A5101465565- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Diabetes Treatment and Management
- Systemic Lupus Erythematosus Research
- Biochemical Analysis and Sensing Techniques
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Cholesterol and Lipid Metabolism
- Family and Patient Care in Intensive Care Units
- Garlic and Onion Studies
- Cardiovascular Disease and Adiposity
- Cardiac tumors and thrombi
- Berberine and alkaloids research
- Estrogen and related hormone effects
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Renal Diseases and Glomerulopathies
- CAR-T cell therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and preeclampsia studies
Qingdao University
2011-2022
Affiliated Hospital of Qingdao University
2017-2022
Nanchang University
2022
Third Hospital of Nanchang
2022
Third Affiliated Hospital of Nanchang University
2022
Jiangyin People's Hospital
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2012
Peking Union Medical College Hospital
2010-2012
Visceral fat is considered the genuine and harmful white adipose tissue (WAT) that associated to development of metabolic disorders, cardiovascular disease, cancer. Here, we present a new concept turn visceral into beneficial energy consumption depot, which for improvement dysfunctions in obese mice. We show low temperature-dependent browning caused decreased weight, total body mass index, despite increased food intake. In high-fat diet-fed mice, temperature exposure improved fat, global...
This review aims to analyse the efficacy of dietary supplements in reducing plasma cholesterol levels. Focusing on evidence from meta-analyses randomised controlled clinical trials, with an emphasis potential mechanisms action as supported by human, animal, and cell studies. Certain including phytosterols, berberine, viscous soluble fibres, garlic supplements, soy protein, specific probiotic strains, certain polyphenol extracts could significantly reduce total low-density lipoprotein (LDL)...
To determine whether steroidogenic enzyme expression is associated with the steroid secretory pattern of subclinical Cushing's syndrome (SCS) by investigating mRNA and protein CYP17 CYP11B1 in SCS adenomas, normal adrenal cortices (NA), non-functional adenomas (NFA) cortisol-producing (CPA).Total RNA were extracted from 20 CPA, six SCS, 15 NFA, eight NA. Real-time quantitative polymerase chain reaction (PCR) western blotting analysis performed to different tissues. The adrenocortical tumors...
Aims. To examine the potential differences between multiple daily injection (MDI) regimens based on new long-acting insulin analogues (glargine or detemir) plus prandial aspart and continuous subcutaneous infusion (CSII) in patients with poorly controlled type 2 diabetes. Methods. Patients (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">119</mml:mn></mml:math>) diabetes of a duration exceeding five years were...
The present study aimed to investigate the expression of aldosterone synthase (CYP11B2), adrenocorticotropic hormone receptor (ACTH-R) and their regulating transcription factors in adrenal incidentalomas (AIs) from normotensive hypertensive patients distinguish subclinical or atypical primary aldosteronism (PA) AIs. Total RNA was extracted 8 normal cortices (NAs), 46 AIs, 15 aldosterone-producing adenomas (APAs) 6 idiopathic hyperaldosteronisms (IHAs). Real-time quantitative polymerase chain...
Several disease-causing genes have been implicated in Carney complex (CNC), including PRKAR1A, PDE8B(Phosphodiesterase 8B),and PDE11A (Phosphodiesterase 11A). The purpose of this study was to describe the clinical features CNC a Chinese patient and identify potential pathogenic mutations.Genomic DNA extracted from peripheral venous blood obtained one family Shandong province. Subsequently, targeted region sequencing (TRS) Sanger validation were performed validate likely mutations.Genetic...
Objective To detect mRNA and protein expression of steroidogenic factor-1 ( SF-1 ) DAX-1 in human adrenocortical tumors normal adrenal cortex,and to investigate the effect on steroidogenesis development tumors.Methods Total RNA was extracted from angiotensin Ⅱ unresponsive aldoterone-producing adenomas A -U-APA,n =12 ),angiotensin responsive AⅡ -R-APA,n =5 ),cortisol-producing CPA,n =10 ),adrenal nonfunctional NFA,n ),aldosterone-producing carcinoma APC,n =2 cortex NAC,n =8).To analyze gene...
Epigenetic regulation affects the development and differentiation of iNKT cells. Our previous study found that number cells in thymus RA mice was reduced ratio subsets unbalanced, but related mechanism remains unclear. We adopted an adoptive infusion iNKT2 with specific phenotypes functions to used α-Galcer treatment group as control. The results showed that: 1. Adoptive decreased proportion iNKT1 iNKT17 mice, increased subsets. 2.After cells, expression PLZF DP T T-bet mice. 3.Adoptive...
The present study aimed to compare the therapeutic effect of sodium/glucose cotransporter 2 (SGLT2) inhibitor and benazepril on diabetic nephropathy (DN) rats provide a potential novel agent for clinical treatment DN. DN model was established rats. Animals were dosed orally with SGLT2 daily 4 weeks. pathological state renal tissues evaluated using hematoxylin eosin, Masson periodic acid-Schiff staining. change in morphology observed through transmission electron microscopy. Western blotting...