A5026577634- Neural dynamics and brain function
- stochastic dynamics and bifurcation
- EEG and Brain-Computer Interfaces
- Nonlinear Dynamics and Pattern Formation
- Neuroscience and Neural Engineering
- Neural Networks and Applications
- Functional Brain Connectivity Studies
- Advanced Memory and Neural Computing
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Sarcoma Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Human-Automation Interaction and Safety
- Tactile and Sensory Interactions
- Muscle activation and electromyography studies
- Cognitive Science and Mapping
- Motor Control and Adaptation
- Genomic variations and chromosomal abnormalities
- Retinal Development and Disorders
- Probabilistic and Robust Engineering Design
- Neural and Behavioral Psychology Studies
- Blind Source Separation Techniques
- Data Management and Algorithms
Beijing Information Science & Technology University
2024
Jingdong (China)
2021-2024
East China University of Science and Technology
2014-2023
Hangzhou Dianzi University
2017-2023
ZheJiang Academy of Agricultural Sciences
2023
Taipei Veterans General Hospital
2023
Southwest Jiaotong University
2020
University College London
2009-2017
Great Ormond Street Hospital
2009-2017
Great Ormond Street Hospital for Children NHS Foundation Trust
2015
Thirty Schiff bases of hydroxysemicarbazide (Ar−CHNNHCONHOH) have been synthesized and tested against L1210 murine leukemia cells. The IC50 values were found to be in a range from 2.7 × 10-6 9.4 10-4 M. A total 17 out the 30 compounds had higher inhibitory activities than hydroxyurea (an anticancer drug currently used for treatment melanoma, leukemia, ovarian cancer) Six with micromolar 11- 30-fold more potent (IC50 = 8.2 10-5 M). partition coefficient (log P) ionization constants (pKa)...
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) its preparations are currently used to treat patients suffering from heart attack, angina pectoris, stroke some other conditions. use of S. has been increasing the management stroke. Pharmacological examinations showed that plant active ingredients, tanshinones salvianolic acids, have anticoagulant, vasodilatory, increased blood flow,...
In order to detect human operator performance degradation or breakdown, this paper proposes an adaptive support vector machine-based method classify mental workload (MWL) into few discrete levels based on psychophysiological measures. Electroencephalogram, electrocardiogram, and electrooculography signals were recorded continuously while the was performing safety-critical process control operations in a simulated human-machine system. coarse-grained analysis, exponential smoothing (AES)...
With the prevalence of positioning techniques, a prodigious number spatio-temporal data is generated constantly. To effectively support sophisticated urban applications, e.g., location-based services, based on data, it desirable for an efficient, scalable, update-enabled, and easy-to-use management system.This paper presents JUST, i.e., JD Urban Spatio-Temporal engine, which can efficiently manage big in convenient way. JUST incorporates distributed NoSQL store, Apache HBase, as underlying...
Trajectory data is very useful for many urban applications. However, due to its spatio-temporal and high-volume properties, it challenging manage trajectory data. Existing management frameworks suffer from scalability problem, only support limited queries. This paper proposes a holistic distributed NoSQL storage engine, TrajMesa, based on GeoMesa, an open-source indexing toolkit TrajMesa adopts novel schema, which reduces the size tremendously. We also devise key designs, propose bunch of...
By re-examining the neuronal activity energy model, we show inadequacies in current understanding of consumption associated with neuron activity. Specifically, computationally that a first absorbs and then consumes during firing action potential, this result cannot be produced from any models or biological neural networks. Based on finding, provide an explanation for observation when neurons are excited brain, blood flow increases significantly while incremental oxygen is very small. We can...
Based on the Hodgkin-Huxley model, present study established a fully connected structural neural network to simulate activity and energy consumption of cortex by coding theory. The numerical simulation result showed that periodicity distribution was positively correlated number neurons coupling strength, but negatively signal transmitting delay. Moreover, relationship between feature synchronous oscillation network, which when proportion negative in power curve high, apparent. In addition,...
Brief bursts of high-frequency spikes are a common firing pattern neurons. The cellular mechanisms bursting and its biological significance remain matter debate. Focusing on the energy aspect, this paper proposes neural calculation method based Chay model bursting. flow ions across membrane neuron with or without current stimulation power which contributes to change transmembrane electrical potential analyzed here in detail. We find that during depolarization becomes negative, was also...
Numerous experiments have found that the behavioral characteristics of major depressive disorder (MDD) animals are usually associated with abnormal neural activity patterns and brain energy metabolism. However, relationship among characteristics, metabolism remains unknown. In this paper, we computationally investigated relationship, especially studied how coding changed in MDD brains, VTA-NAc-mPFC dopaminergic pathway reward system based on our biological network model calculation model....
Abstract Metastasis is a major factor associated with poor prognosis in cancer, but little known of its molecular mechanisms. Although the clinical behavior soft tissue sarcomas highly variable, few reliable determinants outcome have been identified. New markers that predict outcome, particular ability primary tumors to develop metastatic tumors, are urgently needed. Here, we chosen leiomyosarcoma as model for examining relationship between gene expression profile and development metastasis...
A literature survey was conducted on herbs, their preparations and ingredients with reported liver protection activities, in which a total of 274 different species hundreds active have been examined. These can be roughly classified into two categories according to activities: (1) the main ingredients, such as silybin, osthole, coumarin, glycyrrhizin, saikosaponin A, schisandrin flavonoids; (2) supporting substances, sugars, amino acids, resins, tannins volatile oil. Among them, some...
Electrical activity is the foundation of neural system. Coding theories that describe electrical by roles action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions energy method, which more global and economical. In this study, we clearly defined calculated supply consumption based on Hodgkin-Huxley model, during firing potentials subthreshold activities using ion-counting power-integral model. Furthermore, analyzed properties...
Based on the H–H equation, this study has proposed calculation and analysis of energy expenditure for a single neuron which is activated at sup-threshold subthreshold, as well criterion neurons was maximum power sodium ion pump. Results showed that not only electrophysiological activities were strictly restricted by levels in brain, but also had dual nature, meaning subthreshold mainly with expenditure, while both absorption expenditure. These new findings compared novel neuro-biophysical...
Rodent animal can accomplish self-locating and path-finding task by forming a cognitive map in the hippocampus representing environment. In classical model of map, system (artificial animal) needs large amounts physical exploration to study spatial environment solve problems, which costs too much time energy. Although Hopfield's mental makes up for deficiency mentioned above, path is still not efficient enough. Moreover, his mainly focused on artificial neural network, clear physiological...
t(11;18)(q21;q21) occurs specifically in mucosa-associated lymphoid tissue (MALT) lymphoma and the translocation generates a functional API2-MALT1 fusion product that activates nuclear factor (NF)kappaB. t(11;18) positive lymphomas usually lack chromosomal aberrations microsatellite alterations frequently seen translocation-negative MALT lymphomas. To further understand their genetic differences, we investigated gastric with without by comparative genomic hybridisation. In general, both...
The identification of the temporal variations in human operator cognitive task-load (CTL) is crucial for preventing possible accidents human-machine collaborative systems. Recent literature has shown that change discrete CTL level during system operations can be objectively recognized using neurophysiological data and supervised learning technique. objective this work to design subject-specific multi-class classifier reveal complex unknown relationship between operator's task performance...
Studying neural coding through energy is a novel view. In this paper, based on previously proposed single neuron model, the correlation between consumption and parameters of cortex networks (amount neurons, coupling strength, transform delay) under an oscillational condition were researched. We found that distribution varies orderly as these change, it closely related to synchronous oscillation network. Besides, we compared method with traditional relative coefficient, which shows works...