A5004791791- Plant Water Relations and Carbon Dynamics
- Irrigation Practices and Water Management
- Greenhouse Technology and Climate Control
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Drug-Induced Hepatotoxicity and Protection
- Antibiotic Resistance in Bacteria
- Renal and related cancers
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Antibiotics Pharmacokinetics and Efficacy
- Bladder and Urothelial Cancer Treatments
- Phytochemistry and biological activity of medicinal plants
- Cancer Immunotherapy and Biomarkers
- Respiratory and Cough-Related Research
- Acute Kidney Injury Research
- Hydrology and Watershed Management Studies
- Chromatography in Natural Products
- Chemotherapy-induced organ toxicity mitigation
- Atherosclerosis and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
Capital Institute of Pediatrics
2022-2025
Shanghai Center For Bioinformation Technology
2020-2023
North China University of Water Resources and Electric Power
2022-2023
Beijing Institute of Genomics
2021-2022
Chinese Academy of Sciences
2021-2022
University of Chinese Academy of Sciences
2020-2022
Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known epitranscriptional regulatory mechanism affecting central biological processes, but its function in human cellular senescence remains uninvestigated. Here, we found that levels of both m6A and the methyltransferase METTL3 were reduced prematurely senescent mesenchymal stem cell (hMSC) models progeroid syndromes. Transcriptional profiling modifications further identified MIS12, for which hMSCs METTL3-deficient hMSCs....
Crop evapotranspiration estimation is a key parameter for achieving functional irrigation systems. However, ET difficult to directly measure, so an ideal solution was develop simulation model obtain ET. There are many ways calculate ET, most of which use models based on the Penman–Monteith equation, but they often inaccurate when applied greenhouse crop evapotranspiration. The machine learning predict has gradually increased, research into their application crops relatively rare. We used...
Immune checkpoint inhibitors (ICIs) have revolutionized the management of locally advanced or metastatic urothelial carcinoma. Strikingly, compared to carcinoma bladder (UCB), upper tract (UTUC) has a higher response rate ICIs. The stratification patients most likely benefit from ICI therapy remains major clinical challenge.
It is particularly important to know crop evapotranspiration (ET) in order create an effective irrigation program that avoids wasting water. There are many ways calculate ET, most of which use models based on the Penman–Monteith equation, but they often inaccurate when applied greenhouse evapotranspiration. The machine learning predict ET has gradually increased, research into their application for crops relatively rare. We used experimental data three years (2019–2021) model effects eight...
We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory severity. To further explore potential mechanism, a murine model is established high-dose bacteria. stimulates granular neutrophils (G0), subsequently transforming them into phagocytic (G1). HiAlc causes...
Abstract The adenoids and tonsils are important immune organs of the nasopharynx that often become hypertrophic in childhood because recurrent pathogen infection. However, differences microenvironment adenoid hypertrophy (AH) tonsil (TH) unclear. Here, we show epidemiological characteristics peripheral blood cell indices 1209 pediatric patients (1–15 years old) diagnosed with AH, find AH is accompanied by TH characterized specific changes types. Single-cell RNA sequencing analysis 12 paired...
In recent years, several drugs have been withdrawn from use by regulatory bodies owing to hepatotoxicity; therefore, studies on drug-induced liver injury (DILI) are being actively pursued. Most evaluating DILI rats or mice as animal models determine drug toxicity; however, the toxicity of a can vary between mice. These inconsistencies in
Introduction The increased prevalence of non-alcoholic fatty liver disease (NAFLD) and sarcopenia among the elderly are facing a significant challenge to world’s health systems. Our study aims identify coexpressed genes in NAFLD patients. Methods We downloaded transcriptome data tissue from patients, as well muscle tissues GEO database order investigate shared transcriptional regulation mechanisms between these two diseases. Then, focusing on that were frequently expressed diseases, together...
The improvement of the simulation accuracy crop models in different greenhouse environments would be better applied to automation management cultivation. Tomatoes under drip irrigation a were taken as research object, and cumulative evaporation capacity (Ep) 20 cm standard dish was basis for irrigation. Three treatments set up experiment: high water treatment without mulch (NM-0.9 Ep), with (M-0.9 low (M-0.5 Ep). AquaCrop DSSAT used simulate canopy coverage, soil content, biomass, yield...
Osteoporosis is a disease that impacts the elderly. Low estrogen related to changes in DNA methylation and consequent alterations gene expression, leading new direction research pathophysiology of osteoporosis. We constructed an Ovariectomized (OVX) mouse model our study, models had osteoporosis based on phenotype levels mouse's bone. Furthermore, level OVX mice was significantly changed compared SHAM mice. Therefore, we performed genome-level analysis using transcriptome Whole Genome...
High-alcohol-producing K. pneumoniae (HiAlc Kpn) causes nonalcoholic fatty liver disease (NAFLD) by producing excess endogenous alcohol in the gut of patients with NAFLD, using glucose as main carbon source. The role response HiAlc Kpn to environmental stresses such antibiotics remains unclear. In this study, we found that could enhance resistance polymyxins. First, inhibited expression crp and promoted increase capsular polysaccharide (CPS), which drug Kpn. Second, maintained high ATP...
Staphylococcus aureus is an opportunistic pathogen that shows a unique ability to quickly respond variety of antibiotics. The Crp/Fnr family transcriptional regulator ArcR controls expression arginine deiminase pathway genes arcABDC, which enable the utilization as energy source for cell growth under anaerobic conditions. However, shares low overall similarity with other proteins, suggesting they differ in response environmental stress. In this study, MIC and survival assays were performed...
Herb-induced liver injury (HILI) has become a great concern worldwide due to the widespread usage of herbal products. Among these products is Dictamni Cortex (DC), well-known Traditional Chinese Medicine (TCM), widely used treat chronic dermatosis. drawn increasing attention because its hepatotoxicity caused by hepatotoxic component, dictamnine. However, potential mechanism dictamnine remains unclear. Therefore, this study aimed use multi-omics approach (transcriptomic, metabolomic, and...
Significance Statement Vitamin C levels decline in patients with various kidney diseases, but the role of vitamin as an epigenetic regulator initiation and progression diseases has not been characterized. Using Gulo −/− mice, which, like humans, entirely depend on dietary C, we applied single-cell RNA sequencing, whole genome bisulfite methylated immunoprecipitation sequencing to create first comprehensive renal cell type–specific transcriptional DNA/RNA methylation profiles. deficiency...
Background and Purpose Tibetan medicine is one of the oldest traditional systems in world. Taking Ruyi Zhenbao tablet (RYZB) as an example, which a widely used classic oral medicine, this article discusses pharmacokinetics single administration long-term treatment, analyzed its metabolic properties tissue distribution vivo. Experimental approach After administration, blood samples were collected before different time points after groups rats. In study treatment effects, from animals each...
Mastering root distribution is essential for optimizing the zone environment and improving water use efficiency, especially crops cultivated in greenhouses. Here, we set up two irrigation amount levels based on measurements of cumulative 20 cm pan evaporation (Ep) (i.e., K0.9: 0.9 Ep; K0.5: 0.5 Ep), three ventilation modes through opening greenhouse vents at different locations (TR: open roof only; TRS: both south vents; TS: only) to reveal effects mode tomato. Six treatments were designed...