A5001779121- Ruminant Nutrition and Digestive Physiology
- Reproductive Physiology in Livestock
- RNA modifications and cancer
- Animal Virus Infections Studies
- Animal health and immunology
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Graphene and Nanomaterials Applications
- Nuts composition and effects
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Genetic and phenotypic traits in livestock
- Nanoplatforms for cancer theranostics
- Spine and Intervertebral Disc Pathology
- Plant Disease Resistance and Genetics
- Gout, Hyperuricemia, Uric Acid
- Plant pathogens and resistance mechanisms
- Animal Disease Management and Epidemiology
- Cancer-related Molecular Pathways
- Viral Infections and Immunology Research
- Congenital Anomalies and Fetal Surgery
- Hepatitis B Virus Studies
- Plant-Microbe Interactions and Immunity
- Hepatitis C virus research
Huazhong Agricultural University
2020-2024
Ministry of Agriculture and Rural Affairs
2020-2024
Tianjin Medical University
2022-2024
Southwest Minzu University
2024
Shanghai Medical College of Fudan University
2024
Anhui Agricultural University
2024
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting swine industry worldwide. To investigate role miRNAs in infection susceptibility PRRS virus (PRRSV), twenty-four miRNA libraries were constructed sequenced from PRRSV-infected mock-infected alveolar macrophages (PAMs) Meishan, Landrace, Pietrain Qingping pigs at 9 hours post (hpi), 36 hpi, 60 hpi. The let-7 family significantly differentially expressed between PAMs 4 pig...
Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease caused by virus (PRRSV), results in huge economic losses to the world pig industry. MiRNAs have been reported be involved regulation of viral infection. In our study, miR-320 was one 21 common differentially expressed miRNAs Meishan, Pietrain, Landrace breeds at 9-h post-infection (hpi). Bioinformatics experiments found that PRRSV replication inhibited through directly targeting ORF6. addition, expression CCAAT...
Porcine reproductive and respiratory syndrome (PRRS) caused by a single-stranded RNA virus, PRRSV, is highly infectious disease leads to huge economic losses the swine industry worldwide. To investigate role of miRNAs in infection lung injury induced differentially expressed (DE-miRs) were isolated from PRRSV infected/mock-infected PAMs Meishan, Landrace, Pietrain Qingping pigs at 9hpi, 36hpi, 60hpi. Mir-331-3p was only common DE-miR 4 pig breeds 36hpi one DE-miRs Landrace Mir-210 7...
Grain processed by lactic acid (LA) is known to improve ruminant growth and health. However, the exact mechanism regarding rumen hydrolysis of LA-treated grain still ambiguous. This experiment was designed compare effects 5% LA treatment on trophic morphological variations in corn discover alternations ruminal between untreated macroscopically microscopically using vitro fermentation method. The results showed that, compared with (CN), treated for 48 h (CNLA) experienced a decrease dry...
Abstract In this study, we characterized the effects of CT dietary inclusion at 2% (wt/wt) dry matter on goat rumen metabolome and fermentation characteristics. Barley (BA) corn (CN) were separately used as basal grain for control rations, rations supplemented with BACT CNCT, respectively. The tested using eight Japanese Shiba × Saanen goats in a replicated 4 Latin square arrangement (28 days each period). Ruminal fluid was obtained day 25 period, ultra‐performance liquid chromatography–mass...
The endometrium is an important tissue for pregnancy and plays role in reproduction. In this study, high-throughput transcriptome sequencing was performed samples of Meishan Yorkshire pigs on days 18 32 pregnancy. Aldo-keto reductase family 1 member C1 (AKR1C1) found to be a differentially expressed gene, identified by quantitative real-time PCR (qRT-PCR) Western blot. Immunohistochemistry results revealed the cellular localization AKR1C1 protein endometrium. Luciferase activity assay...
Purpose: N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification catalyzed by N-acetyltransferase 10 (NAT10), critical factor known to influence mRNA stability. However, the role of ac4C in visual development remains unexplored. Methods: Analysis public datasets and immunohistochemical staining were conducted assess expression pattern nat10 zebrafish. We used CRISPR/Cas9 RNAi technologies knockout (KO) knockdown (KD) nat10, zebrafish ortholog human NAT10, evaluated its effects on...
Abstract In this comprehensive genome-wide study, we identified and classified 83 Xylanase Inhibitor Protein (XIP) genes in wheat, grouped into five distinct categories, to enhance understanding of wheat's resistance Fusarium head blight (FHB), a significant fungal threat global wheat production. Our analysis reveals the unique distribution XIP across chromosomes, particularly at terminal regions, suggesting their role evolutionary expansion gene family. Several lack signal peptides,...
Colostrum is a vital performance for buffaloes and potentially functional foods in the future. Therefore, this study aimed to evaluate difference between parity of buffalo colostrum mature milk. Twenty pregnant (primiparous = 10; multiparous 10) were assigned same diet prepartum milking routine postpartum. Calves separated from dams immediately after birth was harvested within 2 h, whilst milk at 7 days The analyzed immunoglobulin G composition as results showed that there higher level...
This study aimed to determine the effect of capsicum oleoresin (CAP) on rumen fermentation and microbial abundance under different temperature dietary conditions in vitro. The experimental design was arranged a 2 × 3 factorial format together with two temperatures (normal: 39°C; hyperthermal: 42°C), forage/concentrate ratios (30:70; 70:30), CAP concentrations incubation fluid at 20 200 mg/L control group. Regarding characteristics, high reduced short-chain fatty acids (SCFA) production...
The present study aims to evaluate the effects of prepartum maternal supplementation Capsicum oleoresin (CAP) on colostrum quality and growth performance in newborn buffalo calves. Twelve multiparous buffaloes were randomly assigned two groups starting from 4 weeks prepartum: control group with a basal diet (CON) treatment supplemented 20 mg CAP/kg dry matter (CAP20). After birth, all calves weighed received their respective dam directly within 2 h. that, pasteurized milk starter feed till...
In recent years, there are few reports on non-SMC condensin I complex subunit G (NCAPG) in osteosarcoma. Our study aims to explore the biological role of NCAPG osteosarcoma and its underlying molecular mechanism further clarify reasons for abnormal expression
Due to the limitations of current anti-HBV therapies, HBV core (HBc or HBcAg) protein assembly modulators (CpAMs) are believed be potential agents. Therefore, discovering safe and efficient CpAMs is great value. In this study, we established a HiBiT-based high-throughput screening system targeting HBc screened novel from an in-house marine chemicals library. A lead compound
Abstract Spinal fusion technique is widely used in the treatment of lumbar degeneration, cervical instability, disc injury, and spinal deformity. However, it usually accompanied by a high incidence failure pseudoarthrosis, placing higher demands on bone implants. Therefore, materials with good biocompatibility, osteoconductivity, even induce ingrowth, which can be to improve rate regeneration, have become hot research topic. Here, ultra‐small cerium oxide nanoparticles (CeO 2 NPs) are...
Abstract N4-acetylcytidine (ac4C) is an epitranscriptomic modification of mRNA that catalyzed by N-acetyltransferase 10 (NAT10), a critical factor known to influence stability. However, its role in development has not been investigated. In this study, we used CRISPR/Cas9 and RNAi technology knock out down nat10 , the zebrafish ortholog human NAT10, evaluated their effects on development, behavior, transcriptome. Our findings indicate deficiency embryos results increased embryo mortality...
Ruminant products are important sources of odd- and branched-chain fatty acids (OBCFA) for humans, their content could be influenced by dietary feedstuffs supplements. This experiment was carried out to test the interactions grains condensed tannin (CT) on rumen plasma OBCFA goats. A 2 × treatment with (corn [CN] or barley [BA]) CT levels (0 2% wt/wt) applied resulted in 4 diets. Then, diets were tested using eight Japanese Shiba Saanen goats allocated a replicated (diets) (squares, per...