A5103599519- Respiratory viral infections research
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Gestational Diabetes Research and Management
- Influenza Virus Research Studies
- Topic Modeling
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Machine Learning in Healthcare
- Salmonella and Campylobacter epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Disease Management and Epidemiology
- Pneumonia and Respiratory Infections
- Indoor Air Quality and Microbial Exposure
- Antibiotic Resistance in Bacteria
- Artificial Intelligence in Healthcare
- Birth, Development, and Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Infection Control and Ventilation
- Air Quality and Health Impacts
- Melamine detection and toxicity
- HIV/AIDS drug development and treatment
- Nanoparticles: synthesis and applications
International Peace Maternity & Child Health Hospital
2022-2025
Obstetrics and Gynecology Hospital of Fudan University
2020-2024
Shandong Agricultural University
2013-2024
Shanghai Jiao Tong University
2022-2024
Chongqing Medical University
2021-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Peking Union Medical College Hospital
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Stomatological Hospital of Chongqing Medical University
2023
Zhengzhou Children's Hospital
2022
Accurate third-trimester birth weight prediction is vital for reducing adverse outcomes, and machine learning (ML) offers superior precision over traditional ultrasound methods. This study aims to develop an ML model on the basis of clinical big data accurate in third trimester pregnancy, which can help reduce maternal fetal outcomes. From January 1, 2018 December 31, 2019, a retrospective cohort involving 16,655 singleton live births without congenital anomalies (>28 weeks gestation) was...
Abstract Background The novel swine-origin influenza A (H1N1) virus (S-O 2009 IV) can cause respiratory infectious diseases in humans and pigs, but there are few studies investigating the airborne spread of virus. In January 2011, a H1N1 epidemic emerged eastern China that rapidly to neighboring farms, likely by aerosols carried wind. Methods this study, quantitative reverse transcription polymerase chain reaction (RT-PCR) was used detect viruses air samples from pig farms. Based on two...
Objective The aim of this study was to evaluate the potential metagenomic next-generation sequencing (mNGS) for diagnosis pneumocystis pneumonia (PCP) in patients with non-human immunodeficiency virus-infection and discuss clinical characteristics identify prognostic factors associated non-HIV PCP. Methods Forty-six PCP who were admitted respiratory intensive care unit (ICU) between May 2018 2020 retrospectively reviewed. subjects divided into survivor non-survivor groups according patients'...
Cases of H9N2 avian influenza virus (AIV) in poultry are increasing throughout many Eurasian countries, and co-infections with other pathogens have resulted high morbidity mortality poultry. Few studies investigated the genetic factors airborne transmission which determine scope this epidemic. In study, we used specific-pathogen-free chickens housed isolators to investigate transmissibility five recombinant AIV rescued by reverse technology. The results show that A/Chicken/Shandong/01/2008...
Candida krusei attracts attention from medical professionals mainly for its intrinsic resistance to fluconazole and the limited number of drugs available treat C. vulvovaginal candidiasis. Miltefosine was demonstrated have good antifungal activity both in vitro vivo. Here, we determined susceptibility profiles 57 clinical isolates candidiasis patients assessed miltefosine against krusei. All were susceptible voriconazole itraconazole, whereas 1.8% non-wild-type phenotype amphotericin B. In...
Abstract Background Streptococcus anginosus ( S. ) was reported increased in oral squamous cell carcinoma (OSCC) tissue. The aim of this study to investigate the response cancer cells biological characteristics evoked by and its potential mechanisms. Methods growth curve concentration standard were determined, a series concentrations supernatant applied OSCC lines SCC15, then selected an optimal time CCK-8 assay. Then autophagic response, proliferative activity, cycle apoptosis, invasion...
Salmonella as an important food-borne zoonotic bacterial pathogen, infection in ducks is a recessive infection, however, it can also cause high mortality and threat to food safety. Preventing controlling the transmission of critically require rapid sensitive detection method. Full-length Salmonella-specific protein PagN was induced expressed E.coil BL21 purified antigen establish indirect enzyme-linked immunosorbent assays (iELSA) kit.The recombinant has molecular weight 43 kDa containing...
Senescence is involved in many complications of pregnancy. However, whether senescent changes are also associated with missed miscarriage has not been fully investigated.The levels p16, p21, and γH2AX, markers senescence, were measured placentas collected from women by immunohistochemistry Western blotting. Levels misfolded proteins or normal first-trimester placenta that had treated H2O2 (100 μM) extracellular vesicles (EVs) placental explant culture fluorescent compound, thioflavin-T. The...
The aim of this study was to evaluate effects microbial aerosols on immune function ducks and shed light the establishment aerosol concentration standards for poultry. A total 1800 1-d-old cherry valley were randomly divided into five groups (A, B, C, D, E) with 360 in each. To obtain objective data, each group had three replications. Concentrations airborne bacteria, fungi, endotoxin different created by controlling ventilation bedding cleaning frequency. Group control hygienic conditions...
Reports on negative results of metagenomic next-generation sequencing (mNGS) are scarce. We aimed to explore the diagnostic value in bronchoalveolar lavage fluid (BALF) mNGS and how deal with patients severe respiratory disease.A retrospective analysis was performed suspected community-acquired pneumonia who were admitted intensive care unit First Affiliated Hospital Zhengzhou University from January 2020 December 2021. According final diagnosis as reference standard, divided into a true...
Machine learning (ML) has been extensively involved in assistant disease diagnosis and prediction systems to emancipate the serious dependence on medical resources improve healthcare quality. Moreover, with booming of pre-training language models (PLMs), application prospect promotion potential machine methods relevant field have further inspired. PLMs recently achieved tremendous success diverse text processing tasks, whereas limited by significant semantic gap between corpus structured...
Abstract Periodontal bone regeneration using marrow mesenchymal stem cell (BMMSC) transplantation is a promising method; however, the method for osteogenic differentiation of BMMSCs needs to be improved. In this research, we sought identify roles let‐7a in osteogenesis and provide potential periodontal regeneration. Our previous study revealed that Fas/FasL target let‐7a. study, demonstrated overexpression significantly enhanced BMMSC‐CAs both vitro vivo. Mechanistically, upregulation rfas /...
Abstract Background To evaluate the performance of simultaneous amplification and testing (SAT) assay for detection group B Streptococcus (GBS) in maternal vaginal perianal swabs compared with real-time polymerase chain reaction (RT-PCR). Methods We obtained from 1474 pregnant women at Obstetrics Gynecology Hospital Fudan University (Shanghai, China) between April 2023 June 2023. Vaginal were collected 35–37 weeks gestation. Swabs tested GBS simultaneously by using SAT RT-PCR, a comparative...
To assess the changes in maternal-fetal outcomes a nonepidemic designated hospital during COVID-19 pandemic.