A5063396877- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Supercapacitor Materials and Fabrication
- Advanced Photocatalysis Techniques
- Electrocatalysts for Energy Conversion
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Advanced battery technologies research
- 2D Materials and Applications
- CRISPR and Genetic Engineering
- Advancements in Battery Materials
- Diabetes and associated disorders
- Nanomaterials for catalytic reactions
- Dental Implant Techniques and Outcomes
- Genetics and Neurodevelopmental Disorders
- Perovskite Materials and Applications
- Tissue Engineering and Regenerative Medicine
- Carbon Nanotubes in Composites
- Copper-based nanomaterials and applications
- MXene and MAX Phase Materials
- Thermal and Kinetic Analysis
- Fiber-reinforced polymer composites
- Graphene research and applications
- Advanced Nanomaterials in Catalysis
- CAR-T cell therapy research
Qingdao University of Science and Technology
2016-2025
Qingdao University
2024-2025
Affiliated Hospital of Qingdao University
2024-2025
Columbia University
2015-2024
Gannan Medical University
2023-2024
Royal College of Physicians
2023
Columbia University Irving Medical Center
2017-2023
Century Therapeutics (United States)
2022
Qilu University of Technology
2021
Qingdao Center of Resource Chemistry and New Materials
2020-2021
Graphene quantum dots (GQDs) with uniform sizes of less than 5 nm are synthesized by a novel top-down strategy. Nitric acid as strong oxidant can be used to cut graphene oxide via sonication and hydrothermal processes. Moreover, purified GQDs obtained from removing oxygen-containing functional groups in heat treatment process. Both nanoscale size edge effect improve their abundant active sites restrain the restack nanosheets. Meanwhile, electrochemical performance demonstrates properties for...
β-Cells derived from stem cells hold great promise for cell replacement therapy diabetes. Here we examine the ability of nuclear transfer embryonic (NT-ESs) a patient with type 1 diabetes to differentiate into β-cells and provide source autologous islets replacement. NT-ESs in vitro an average efficiency 55% C-peptide–positive cells, expressing markers mature β-cells, including MAFA NKX6.1. Upon transplantation immunodeficient mice, grafted form vascularized islet-like structures containing...
Permanent neonatal diabetes mellitus (PNDM) can be caused by insulin mutations. We generated induced pluripotent stem cells from fibroblasts of a patient with PNDM and undetectable at birth due to homozygous mutation in the translation start site gene. Differentiation mutant resulted insulin-negative endocrine expressing MAFA, NKX6.1, chromogranin A. Correction differentiation pancreatic restored production secretion levels comparable those wild-type cells. Grafting corrected into mice,...
Abstract Nitrogen‐doped graphene (NG) with wrinkled and bubble‐like texture is fabricated by a thermal treatment. Especially, novel sonication‐assisted pretreatment nitric acid used to further oxidize oxide its binding melamine molecules. There are many nanoflakes dimension of about 10 nm appeared on the undulated nanosheets. The provides more active sites for effective ion transport reversible capacitive behavior. specific surface area NG (5.03 at% N) can reach up 438.7 m 2 g −1 , electrode...
Heterozygous coding sequence mutations of the INS gene are a cause permanent neonatal diabetes (PNDM), requiring insulin therapy similar to T1D. While negative effects on processing and secretion known, how dominant result in continued decline beta cell function after birth is not well understood.
Recent studies with human embryonic stem (hES) cells have established new protocols for substantial generation of pancreatic progenitors from definitive endoderm. These findings add to the efficient derivation endoderm, which is controlled by Wnt and Nodal pathways, delineate a step forward in quest alternative beta-cell sources. It also indicates that critical refining available strategies might help define universal protocol differentiation applicable several cell lines, therefore offering...
Inactivation of the β-cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions during murine islet cell development differentiation human embryonic stem cells (HESCs) into insulin-producing cells. mice, determined that Neurod1 is required for perinatal proliferation α- β-cells. Surprisingly, apoptosis only makes a minor contribution to loss when deleted. HESCs severely impaired their from pancreatic progenitors insulin-expressing...
A neutral, facile and universal hydrothermal post-treatment of TiO<sub>2</sub> was developed to significantly improve its photocatalytic activity.
Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder caused by mutations in genes encoding components of the primary cilium and characterized hyperphagic obesity. To investigate molecular basis obesity human BBS, we developed cellular model BBS using induced pluripotent stem cell-derived (iPSC-derived) hypothalamic arcuate-like neurons. BBS1M390R BBS10C91fsX95 did not affect neuronal differentiation efficiency but morphological defects, including impaired neurite outgrowth...
Limitations in cell proliferation are important for normal function of differentiated tissues and essential the safety replacement products made from pluripotent stem cells, which have unlimited proliferative potential. To evaluate whether these limitations can be established pharmacologically, we exposed pancreatic progenitors differentiating human cells to small molecules that interfere with cycle progression either by inducing G1 arrest or impairing S phase entry completion determined...
Abstract Double perovskite (DP) is considered as a promising candidate for single‐component white‐light emitters. However, the photoluminescence (PL) efficiency of small sized DP, such microcrystals and nanocrystals, generally unsatisfactory. In this work, by comparing Sb/Bi co‐doped Cs 2 NaInCl 6 prepared at different conditions, it revealed that PL spectral profile are highly dependent on intrinsic strain effect. All DPs exhibit blue ≈445 nm yellow ≈560 nm. When crystal size decreases,...
2D ultrathin Z-scheme heterojunctions with excellent contact interfaces and robust internal electric fields are synthesized based on LaVO 4 ZnIn 2 S (ZIS) exhibit outstanding photocatalytic hydrogen evolution performance.
Intestinal immune dysregulation is strongly linked to the occurrence and formation of tumors. RING finger protein 128 (RNF128) has been identified play distinct immunoregulatory functions in innate adaptive systems. However, physiological roles RNF128 intestinal inflammatory conditions such as colitis colorectal cancer (CRC) remain controversial. To elucidate function mechanism CRC. Animal models dextran sodium sulfate (DSS)-induced azoxymethane (AOM)/DSS-induced CRC were established WT...
Background: The atherogenic index of plasma (AIP) is considered an important marker atherosclerosis and cardiovascular risk. However, its potential role in predicting length stay (LOS), especially patients with atherosclerotic disease (ASCVD), remains to be explored. We investigated the effect AIP on hospital LOS critically ill ASCVD explored risk factors affecting conjunction machine learning.
The electrochemical conversion of nitrate to ammonia is necessary restore the globally perturbed nitrogen cycle. Herein, regulated coordination active Cu single atoms selectively modulate energy barriers proton-electron transfer steps was investigated and offered valuable insights for improving selectivity kinetics NO3-RR.
Abstract Objective The causality between CMD and sepsis has remained largely unknown. To elucidate this, we conducted a Mendelian randomization (MR) population study. Methods Firstly, used univariable multivariable MR analyses to investigate causal associations sepsis-related outcomes. We obtained Genome-wide association study summary from both the MRC Integrative Epidemiology Unit FinnGen consortium. Subsequently, two-step mediation analysis was performed explore mediators. Afterward, an...
The atherogenic index of plasma (AIP) is considered an important marker atherosclerosis and cardiovascular risk. However, its potential role in predicting length stay (LOS), especially patients with atherosclerotic disease (ASCVD), remains to be explored. We investigated the effect AIP on hospital LOS critically ill ASCVD explored risk factors affecting conjunction machine learning. Using data from Medical Information Mart for Intensive Care (MIMIC)-IV. was calculated as logarithmic ratio TG...