A5089769051- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Advanced Computational Techniques and Applications
- Biomarkers in Disease Mechanisms
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cytokine Signaling Pathways and Interactions
- Customer churn and segmentation
- Advanced Nanomaterials in Catalysis
- Circular RNAs in diseases
- Wireless Sensor Networks and IoT
- Heme Oxygenase-1 and Carbon Monoxide
- Imbalanced Data Classification Techniques
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Sulfur Compounds in Biology
Wuhan University
2018-2025
Renmin Hospital of Wuhan University
2018-2025
Tongji Hospital
2025
Huazhong University of Science and Technology
2025
Anhui University of Science and Technology
2025
Huazhong Agricultural University
2010-2021
The cerebral ischemia injury can result in neuronal death and/or functional impairment, which leads to further damage and dysfunction after recovery of blood supply. Cerebral ischemia/reperfusion (CIRI) often causes irreversible brain death, involves many complex pathological processes including oxidative stress, amino acid toxicity, the release endogenous substances, inflammation apoptosis. Oxidative stress are interactive play critical roles brain. is important process ischemic stroke for...
Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral ischemic stroke (IS). Ruxolitinib (Rux), selective oral JAK 1/2 inhibitor, reduces inflammatory via JAK2/STAT3 pathway. Based on its anti-inflammatory and immunosuppressive effects, we hypothesized that it may have protective effect against stroke. The aim this study was to investigate whether inhibition JAK2 has neuroprotective explore potential molecular mechanisms. Methods Rux, MCC950 or vehicle...
Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis unclear and treatments are limited. Meisoindigo, second-generation derivative of indirubin, has general water solubility well tolerated. Previous studies have shown that meisoindigo reduces inflammation by inhibiting leukocyte chemotaxis migration. In present study, we investigated hypothesis was also protective against ischemic stroke, then evaluated its underlying mechanisms. vivo, adult male...
Reactive oxygen species (ROS) often promote acute brain injury after stroke, but their roles in the recovery phase have not been well studied. We tested hypothesis that ROS activity mediated by NADPH oxidase 2 (NOX2) contributes to promotes functional during delayed phase, which is linked with neuroinflammation, autophagy, angiogenesis, and PI3K/Akt signaling pathway.We used NOX2 inhibitor apocynin study role of a middle cerebral artery occlusion (MCAO) stroke mouse model. Infarct size,...
The role of ferroptosis in ischemic stroke has been hotly debated recently, but the mechanism is not clearly clarified. It reported that NLRP3 inflammasome essential for progression stroke. Whether after mediated by activation still reported. In this study, we investigated effect deficiency on following cerebral ischemia-reperfusion injury (CIRI) vivo and vitro.In vivo, used C57BL/6J mice NLRP3-/- to establish a model middle artery occlusion (MCAO). After 3 days reperfusion, assessed...
Ischemic stroke is a leading cause of permanent disability and death globally. The nucleotide-biding oligomaerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome multi-protein complex that plays role in ischemic stroke. Recently, research on the NLRP3 has developed rapidly worldwide. However, there no bibliometric analysis to date.Through analysis, aim this study was assess current state field worldwide over past 12 years identify important results, major...
Abstract Aims Cell death, except for cuproptosis, in gliomas has been extensively studied, providing novel targets immunotherapy by reshaping the tumor immune microenvironment through multiple mechanisms. This study aimed to explore effect of cuproptosis on and its predictive power prognosis response. Methods Eight glioma cohorts were included this study. We employed unsupervised clustering algorithm identify clusters described their microenvironmental characteristics, mutation landscape,...
Phosphatidylinositol binding clathrin assembly protein interacting mitotic regulator (PIMREG) localizes to the nucleus and can significantly elevate nuclear localization of lymphomedullary leukocythemia gene. Although there is some evidence support an important action for PIMREG in occurrence development certain cancers, currently no pan-cancer analysis available. Therefore, we intended estimate prognostic predictive value explore its potential immune function 33 cancer types. By using a...