Abstract Background Ovarian cancer (OC) is one of the most common gynecological tumors with high morbidity and mortality. Altered serum N -glycome has been observed in many diseases, while association between protein -glycosylation OC progression remains unclear, particularly for onset carcinogenesis from benign neoplasms to cancer. Methods Herein, a mass spectrometry based high-throughput technique was applied characterize profile individuals healthy controls, different stages OC. To...

Background: Progesterone, recommended for preventing preterm birth (PTB) in high-risk women, is traditionally administered via oral capsules, vaginal gels, and oil injections, which pose issues like low bioavailability, systemic side effects, irritation, leading to reduced compliance. To address these issues, a user-friendly administration approach deliver progesterone was needed development the prevention of PTB. Methods: We developed microemulsion using ultra high-speed homogenization,...

The concrete-filled steel tubular (CFST) K-joint was taken as the research object, full-scale specimen tests and finite-element (FE) analysis of seven CFST K-joints one (ST) were carried out. accuracy stress concentration coefficient (SCF) calculation using existing SCF formula discussed. Based on effect core concrete chord deformation mechanism, releasing proposed. According to relationship between stripping arc length, method established by theoretical derivation. then based ST SCF....

To avoid fatigue cracking of K-joints in concrete-filled steel-tube (CFST) truss arch bridges, performance tests and finite-element analysis were conducted to investigate the hot spot stress distribution, evolution, final failure pattern CFST K-joints. The results a K-joint compared with those steel tube (ST) K-joint, reveal influence concrete filled chord on K-joint. show that can be obtained by quadratic extrapolation. concentration factor (SCF) side intersecting weld is larger than brace...

This study aims to compare the effects of three calcium compounds on workability, setting time and mechanical properties red mud (RM)-blast furnace slag (BFS)-based geopolymers. The crystalline phase, hydration process microstructure RM-BFS-based geopolymers were characterized by X-ray diffraction (XRD), heat evolution, photoelectron spectroscopy (XPS), scanning electron microscope (SEM) tests. results showed that an appropriate amount can improve flowability compressive strength...

Eight monoclonal antibodies reactive with the matrix protein of human immunodeficiency virus type 1 (HIV-1), p17gag, were isolated from rats which had been immunized solubilized HIV-1 lysate. The epitope specificities these determined a series synthetic peptides representing overlapping regions p17. Six mapped to three distinct p17, while two (G11g1 and G11h3) reacted only intact recombinant suggesting that they directed against conformational or discontinuous epitopes. All bound...

The activation of tumor cell immunogenicity through oxaliplatin (OXP)-induced immunogenic death (ICD) has significant implications in cancer treatment. However, the anti-tumor effect OXP monotherapy still many shortcomings, and systemic administration leads to low drug concentration at site, which is susceptible toxic side effects. In this study, a combined therapeutic strategy using folate-modified nanoliposomes co-delivered with rapamycin (Rapa) (abbreviated as FA@R/O Lps) proposed for...

To observe the effect of puerarin on learning and memory function tau phosphorylation in APP/PS1 transgenic mice, drugs were administered to 3-month old mice. Learning mice assessed by Morris water maze test 3 months after treatment. Animals decapitated behavioral test. The levels Aβ detected ELISA, expression protein [tau, phosphorylated tau, GSK3β p-GSK3β(Ser9)] Western blot. showed that escape latency double was significantly longer than normal control group, residence time original...

To analyze the reason why fatigue cracking appeared on rib joint of a half-through concrete filled steel tubular (CFST) truss arch, finite element (FE) analysis is carried out by establishing full-bridge FE model using software MIDAS/CIVIL. By studying variation stress amplitude arch under different vehicle loads and geometric parameters respectively, influence overloading, medium loading unbalanced analyzed. Furthermore, also discussed. It found that linearly increases with overloading...

As a new type of composite girders, girders with corrugated steel webs and concrete-filled tubular (CSW-CFST) truss chords are extensively utilized in bridge engineering. To examine the structural behavior CSW-CFST subjected to combined flexure torsion, model tests finite element analysis (FEA) employed. Using these efficient tools, strain distribution, deformation law, failure mode, bearing capacity pure torsion methodically obtained. The primary objectives probe applicability existing...

Protein glycosylation is associated with the pathogenesis of various cancers. The utilization certain glycans in cancer diagnosis models holds promise, yet their accuracy not always guaranteed. Here, we investigated utility deep learning techniques, specifically random forests combined transfer learning, enhancing serum glycome's discriminative power for (including ovarian cancer, non-small cell lung gastric and esophageal cancer). We started demonstrated that can achieve superior...

Composite girders with corrugated steel webs and concrete-filled tubular (CSW-CFST) truss chords are a new type of structure have been used in bridges. To study the fatigue performance these composite girders, model tests numerical analysis were conducted, results compared those for (CSW-ST) chords. The indicated that concrete-filling constrained chord radial deformation relieved hot-spot stress intersecting weld zones CSW-ST by 18.5–60.1%. crack growth rates along both depth length...

The evolution of hinged joint structures in Chinese hollow-slab bridges was summarized to study the mechanical performance with gate-type steel bars. Parameter analysis conducted nonlinear finite element method for a bridge span 8 m. failure mode structure different parameters, including crack-occurring load and crack distribution, studied. Countermeasures improve were also discussed. Results showed that adopting bar at bottom junction surface did not joint, but full-length improved,...

To study the fatigue performance of a composite girder with corrugated steel web (CSW) and tube (ST) truss, based on an engineering object, test finite element (FE) analysis were carried out. The failure mode sensitivities hot spot stress to geometric parameters above studied. position maximum crack discussed determined. Furthermore, life evaluation method was discussed. It found that linear extrapolation applicable finding stress. evolution comprised three stages, including initiation,...

To study the flexural behavior of composite girders with concrete-filled steel tubular (CFST) truss chords under positive and negative bending moments, model tests, theoretical analysis were carried out to investigate evolution their bearing capacity. The results showed that web members joints CFST subjected moments had high strength rigidity, which ensured joint failures did not occur before failure entire cross section. longitudinal strains along member axis changed linearly...