A5007364999- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Protein Degradation and Inhibitors
- Phosphodiesterase function and regulation
- MicroRNA in disease regulation
- Immune cells in cancer
- High Altitude and Hypoxia
- Cellular transport and secretion
- ATP Synthase and ATPases Research
- Circular RNAs in diseases
- Tryptophan and brain disorders
- interferon and immune responses
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
Second Affiliated Hospital of Guangzhou Medical University
2018-2024
Guangzhou Medical University
2018-2024
Soochow University
2024
The Military General Hospital of Beijing PLA
2015-2018
Southern Medical University
2015-2018
Bayi Children's Hospital
2015-2018
Abstract Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels Disrupted‐in‐schizophrenia‐1 (DISC1), genetically psychiatric disorders and AD, decrease the brains AD patients transgenic model mice Aβ‐treated cultured cells. contains a canonical LC3‐interacting region (LIR) motif ( 210 FSFI 213 ), through DISC1 directly binds LC3‐I/II....
Abstract PRMT6, a type I arginine methyltransferase, di-methylates the residues of both histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays tumor mediator involved in human malignancies. Here, we aim to uncover essential role underlying mechanisms promoting glioblastoma (GBM) proliferation. Investigation expression glioma tissues demonstrated is overexpressed, elevated negatively correlated with poor prognosis glioma/GBM patients. Silencing inhibited GBM...
The cerebellum plays an essential role in balance and motor coordination. Purkinje cells (PCs) are the sole output neurons of cerebellar cortex critical for execution its functions, including Toll-like receptor (TLR) 4 is involved innate immune response abundantly expressed central nervous system; however, little known about cerebellum-related functions. To address this question, we evaluated behavior TLR4 deficient mice. We found that TLR4(-∕-) mice showed impaired Morphological analyses...
Abstract Background Tyrosine protein tyrosine kinase binding (TYROBP) binds non-covalently to activated receptors on the surface of various immune cells, and mediates signal transduction cellular activation. It is dysregulated in malignancies, although little known regarding its role low-grade glioma. The aim this study explore clinicopathological significance, prognostic value signature TYROBP expression glioma (LGG). Methods differentially expressed genes (DEGs) between samples normal...
Paeoniflorin (PF) is a polyphenolic compound derived from Radix Paeoniae Alba thathas anti-cancer activities in variety of human malignancies including glioblastoma. However, the underlying mechanisms have not been fully elucidated. Epithelial to mesenchymal transition (EMT), characterized as losing cell polarity, plays an essential role tumor invasion and metastasis. TGFβ, key member transforming growth factors, has demonstrated contribute glioblastoma aggressiveness through inducing EMT....
As a natural antioxidant, verbascoside (VB) is proved to be promising method for the treatment of oxidative-stress-related neurodegenerative diseases. Thus, this study aimed investigate effects VB on glioblastoma cell proliferation, apoptosis, migration, and invasion as well mechanism involving signal transducer activator transcription 3 (STAT3) Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1).U87 cells were assigned different treatments. The MTT assay was used test...
Background and Purpose As a hallmark of glioblastoma multiforme (GBM), CD44 plays crucial role in promoting stem cell (GSC) stemness phenotypes multiple drug resistance. The therapeutic potential has been validated by the clinical successes several inhibitors, including antibodies hyaluronan‐related drugs. Experimental Approach We used systemsDock software to predict verbascoside as candidate inhibitor. Microscale thermophoresis was confirm interaction between verbascoside. Four lines...
Paeoniflorin (PF), as one of the important valid natural compounds total glucosides peony, has displayed a potential effect in cancer prevention and treatment. Aggressive migration invasion, an process, can contribute to tumor progression through infiltrating surround normal tissue. Actin cytoskeleton rearrangement plays key role cells involving multiple signal pathways. HGF/c-Met signal, couple oncoprotein, been demonstrated regulate actin rearrangement. In our study, we aim explore whether...
Paeoniflorin, a polyphenolic compound derived from Radix Paeoniae Alba (Paeonia lactiflora), has exhibited anticancer activity in various human cancers, including glioblastoma. However, the mechanisms underlying effects of this have not been fully elucidated. Toll-like receptor 4 (TLR4) plays an important role regulation cancer cell proliferation and progression, high TLR4 expression glioblastoma specimens is associated with poor prognosis. The present study aimed to investigate whether...
Aging | doi:10.18632/aging.205063. Kairong Liang, Zhaoxiong Guo, Shizhen Zhang, Danmin Chen, Renheng Zou, Yuhao Weng, Chengxiang Peng, Zhichao Xu, Jingbai Xiaorui Liu, Xiao Pang, Yunxiang Ji, Degui Liao, Miaoling Lai, Huaidong Yanbin Ke, Zhaotao Wang, Yezhong Wang
Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied experimental models clinical trials for treatment because of its anti-cancer property. However, the underlying mechanisms paeoniflorin EMT glioblastoma was not fully elucidated. The present study aimed to investigate whether inhibits angiogenesis, which involving c-Met suppression, while exploring potential ways degradation. In our study,...
Intracerebral hemorrhage (ICH) represents a common acute cerebrovascular event that imparts high rates of disability.The microglia-mediated inflammatory response is critical factor in determining cerebral damage post-ICH.Clemastine (CLM) histamine receptor H1 (HRH1) antagonist has been shown to modulate the response.However, effects CLM on ICH and underlying mechanism remain be determined.This investigation reveals resulted reduction hematoma volume, decreased edema lower neuronal apoptosis...
Despite emerging evidence revealing the remarkable roles of protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A) in cancer tumorigenesis and progression, no pan-cancer analysis is available. A comprehensive investigation potential carcinogenic mechanism PPP1R14A across 33 tumors using bioinformatic techniques reported for first time. downregulated major malignancies, there a significant correlation between expression prognosis patients. The high most cases was associated with...
Abstract The role of SLC3A2, a gene implicated in disulfidptosis, has not been characterized gliomas. This study aims to clarify the prognostic value SLC3A2 and its influence on glioma. We evaluated expression importance gliomas using publicly accessible databases our clinical glioma samples with reliance Meta Cox regression analysis approaches. Functional enrichment analyses were performed explore SLC3A2's function. Immune infiltration was CIBERSORT, ssGSEA, single-cell sequencing data....
To investigate the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) in neurosurgery their impact on occurrence prognosis of acute traumatic progressive hemorrhagic brain injury (PHI) among patients. A retrospective analysis encompassed 220 patients treated 2019 2022. Patients were categorized into two groups: those experiencing without PHI. The levels examined within each group. Within PHI cohort, further stratified based Glasgow Outcome Scale (GOS)...
Proper functioning of the cerebellum is crucial to motor balance and coordination in adult mammals. Purkinje cells (PCs), sole output neurons cerebellar cortex, play essential roles function. Tripartite motif-containing protein 32 (TRIM32) an E3 ubiquitin ligase that involved activities neurogenesis subventricular zone mammalian brain development many nervous system diseases, such as Alzheimer's disease, autism spectrum disorder, attention deficit hyperactivity disorder. However, role TRIM32...
Alzheimer's disease (AD) is a form of neurodegenerative in the elderly with no cure at present. In previous study, we found that scaffold protein, disrupted Schizophrenia 1 (DISC1) down-regulated AD brains, and ectopic expression DISC1 can delay progression by protecting synaptic plasticity down-regulating BACE1. However, underlying mechanisms remain not to be elucidated. present compared proteomes normal DISC1high cells expressing amyloid precursor protein (APP) using isobaric tag for...