A5028304295- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Gout, Hyperuricemia, Uric Acid
- Calcium signaling and nucleotide metabolism
- RNA Interference and Gene Delivery
- Blood disorders and treatments
- Tryptophan and brain disorders
- Autoimmune and Inflammatory Disorders
- Vitamin C and Antioxidants Research
- Diabetes Management and Education
- Health Policy Implementation Science
- Genomics and Chromatin Dynamics
- Immune cells in cancer
- Neutropenia and Cancer Infections
- Child Nutrition and Feeding Issues
- Epigenetics and DNA Methylation
- Gastrointestinal motility and disorders
- Cancer therapeutics and mechanisms
- DNA and Nucleic Acid Chemistry
- Celiac Disease Research and Management
- Antifungal resistance and susceptibility
National Institute of Environmental Health Sciences
2017-2023
Research Triangle Park Foundation
2023
National Institutes of Health
2017-2022
University of Georgia
2014-2016
University of Hawaiʻi at Mānoa
2011-2013
Biogen (United States)
2011
University of Hawaii System
2010
Pseudomonas aeruginosa is an opportunistic pathogen causing severe infections often characterized by robust neutrophilic infiltration. Neutrophils provide the first line of defense against P. aeruginosa. Aside from their conferred phagocytic activity, neutrophils also release neutrophil extracellular traps (NETs) to immobilize bacteria. Although NET formation important antimicrobial process, details its mechanism are largely unknown. The identity main components responsible for triggering...
Abstract Human neutrophils (polymorphonuclear leukocytes [PMNs]) generate inflammatory responses within the joints of gout patients upon encountering monosodium urate (MSU) crystals. Neutrophil extracellular traps (NETs) are found abundantly in synovial fluid patients. The detailed mechanism MSU crystal–induced NET formation remains unknown. Our goal was to shed light on possible roles purinergic signaling and neutrophil migration mediating induced by Interaction human with crystals...
Neutrophil granulocytes are the most abundant leukocytes in human blood. Neutrophils first to arrive at site of infection. developed several antimicrobial mechanisms including phagocytosis, degranulation and formation neutrophil extracellular traps (NETs). NETs consist a DNA scaffold decorated with histones granule markers myeloperoxidase (MPO) elastase (HNE). NET release is an active process involving characteristic morphological changes neutrophils leading expulsion their into space....
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads development diseases both humans mice. However, despite the well-established causal relationship between immunity, little known about involvement regulation antitumor foundation modern immunotherapy. In this study, we identify as a potentially new regulator immunity tumor suppressor colon cancer. humans, downregulated...
BackgroundControl of the inflammatory response is critical to maintaining homeostasis, and failure do so contributes burden chronic inflammation associated with several disease states. The mechanisms that underlie immunosuppression, however, remain largely unknown. Although defects in autophagy machinery have been pathologic conditions, we now appreciate autophagic components participate noncanonical pathways distinct from classical autophagy. We previously demonstrated LC3-associated...
In 2010, approximately 79 million Americans had prediabetes and about 50 percent of those individuals were 65 years older. The most effective diabetes prevention method in prediabetic adults is lifestyle modification. However, despite the benefits change, prevalence continues to increase. Maintaining a regular exercise routine healthy eating plan may be difficult because negative emotional barriers (i.e., stress, mood) that individual faces. This particularly evident older when you combine...
Neutrophil granulocytes are the most abundant leukocytes in human blood. Neutrophils first to arrive at site of infection. developed several antimicrobial mechanisms including phagocytosis, degranulation and formation neutrophil extracellular traps (NETs). NETs consist a DNA scaffold decorated with histones granule markers myeloperoxidase (MPO) elastase (HNE). NET release is an active process involving characteristic morphological changes neutrophils leading expulsion their into space....
Summary Major Histocompatibility Complex I (MHC-I) molecules classically present peptides derived from endogenous antigens, but exogenous antigens can also gain access to the MHC-I machinery in dendritic cells (DCs), which activate antigen-specific CD8 + T cells. This process, termed cross-presentation, be triggered by uptake of dying autologous cells, including tumor DCs. The molecular mechanisms that underlie efficient cross-presentation remain largely uncharacterized, and an improved...
Abstract Human neutrophils generate inflammatory responses within the joints of gout patients upon encountering Monosodium Urate (MSU) crystals. Studies (including ours) show that neutrophil extracellular traps (NETs) are found abundantly in synovial fluid (SF) and crucial for onset autoinflammatory cascade. Our goal is to shed light on possible roles purinergic signaling migration mediating vitro NET formation induced by MSU data SF supernatants have significantly higher levels granule...
INTRODUCTION: DNA replication in the one-cell embryo has several unique features that differ from more frequently studied somatic cells. It is only time maternal and paternal genomes undergo different processes same cell. The life of zygote begins with completing meiosis being decondensed. Each genome then housed within separate pronuclei before eventually existing nucleus two-cell stage. initial differences chromatin structure result two developing asynchronously, pronucleus forming...
Abstract The cancer immunotherapy field has seen an increasing demand for identifying and characterizing pre-clinical models to evaluate the efficacy of checkpoint inhibitors such as, ipilimumab pembrolizumab. PBMC- or CD34-humanized mouse are invaluable tools assess effector functions human T-cells immune check point (ICI). However, these offer limited understanding overall potential therapeutic activity as they lack a complete repertoire cells required elicit full response. Thus,...