A5101422746- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- Liver Disease and Transplantation
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Obesity, Physical Activity, Diet
- Acupuncture Treatment Research Studies
- Drug-Induced Adverse Reactions
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Pain Mechanisms and Treatments
- Sports Performance and Training
- Polysaccharides and Plant Cell Walls
- Plant Reproductive Biology
- Intracranial Aneurysms: Treatment and Complications
- Diabetes Treatment and Management
- Obesity and Health Practices
- Plant Molecular Biology Research
- Infectious Diseases and Tuberculosis
- Fungal Infections and Studies
- Surgical Simulation and Training
- HIV/AIDS Research and Interventions
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
Heilongjiang University
2020-2025
Peking Union Medical College Hospital
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023
First Affiliated Hospital of Zhengzhou University
2022
Inner Mongolia Medical University
2021
University of Akron
2016
SUNY Downstate Health Sciences University
2015
Shanghai University of Sport
2014
University of Jyväskylä
2014
"Banlangen" (Isatis indigotica Fort., indigowoad root) is the dried root of a plant in Cruciferae (Brassicaceae) family, which has been cultivated China for over 2000 years. This herb significant medicinal value and played an important therapeutic role during COVID-19 pandemic. Isatis widely China, with varying seed quality across different regions. Investigating distribution endogenous metabolites from various regions great significance its efficient utilization. In this study, 21 samples...
Objective The aim of this study was to evaluate the potential metagenomic next-generation sequencing (mNGS) for diagnosis pneumocystis pneumonia (PCP) in patients with non-human immunodeficiency virus-infection and discuss clinical characteristics identify prognostic factors associated non-HIV PCP. Methods Forty-six PCP who were admitted respiratory intensive care unit (ICU) between May 2018 2020 retrospectively reviewed. subjects divided into survivor non-survivor groups according patients'...
Aim To evaluate diagnostic performance of metagenomic next-generation sequencing (mNGS) for Pneumocystis jirovecii pneumonia (PCP), in comparison with polymerase chain reaction (PCR), Gomori methenamine silver (GMS) staining and serum 1,3-β-d-Glucan (BG) assay.Methods 52 PCP patients 103 non-pneumocystic (non-PCP) were enrolled, comparative analysis was conducted different tests. Clinical features co-pathogen characteristics reviewed.Results The sensitivity (92.3%) specificity (87.4%) mNGS...
Knowledge about the interrelationship between adiposity and systemic low-grade inflammation during pubertal growth is important in detecting early signs of obesity-related metabolic disorders. The objective study was to evaluate developmental trajectories fat mass (FM) high sensitive C-reactive protein (hsCRP) levels factors that could explain relationship FM hsCRP girls from prepuberty adulthood. This a 7.5-year longitudinal study. conducted at University Jyväskylä Sports Health Science...
Objects Imigliptin is a novel dipeptidyl peptidase-4 inhibitor. In the present study, we aimed to evaluate effects of imigliptin and alogliptin on insulin resistance beta-cell function in Chinese patients with type-2 diabetes mellitus (T2DM). Methods A total 37 T2DM were randomized receive 25 mg imigliptin, 50 placebo, (positive drug) for 13 days. Oral glucose tolerance tests conducted at baseline day 13, followed by oral minimal model (OMM). Results or treatment, compared their was...
Rationale: Microbial infection should be regarded in the differential diagnosis of neurosurgical complications after transnasal transsphenoidal pituitary microsurgery, albeit cryptococcal meningitis is rare. This article will discuss risk factors patients underwent and summary potential origins infection. Patient concerns diagnosis: Here, we report a case 37-year-old male who had microsurgery relapsing ACTH-secreting adenoma. Intervention: Standard therapy for Cryptococcus neoformans...
With immunosuppressants being widely used, Pneumocystis jirovecii pneumonia (PCP) has been increasing and could be life-threatening among HIV-negative patients. This study aimed at identifying prognostic factors of PCP in patients with nephrotic syndrome.We retrospectively investigated syndrome who were diagnosed PCP. The diagnosis was based on clinical manifestations, radiological findings, microbiological confirmatory tests. Predictors outcome determined multivariate logistic regression...
MASH is a prevalent liver disease that can progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and ultimately death, but there are no approved therapies. Leukotriene B4 (LTB4) potent pro-inflammatory chemoattractant drives macrophage neutrophil chemotaxis, genetic loss or inhibition of its high affinity receptor, leukotriene receptor 1 (BLT1), results in improved insulin sensitivity decreased hepatic steatosis. To validate the therapeutic efficacy BLT1 an inflammatory...
Abstract Background : Over the past decades, Klebsiella pneumoniae ( K. ) infections have been increasing and affected immunocompromised patients nosocomially communally, with extended-spectrum β-lactamase (ESBL) production becoming a major concern. Patients rheumatic autoimmune diseases, mostly receiving immunosuppressive therapy, are vulnerable to various infections, including . However, few investigated in this specific population. This study aimed identify factors associated ESBL...