigenes were de novo assembled and annotated from four...
Abstract Background Coal dust particles (CDP), an inevitable by-product of coal mining for the environment, mainly causes workers’ pneumoconiosis (CWP). Long-term exposure to leads a complex alternation biological processes during regeneration and repair in healing lung. However, cellular complete molecular changes associated with pulmonary homeostasis caused by respiratory remain unclear. Methods This study investigated toxicity respirable-sized CDP mice using unbiased single-cell RNA...
Recent advancements in diffusion techniques have propelled image and video generation to unprece- dented levels of quality, significantly accelerating the deployment application generative AI. However, 3D shape technology has so far lagged behind, constrained by limitations data scale, complexity process- ing, insufficient exploration advanced tech- niques domain. Current approaches face substantial challenges terms output generalization capa- bility, alignment with input conditions. We...
Abstract Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial-temporal diversity and influence on tumor evolution the immune microenvironment remain largely unclear. Here, we apply computational methods to detect reconstruct ecDNA from whole-genome sequencing data 595 patients prospectively recruited into Chinese Urothelial Carcinoma Genome Atlas (CUGA) study. We demonstrate that contributes clonal through structural rearrangements copy number...
Gallbladder cancer (GBC) is a highly aggressive biliary epithelial malignancy. The median survival time of GBC patients was less than 1 year. Tumor invasion and metastasis are the major cause high mortality patients. However, molecular mechanisms involved in metastases still unclear.We performed 10X genomics single-cell RNA sequencing (scRNA-seq) on liver tissue to evaluate characteristics microenvironment.In this study, 8 cell types, total 7,788 cells, including T B malignant fibroblasts,...
At present, the extent and clinical relevance of epigenetic differences between upper tract urothelial carcinoma (UTUC) bladder (UCB) remain largely unknown. Here, we conducted a study to describe global DNA methylation landscape UTUC UCB address prognostic value subtype responses methyltransferase inhibitor SGI-110 in (UC).
Recent studies have reported that examining the fragmentation profiles (FP) of plasma cell-free DNA (cfDNA) further improves clinical sensitivity tumor detection. We hypothesized considering differences FP urinary cfDNA would increase genitourinary (GU) cancer detection.177 patients with GU and 94 individuals without tumors were enrolled in discovery cohort. An independent validation dataset comprising 30 66 was also collected. constructed an ensemble classifier, GUIDER, to detect localize...
Significance Statement Vitamin C levels decline in patients with various kidney diseases, but the role of vitamin as an epigenetic regulator initiation and progression diseases has not been characterized. Using Gulo −/− mice, which, like humans, entirely depend on dietary C, we applied single-cell RNA sequencing, whole genome bisulfite methylated immunoprecipitation sequencing to create first comprehensive renal cell type–specific transcriptional DNA/RNA methylation profiles. deficiency...
Tumor staging of upper tract urothelial carcinomas (UTUCs) is relatively difficult to assert accurately before surgery. Here, we used copy number (CN) signatures as a tool explore their clinical significance molecular stratification in UTUC. CN were extracted by non-negative matrix factorization from the whole-genome sequencing (WGS) data 90 Chinese UTUC primary tumor samples. A validation cohort ( n = 56) and urinary cell-free DNA (cfDNA) cancer patients 94) matched tumors also examined....
Hydroa vacciniforme lymphoproliferative disorder (HVLPD) is a rare disease related to Epstein-Barr virus (EBV), mainly in children, and an EBV-associated cutaneous T natural killer (NK) cell disorder. The some patients may progress systemic or NK-cell lymphoma. To summarize the characteristics of HVLPD Chinese paediatric examine risk factors indicating poor prognosis. We performed retrospective analysis with from Department Dermatology, Beijing Children's Hospital. Based on diagnosis,...