A5100695625- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- Advancements in Semiconductor Devices and Circuit Design
- Virus-based gene therapy research
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Retinal Diseases and Treatments
- Single-cell and spatial transcriptomics
- BRCA gene mutations in cancer
- Advanced Multi-Objective Optimization Algorithms
- Retinal Imaging and Analysis
- Berberine and alkaloids research
- Renal cell carcinoma treatment
First Affiliated Hospital Zhejiang University
2013-2025
Beijing Jishuitan Hospital
2024
Peking University
2024
Xinxiang Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2023
Guangdong Provincial People's Hospital
2015-2023
Beijing Hospital of Traditional Chinese Medicine
2021-2022
Capital Medical University
2021-2022
Southern Medical University
2012-2022
Guangdong Academy of Medical Sciences
2022
Abstract Background Consolidative allogeneic hematopoietic stem cell transplantation is a controversial option for patients with relapsed/refractory acute lymphoblastic leukemia after chimeric antigen receptor T (CAR-T) therapy. We performed multicenter retrospective study to assess whether can benefit from haploidentical CAR-T Methods A total of 122 therapy were enrolled, including 67 without subsequent (non-transplant group) and 55 (transplant group). Long-term outcome was assessed, as its...
Renal cell carcinoma (RCC) is characterized by a variety of subtypes, each defined unique genetic and morphological features. This study utilizes single-cell RNA sequencing to explore the molecular heterogeneity RCC. A highly proliferative subset, termed as "Prol," was discovered within RCC tumors, its increased presence linked poorer patient outcomes. An artificial intelligence network, encompassing traditional regression, machine learning, deep learning algorithms, employed develop Prol...
// Jin Meng 1 , Ping Li Qing Zhang 2,3 Zhangru Yang and Shen Fu 1,2,3 Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, China 2 Oncology Center, Fudan Cancer Center (FUSCC), Shanghai, 3 Dept, Proton Heavy Ion (SPHIC), Correspondence: Fu, email: Keywords : radiosensitivity, glioma, glioblastoma multiforme, gene signature, EMT Received May 1, 2014 Accepted June 9, Published 10, Abstract A 31-gene signature derived by integrating four...
Abstract Background Accurate predictors of survival for patients with advanced gastric cancer treated neoadjuvant chemotherapy are currently lacking. In this study, we aimed to evaluate the prognostic significance neutrophil-lymphocyte ratio (NLR) in stage III-IV who received chemotherapy. Methods We enrolled 46 study. The NLR was divided into two groups: high (>2.5) and low (≤2.5). Univariate analysis on progression-free (PFS) overall survival(OS) performed using Kaplan-Meier log-rank...
ObjectiveThis study is designed to identify genes and pathways that could promote metastasis the bowel in high-grade serous ovarian cancer (OC) evaluate their associations with clinical outcomes.MethodsWe performed RNA sequencing of OC primary tumors (PTs) corresponding metastases (n = 21 discovery set; n 18 replication set). Differentially expressed (DEGs) were those at least 2-fold higher (BMets) than PTs 30% patients (P < .05) no increased expression paired benign tissue validated...
To investigate the expression and associations of putative stem cell markers with survival in patients locally advanced gastric cancer (GC) receiving neoadjuvant chemotherapy. This study included 180 GC who received chemotherapy subsequent radical gastrectomy between June 2010 December 2014. Surgical paraffin samples from enrolled were collected. Tissue microarrays used to detect patterns 10 markers; immunohistochemistry was evaluate CD133 SOX2 adjacent tissues. The prognostic values these...
The immune system plays a complementary role in the cytotoxic activity of radiotherapy. Here, we examined changes cell subsets after heavy ion therapy for prostate cancer. lymphocyte counts were compared with acute radiotherapy-related toxicity, defined according to Common Terminology Criteria Adverse Events, and short-term local efficacy, based on prostate-specific antigen concentrations. Confirmed cancer patients who had not received previous radiotherapy administered carbon (CIR) daily...
Aurora kinase B (AURKB) is a type of functional with primary functions participating in cell mitosis, which has been identified to be involved the occurrence and development malignant tumors strongly. However, it still remains controversial respect relationship between phosphorylation level AURKB its function. In our initial research, there was no significant difference relative content protein drug-resistant breast cancer cells wild-type cells; however, significantly higher than that cells....
Chemotherapy resistance represents a formidable obstacle in advanced or metastatic colorectal cancer (CRC) patients. It is reported that ATPase copper transporting alpha (ATP7A) plays an important role chemotherapy CRC. Here, we identified ATP7A as potentially key gene of OXA The patients with higher expression tended to have platinum drug resistance. While the lower by siRNA knockdown resulted enhancement sensitivity and increased OXA-induced apoptosis. Further, demonstrated novel safe...
Summary Chimeric antigen receptor T (CAR‐T) cell therapy is highly effective in inducing complete remission haematological malignancies. Severe cytokine release syndrome (CRS) the most significant and life‐threatening adverse effect of this therapy. This multi‐centre study was conducted at six hospitals China. The training cohort included 87 patients with multiple myeloma (MM), an external validation 59 MM another 68 acute lymphoblastic leukaemia (ALL) or non‐Hodgkin lymphoma (NHL). levels...
7028 Background: r/r B-ALL was reported as the most-threatening disease because of low free survival even treatment with allogeneic hematopoietic stem cell transplantation. For overcoming conventional therapies limitation, autologous CD19CAR-T performed in our clinical trials to induce remission patients disease. 30 (from 7 centers, China) volunteers were treated by CD19 CAR-T. Methods: 5 juveniles and 25 adults ALL received targeted CAR-T, doses between 1.03 × 10 6 CAR-T cells/kg 10.09...
Despite high remission rates following chimeric antigen receptor T cell (CAR-T) therapy in B-cell acute lymphoblastic leukemia (B-ALL), relapse due to loss of the targeted is increasingly recognized as a mechanism immune escape. We hypothesized that simultaneous targeting CD19 and CD22 may improve CAR-T effect. The vitro vivo model was established, anti-tumor effects BiCAR-T, CAR-T, LoopCAR6 cells were observed. found BiCAR-T showed significant cytotoxicity vivo. CD19/CD22 bivalent CAR...
To investigate the expression and clinical relevance of Src homology region 2 domain-containing phosphatase-1 (SHP-1) suppressor cytokine signaling 6 (SOCS6) in acute leukemia (AL).The enrolled AL patients were divided into three groups (newly diagnosed, relapsed, complete remission [CR]). Healthy donors also included as a control group this study. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was performed to measure messenger RNA (mRNA) SHP-1 SOCS6. Statistical...
Abstract Nasopharyngeal carcinoma (NPC) is prevalent among populations from southern China and influenced by both genetic environmental risk factors. The monocyte chemoattractant protein‐1 (MCP‐1), a member of cysteine‐cysteine chemokine family, plays critical roles in cancers. A polymorphism within the MCP‐1 promoter, rs1024611, has been shown to be significantly associated with several Our purpose was assess role rs1024611 NPC susceptibility. By polymerase chain reaction‐restriction...
Circulating tumor DNA (ctDNA) was demonstrated as a biomarker for predicting clinical outcomes in B-cell lymphoma (BCL) patients. However, ctDNA and its minimum number of mutant genes that stratify relapsed or refractory BCL (R/R BCL) patients receiving chimeric antigen receptor (CAR)-T cell therapy remains unknown. The plasma 10 with R/R CAR-T from our center adopted targeted exome sequencing. Regarding who received therapy, their 6-, 12- 18-month overall survival (OS) rates were 90%, 80%...
Objective Neutrophil/lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker but few studies have assessed the relationship between NLR and type 2 diabetes. In order to evaluate how related diabetes, we designed a large scale cross-sectional study in adult population. Method A (including 49 861 men 40 376 women) was conducted on participants recruited from Health Management Center of Tianjin Medical University General Hospital Tianjin, China. Measurements neutrophil...
Objective To explore the safety and efficacy of chimeric antigen receptor T-cell (CAR-T) therapy for relapsed/refractory acute B-cell lymphoblastic leukemia (B-ALL) with T315I mutation. Methods The clinical data a patient B-ALL mutation who underwent CAR-T in Second Affiliated Hospital Anhui Medical University was analyzed, related literature reviewed. Results The 34-year-old man. He diagnosed chronic myelogenous (CML) January 2017 started to take imatinib orally. However,...