A5101845060- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Neurogenesis and neuroplasticity mechanisms
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Healthcare and Venom Research
- Nerve injury and regeneration
- Medicinal Plant Pharmacodynamics Research
- Reproductive System and Pregnancy
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Natural product bioactivities and synthesis
- Cytomegalovirus and herpesvirus research
- Axon Guidance and Neuronal Signaling
- Circular RNAs in diseases
- interferon and immune responses
- Medical Research and Treatments
- 14-3-3 protein interactions
- Plant-based Medicinal Research
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
Capital Medical University
2015-2024
Beijing Tian Tan Hospital
2012-2023
Beijing Tongren Hospital
2013
Capital University
2004-2011
Bu Shen Yi Sui capsule (BSYS) is a traditional Chinese medicine prescription that has shown antineuroinflammatory and neuroprotective effects in treating multiple sclerosis (MS) its animal model of experimental autoimmune encephalomyelitis (EAE). Microglia play an important role neuroinflammation. The M1 phenotype microglia involved the proinflammatory process disease, while M2 plays anti-inflammatory role. Promoting polarization to MS/EAE promising therapeutic strategy. This study aimed at...
T helper (Th) 17 and regulatory (Treg) cells play a critical role in the pathogenesis of multiple sclerosis (MS) disease. Bu Shen Yi Sui Capsule (BSYSC), traditional Chinese medicine formula, has been used clinically for treatment MS patients China. To evaluate neuroprotective effects underlying mechanisms BSYSC on MS, experimental autoimmune encephalomyelitis (EAE) model C57BL/6 mice was induced with myelin oligodendrocyte glycoprotein (MOG) 35–55. Th17 Treg related cytokines were detected...
In neuromyelitis optica (NMO), one of the underlying pathogenic mechanisms is formation antigen-antibody complexes which can trigger an inflammatory response by inducing infiltration neutrophils in lesions. Epithelial neutrophil-activating peptide 78 (ENA 78), known as Chemokine (C-X-C motif) ligand 5 (CXCL5), belongs to ELR-CXCL family. It recruits and activates neutrophils. The aim this study was evaluate ENA 78, IL-1β TNF-α plasma levels multiple sclerosis (MS) (NMO) patients. were...
Background/Aims. Multiple sclerosis (MS) is an autoimmune disorder that affects the central nervous system (CNS) primarily hallmarked by neuroinflammation and demyelination. The activation of astrocytes exerts double-edged sword effects, which perform integral function in demyelination remyelination. In this research, we examined therapeutic effects Bu Shen Yi Sui capsule (BSYS), a traditional Chinese medicine prescription, cuprizone- (CPZ-) triggered model MS (CPZ mice). This research...
Abstract The aim of this work is to investigate and analyze the main factors that influence quality life (QOL) multiple sclerosis (MS) patients. QOL (Multiple Sclerosis Impact Scale), disability (Expanded Disability Status fatigue (Modified Fatigue Scale) depression (Beck Depression Inventory) were assessed in 100 MS Correlation analysis shows positively correlated with status, depression, i.e. more severe disability, worse QOL. Multiple linear regression indicated Expanded Scale grade have...
Graphical Abstract Our results show that fingolimod is a potential therapeutic approach to prevent EAE-induced visual impairment. Moreover, we the observed neuro-ophthalmological protective effects of were dependent on hampering hyper-gliosis in retina and optic nerve.
Abstract Background Multiple sclerosis (MS) as an autoimmune disorder is a common disease occurring in central nervous system (CNS) and the remyelination plays pivotal role alleviating neurological impairment MS. Catalpol, effective component extracted from Chinese herb Radix Rehmanniae , which has been proved protective cerebral diseases. Methods To determine effects mechanisms of Catalpol on MS, mice with experimental encephalomyelitis (EAE) were induced by myelin oligodendrocyte...
Background: A prominent pathological feature of neuromyelitis optica spectrum disorders (NMOSD) is markedly greater eosinophilic infiltration than that seen in other demyelinating diseases, like multiple sclerosis (MS). Eosinophils express the chemokine receptor CCR3, which activated by eotaxins (CCL11/eotaxin-1, CCL24/eotaxin-2, CCL26/eotaxin-3) and CCL13 (monocyte chemoattractant protein-4). Moreover, part set activates CCR2. The present study aimed to evaluate plasma levels (CCL11, CCL24,...
Axonal damage is recognized as an important pathological feature in the chronic progressive neurological disorder multiple sclerosis (MS). Promoting axonal regeneration a critical strategy for treatment of MS. Our clinical and experimental studies have shown that Bu Shen Yi Sui formula (BSYS) promotes MS autoimmune encephalomyelitis (EAE), animal model MS, but exact mechanism has not been thoroughly elucidated to date. In this study, we investigated effects BSYS its two decomposed...
The endogenous neurotransmitter, noradrenaline, exerts anti-inflammatory and neuroprotective effects in vivo vitro. Reduced noradrenaline levels results increased inflammation neuronal damage. primary source of the central nervous system is tyrosine hydroxylase (TH)‑positive neurons, located locus coeruleus (LC). TH rate‑limiting enzyme for synthesis; therefore, regulation protein expression intrinsic activity represents means controlling synthesis noradrenaline. Catalpol an iridoid...
Axon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage multiple sclerosis (MS). Bu Shen Yi Sui Capsule (BSYSC) is an effective Chinese formula utilized to treat MS clinical setting noted for potent neuroprotective effects. In this study, we focus on effects BSYSC promoting underlying mechanisms mice with experimental autoimmune encephalomyelitis (EAE), animal model MS.The EAE mouse was...
Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system. Bu-shen-yi-sui capsule (BSYSC) could significantly reduce relapse rate, prevent progression MS, and enhance remyelination following neurological injury in experimental autoimmune encephalomyelitis (EAE), an established model MS; however, mechanism underlying effect BSYSC on has not been well elucidated. This study showed that exosomes carrying biological information are involved...
A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly called Erhuang Formula) in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis. However, its effect on axonal injury during early sclerosis remains unclear. In this study, a MOG35-55-immunized C57BL/6 mouse model experimental autoimmune encephalomyelitis was intragastrically administered Capsule. The results showed that effectively improved symptoms and...
Discovery of specific antibodies against astrocytic water channel aquaporin-4 (AQP4), which is produced by plasma cells, in the serum neuromyelitis optica (NMO) confirmed pathogenic role B cells NMO. C-X-C motif ligand 13 (CXCL13) and B-cell-activating factor (BAFF) are two crucial factors for antibody production. Relevant studies have focused on acute phase However, CXCL13 BAFF levels during remission, remain to be elucidated.To evaluate NMO multiple sclerosis (MS) patients remission...
To evaluate the effect of Tanreqing injection on axon myelin in mouse brain experimental autoimmune encephalomyelitis (EAE).An EAE model was established by oligodendrocyte glycoprotein (MOG)35-55 immunization C57BL/6 mice. Mice were randomly divided into following groups: normal, model, prednisone acetate (PA) (6 mg/kg), high dose (5.14 mL/kg), low (2.57 mL/kg). On day immunization, both groups treated intraperitoneal injection, with PA group intragastrical perfusion after T cell response,...
Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem that important for myelin repair regeneration. In the present study, capsule effectively improved clinical symptoms neurological function scores, reduced mortality promoted recovery functions mice with experimental autoimmune encephalomyelitis. The mechanism...