A5013345797- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Chromatography in Natural Products
- Selenium in Biological Systems
- Flavonoids in Medical Research
- Mechanisms of cancer metastasis
- GDF15 and Related Biomarkers
- Natural product bioactivities and synthesis
- Oral Health Pathology and Treatment
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- Macrophage Migration Inhibitory Factor
- Tumors and Oncological Cases
- Peanut Plant Research Studies
- Developmental Biology and Gene Regulation
- Ferroptosis and cancer prognosis
- Medical and Biological Ozone Research
- Seaweed-derived Bioactive Compounds
- Cancer Mechanisms and Therapy
- Essential Oils and Antimicrobial Activity
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Berberine and alkaloids research
- Polysaccharides Composition and Applications
- Fungal Biology and Applications
Peking University
2024-2025
Henan Academy of Sciences
2025
Molecular Oncology (United States)
2024-2025
State Key Laboratory of Molecular Oncology
2024-2025
Harbin University of Commerce
2013-2024
Peking University International Hospital
2024
University Health Network
2015-2024
University of Toronto
2012-2024
Association for Language Learning
2024
Nanjing Medical University
2021-2023
Forkheadbox protein 3 (FOXP3), initially identified as a key transcription factor for regulatory T cells (Treg cells), was also expressed in many tumors including pancreatic ductal adenocarcinoma (PDAC). However, its role PDAC progression remains elusive. In this study, we utilized 120 tissues after radical resection to detect cancer-FOXP3 and Treg by immunohistochemistry evaluated clinical pathological features of these patients. Cancer-FOXP3 positively correlated with accumulation tumor...
Liver cancer is the sixth most commonly diagnosed and fourth common cause of death. The purpose this work to find new diagnostic biomarkers or prognostic explore biological functions related prognosis liver cancer.
In this study, ultrasound-assisted extraction of flavonoid from Crinum asiaticum was studied through response surface methodology (RSM) to gain the best process and enhance rate flavonoid. following RSM experiment, we selected corresponding data every factor as center point single-factor experiments, then experimental subjected multiple regression analysis. According statistical analysis results, results were consistent with polynomial model, determination coefficient (R2) 0.9769. The...
Autophagy allows recycling of cellular components and may facilitate cell survival after chemotherapy. Pantoprazole inhibits proton pumps is reported to inhibit autophagy. Here we evaluate the effects pantoprazole modify cytotoxicity anticancer drug docetaxel, underlying mechanisms. Effects docetaxel±pantoprazole were studied against wild-type autophagy-deficient PC3 cells four human xenografts. on autophagy evaluated by quantifying LC3-I, LC3-II p62 proteins in western blots, fluorescent...
Tertiary lymphoid structures (TLSs) are formed in long-term chronic inflammation, promoting the local recruitment of lymphocytes, antigen presentation and regulation immune response, correlated with a better prognosis for cancer patients. Although studies have been conducted to explore methods that accelerate establishment TLSs, related research head neck squamous cell carcinoma (HNSCC) is still lacking. In this study, we analysed data from The Cancer Genome Atlas performed...
Background Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of BTLA promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating potential as a prognostic predictive biomarker for response. Methods We analyzed gene expression data from public datasets (The Cancer Genome Atlas (TCGA), Gene Expression...
Approximately 40% ERα-positive breast cancer patients suffer from therapeutic resistance to tamoxifen. Although reduced ERα level is the major cause of tamoxifen resistance, underlying mechanisms remain elusive. Here, we report that FRMD8 raises at both transcriptional and post-translational layers. deficiency in MMTV-Cre + ; Frmd8 fl/fl PyMT mice accelerates mammary tumor growth loss luminal phenotype, confers resistance. Single-cell RNA profiling reveals decreases proportion...
Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, is associated with an increased risk of Acute Myocardial Infarction (AMI). The genetic mechanisms underlying this link are not well understood. We downloaded IBD AMI-related microarray datasets from the NCBI Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified analyzed using enrichment analysis Weighted Co-expression Network Analysis (WGCNA). Machine learning...
Abstract Objective The metastatic ability of breast cancer cells with chemoresistant properties is higher when compared to that their parental wild‐type cells. Expression AnnexinA2 (Anxa2), a 36‐kDa calcium‐dependent phospholipid binding protein, increased in tumours and has been found be associated the phenotype drug resistance metastasis. Materials Methods Results In present study, we up‐regulation Anxa2 correlates enhanced migration invasion MCF ‐7 both vitro vivo . Western blot analysis...
Background Exosomal miRNA had been proved as the promising biomarkers for multiple cancers including epithelial ovarian cancer (EOC). This study aimed to validate diagnostic accuracy of exosomal miR-320d, miR-4479, and miR-6763-5p EOC. Materials methods Exosomes isolated from plasma by ultracentrifugation were verified using TEM, qNano western blot. MiRNAs sequencing was used screen out differential miRNAs selected candidates, which further RT-qPCR in 168 healthy donors 161 primary EOC...
In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with chlorosulfonic acid pyridine method. The inhibitory effect of application MTT assay before after chemical modification on proliferation hepatocellular carcinoma HepG-2 cells in vitro studied. sargassum DS 0.803. modified has certain cells, its inhibition growth improved compared original SFPs....
The transmembrane sensor protein VirA activates VirG in response to high levels of acetosyringone (AS). In order respond low AS, requires the periplasmic sugar-binding ChvE and monosaccharides released from plant wound sites. To better understand how senses these inducers, C58 virA gene was randomly mutagenized, 14 mutants defective vir induction containing mutations which mapped input domain were isolated. Six had single missense mutatiions three widely separated areas domain. Eight or near...
One novel bisabolane-derived sesquiterpenoid retrobisabolane A (1), featuring a methyl group location at the C-4 position instead of C-3 in bisabolanes, and known ester-substituted eremophilane-type cryptosphaerolide (2), along with three indole alkaloids (3-5) were discovered from fermented cultures deep-sea-derived fungus Retroconis fusiformis MCCC 3A00792. The planar structure new compound 1 was determined by extensive analysis NMR HRESIMS spectra. relative absolute configurations...
This study investigated the nature and mechanism of juglone-induced apoptosis in human breast cancer cell line MCF-7. The inhibitory effect juglone on MCF-7 growth was evaluated by dimethylthiazol tetrazolium assay. Morphological apoptotic changes were characterized using an inverted microscope, Hoechst 33258 fluorescence staining, Giemsa staining. rate apoptosis, intracellular levels reactive oxygen species (ROS), mitochondrial membrane potential detected flow cytometry. Intracellular...
This study describes a new alternative combination preservative containing caprylyl glycol, phenethyl alcohol and glyceryl caprylate investigates the effects of particle size emulsion droplet on anti-microbial activity said blend in formulation.The ingredients were determined via MIC, MBC, MFC fractional inhibitory concentration (FIC) determination using broth microdilution method. The inhibited micro-organism contamination oil-in-water emulsion, its performance was affected by droplet, as...
Cisplatin is a chemotherapeutant widely used in treating solid tumors, with the common side effect of acute kidney injury (AKI). Developing effective useful agent for preventing or cisplatin-induced AKI great importance. In this study, we investigate protective vaccarin, chemical entity flavonoid glycoside, against AKI. Cisplatin-treated C57BL/6J mice and human kidney-2 (HK-2) cells were as model The levels blood urea nitrogen (BUN) creatine (Cr) periodic acid-Schiff staining (PAS) scores...
Residue dissipation and risk assessment of difenoconazole its metabolite difenoconazole-alcohol during tea growing, processing, brewing was first investigated by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The limits quantification for both were 0.001 mg/kg in fresh leaves tea, 0.0002 mg/L infusion. In field trials, the half-lives 1.77 days. After spraying, residues increased then gradually dissipated like difenoconazole. 14 days, rates reached 99%. When...
To investigate FAM20A gene variants and histological features of amelogenesis imperfecta to further explore the functional impact these variants.
Abstract Breast cancer (BC) is one of the most common types among women worldwide. Lycorine ( Lycoris radiata ), a small molecule derived from traditional Chinese herb Amaryllidaceae plants, has appeared potential effect on inhibiting growth cells and inducing apoptosis in various with minor side effects. To discuss therapeutic effects molecular mechanisms lycorine BC established by lycorine‐treated S180 tumour‐bearing mice vivo. Furthermore, both mitotic microtubule assembly dynamics genes...
Approximately 40% ERα-positive breast cancer patients suffer from therapeutic resistance to tamoxifen. Although reduced ERα level is the major cause of tamoxifen resistance, underlying mechanisms remain elusive. Here, we report that FRMD8 raises at both transcriptional and post-translational layers. deficiency in MMTV-Cre + ; Frmd8 fl/fl PyMT mice accelerates mammary tumor growth loss luminal phenotype, confers resistance. Single-cell RNA profiling reveals decreases proportion...