A5074935874- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Digestive system and related health
- Respiratory viral infections research
- RNA modifications and cancer
- Diet and metabolism studies
- Immune Response and Inflammation
- Hydrocarbon exploration and reservoir analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Microbial infections and disease research
- Ferroptosis and cancer prognosis
- Hydraulic Fracturing and Reservoir Analysis
Capital Institute of Pediatrics
2020-2025
China Medical University
2023
We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory severity. To further explore potential mechanism, a murine model is established high-dose bacteria. stimulates granular neutrophils (G0), subsequently transforming them into phagocytic (G1). HiAlc causes...
The objective of this study was to identify a kind prognostic signature based on oxidative stress- and anoikis-related genes (OARGs) for predicting the prognosis immune landscape NSCLC. Initially, We identified 47 differentially expressed OARGs that primarily regulate stress epithelial cell infiltration through PI3K-Akt pathway. Subsequently, 10 related determined two potential clusters. A cluster associated with shorter survival level, lower infiltration, higher stemness index tumor...
Abstract Background: With the development of sequencing technologies, it has been found that there are microbes similar to those in upper respiratory tract present healthy human lower (LRT), including lungs and bronchus. Thus, study LRT microbiome evaluate relationship between this allergic diseases children, we enrolled 68 children who visited department underwent bronchoscopy from January 2018 December affiliated hospital Capital Institute Pediatrics. Methods: Using total IgE (TIgE)...
Abstract Mycoplasma pneumoniae is one of the leading causes community-acquired pneumonia in children and adolescents. Because wide application macrolides clinical treatment, macrolide-resistant M. strains have become increasingly common worldwide. However, molecular mechanisms underlying drug resistance are poorly understood. In present work, we analyzed whole proteomes macrolide-sensitive using a tandem mass tag-labeling quantitative proteomic technique, Data available via ProteomeXchange...
Abstract Klebsiella pneumoniae, a major pathogen leading to severe pneumonia, causes clinical complications in nosocomial and community-acquired infections. We have previously reported that high alcohol-producing K. pneumoniae (HiAlc Kpn) the gut microbiome are strongly associated with nonalcoholic fatty liver disease (NAFLD) owing excess endogenous alcohol production. In present study, we discovered Kpn isolated from sputum bronchoalveolar fluid (BALF) of patients chronic obstructive...