A5100458554- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Renal Diseases and Glomerulopathies
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- CO2 Reduction Techniques and Catalysts
- Corporate Finance and Governance
- Catalytic Processes in Materials Science
- Consumer Market Behavior and Pricing
- Ion Channels and Receptors
- Endoplasmic Reticulum Stress and Disease
- Carbon dioxide utilization in catalysis
- Ion Transport and Channel Regulation
- Catalysis for Biomass Conversion
- Natural Compounds in Disease Treatment
- Financial Markets and Investment Strategies
- Recommender Systems and Techniques
- Antioxidant Activity and Oxidative Stress
- Genetic and Kidney Cyst Diseases
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Nanoparticles: synthesis and applications
- Neural dynamics and brain function
- Pain Management and Placebo Effect
Heze Medical College
2023-2025
Nankai University
2014-2024
State Key Laboratory of Medicinal Chemical Biology
2015-2024
Tianjin Medical University
2023
Tianjin University
2023
Peking University
2021-2023
Beijing National Laboratory for Molecular Sciences
2021-2023
Second Hospital of Shandong University
2023
First Affiliated Hospital Zhejiang University
2023
Hohai University
2022
Significance Basal lateral amygdala and ventral CA1 are critical sites during chronic stress-induced depression. Here we demonstrated that AMPARs mediated weakening of pBLA-vCA1 innervation in mice subjected to CUMS. Stimulation via chemogenetics or administration cannabidiol (CBD) could reverse synaptosomal AMPAR decrease alleviate CUMS-induced depressive-like behaviors. These findings highlighted the importance an animal model depression revealed potential for CBD major treatment.
Tax payments stimulate business enterprises to choose tax management through avoidance activities, which is the legal practice reduce amount of payable. In developing economies, taxation considered more critical for budget and revenues a country. This paper investigates whether various strategies influence corporate decisions firms by adopting strategies. Besides, it explores how gender diversity can ease this relationship. study has chosen sample organizations from non-financial sector in...
Abstract Considerable attention has been drawn to tune the geometric and electronic structure of interfacial catalysts via modulating strong metal-support interactions (SMSI). Herein, we report construction a series TiO 2− x /Ni catalysts, where disordered overlayers immobilized onto surface Ni nanoparticles (~20 nm) are successfully engineered with SMSI effect. The optimal catalyst shows CO conversion ~19.8% in Fischer – Tropsch synthesis (FTS) process under atmospheric pressure at 220 °C....
Accumulation of pathological tau is a hallmark Alzheimer's disease (AD), which correlates more closely with cognitive impairment than does the amyloid-β (Aβ) burden. Autophagy powerful process for clearance toxic proteins including aberrant tau. However, compromised autophagy demonstrated in neurodegeneration AD, and current inducers remain enormously challenging due to inability restoring pathway lack targeting specificity. Here, pathogenic tau-specific based on customized nanochaperone...
Diabetic encephalopathy (DE) is a common central nervous system complication resulting from diabetes mellitus (DM). While the exact pathogenesis remains unclear, homeostatic imbalance of mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) within neurons has been shown to be closely associated with dysfunctional cognitive pathology this condition. Our previous work revealed that phosphatidate phosphatase Lipin1 plays critical role in processes DE via regulating mitochondrial...
Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary cause pathogenesis Alzheimer's disease (AD). And elimination Aβ25-35 is considered important target for treatment AD. Triptolide (TP), isolated from Tripterygium wilfordii Hook.f. (TWHF), has been shown to possess a broad spectrum biological profiles, including neurotrophic and neuroprotective effects. In our study investigating effect potential mechanism triptolide on cytotoxicity...
Recommender systems assign products to slots in ways that improve consumers' experience when choosing what buy.They usually lead more sales, which increases both consumer surplus and profit.However, firms may also choose recommender system use maximize profit.Furthermore, consumers tend exhibit a lower price elasticity of demand towards placed salient slots.We show firm using this knowledge increase its profit hurting total welfare.We data from large scale field experiment ran the...
Carbonate hydrogenation to formate is a promising route convert captured carbon dioxide into valuable chemicals, thus reducing emissions and creating revenue return. Developing inexpensive catalysts with high activity, selectivity, stability remains challenging. We report supported non-noble metal catalyst, Ni/TiO2 , great selectivity over 96 % excellent in catalyzing the conversion of carbonate aqueous solution. Ni0 Ni2+ species are both observed catalysts, synergistic effect these two Ni...
Cell death is a vital event in life. Infections and injuries cause lytic cell death, which gives rise to danger signals that can further induce inflammation, tissue damage. The mevalonate (MVA) pathway an essential, highly conserved dynamic metabolic pathway. Here, we discover farnesyl pyrophosphate (FPP), intermediate of the MVA pathway, functions as newly identified signal trigger acute leading neuron loss stroke. Harboring both hydrophobic 15-carbon isoprenyl chain heavily charged head,...
AMPA receptors (AMPARs) play a critical role in synaptic plasticity and learning memory, dysfunction or dysregulation of AMPARs could lead to various neurological psychiatric disorders, such as Alzheimer's disease (AD). However, the dynamics and/or longitudinal changes vivo during AD pathogenesis remain elusive. Here, employing 5xFAD SEP-GluA1 KI mice, we investigated endogenous receptor whisker deflection-associated Go/No-go paradigm. We found significant increase synaptosomal subunits...
Plasmid-mediated quinolone resistance (PMQR) remains one of the main mechanisms bacterial and plays an important role in transmission antibiotic genes (ARGs). In this study, two novel plasmids, p3M-2A p3M-2B, which mediate Proteus vulgaris strain 3M (P3M) were identified. Of these, only p3M-2B appeared to be a qnrD-carrying plasmid. Both could transferred into Escherichia coli, latter caused twofold change ciprofloxacin resistance, according measured minimum inhibitory concentration (MIC)....
Postoperative pain control is a challenge in enhanced recovery after surgery (ERAS). The current study reviewed the efficacy and safety of incorporating acupoint stimulation for postoperative ERAS.
Recommender systems assign products to slots in ways that improve consumers’ experience when choosing what buy. They usually lead more sales, which increases both consumer surplus and profit. However, firms may also choose recommender system use maximize Furthermore, consumers tend exhibit a lower price elasticity of demand towards placed salient slots. We show firm using this knowledge increase its profit hurting total welfare. data from large scale field experiment ran the video-on-demand...