A5100396511- Peptidase Inhibition and Analysis
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Biomarkers in Disease Mechanisms
- Lymphoma Diagnosis and Treatment
- Clusterin in disease pathology
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Autoimmune Neurological Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Cutaneous lymphoproliferative disorders research
- Wnt/β-catenin signaling in development and cancer
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Genetics and Neurodevelopmental Disorders
Peking University Shenzhen Hospital
2025
Chinese People's Liberation Army
2023
Addenbrooke's Hospital
2023
University of Cambridge
2023
Xiangya Hospital Central South University
2021
Central South University
2021
Dalian Medical University
2021
Nanjing Medical University
2020
Jiangsu Province Hospital
2020
Tongji Hospital
2019
MMP13 (matrix metallopeptidase 13) plays a key role in bone metabolism and cancer development, but has no known functions Alzheimer's disease. In this study, we used high-throughput small molecule screening SH-SY5Y cells that stably expressed luciferase reporter gene driven by the BACE1 (β-site amyloid precursor protein cleaving enzyme 1) promoter, which included portion of 5' untranslated region (5'UTR). We identified CL82198, selective inhibitor MMP13, decreased levels cultured neuronal...
Autoimmune encephalitis (AE) is a rare and recently described neuroinflammatory disease associated with specific autoantibodies. Anti-leucine-rich glioma inactivated 1 (anti-LGI1) but treatable type of AE discovered in recent years. Alzheimer's (AD) degenerative brain the most common cause dementia. AD may undergo series pathological physiological changes tissue 20 years before onset typical symptoms. The stage mild cognitive impairment (MCI) that occurs during this process, known as MCI due...
Purpose: Clinical success of precision medicine is severely limited by de novo or acquired drug resistance. It remains a clinically unmet need to treat these patients. Tumor suppressor genes (TSGs) play critical role in tumorigenesis and impact the therapeutic effect various treatments. Experimental Design: Using clinical data, vitro cell line data vivo mouse model we revealed tumor suppressive Clusterin lung cancer. We also delineated signaling cascade elicited loss function CLU NSCLC cells...
Lung cancer is one of the most aggressive tumors with high incidence and mortality, which could be classified into lung squamous cell carcinoma (LUSC) adenocarcinoma (LUAD). Overexpression Plakophilin-2 (PKP2) has been reported in multiple malignancies. However, expression function mechanism PKP2 LUAD remain illusive.Real-time PCR (RT-PCR) was conducted to assess cells tissues. An integrated analysis The Cancer Genome Atlas (TCGA) further performed. effect on proliferation invasion potential...
Purpose Gastric cancer (GC) is one of the most frequently diagnosed cancers and leading causes deaths worldwide, especially in eastern Asia China. Anti-PD-1 immune checkpoint inhibitors, Pembrolizumab Nivolumab, have been approved for treatment locally advanced or metastatic gastric gastroesophageal junction (GC/GEJC). Our study evaluated effectiveness safety anti-PD-1-based (monotherapy combination therapy) Chinese patients with GC/GEJCs a real-world setting. Methods A retrospective cohort...
Background: γδT cell lymphoma (γδ TCL) is a class of hematopoietic malignancy that expresses the γδ T receptor (TCR) with low incidence. Determining clonal proliferation cells important for diagnosis such malignancies. Few studies have used flow cytometry to detect VδTCR and its subtypes (Vδ1 Vδ2) at protein level, although it practical method determining neoplastic cells. Methods: A TCRVδ-based 10-color protocol was designed detection malignant subtype by multiparameter cytometry,...
AIM:To study the effects of chromic-P32 phosphate ( 32 P colloids) interstitial administration in Pc-3 implanted pancreatic carcinoma, and investigate its anticancer mechanism. METHODS:Ninety-eight tumor bearing nude mice were killed at different time points after injection colloids to core with observed radioactivity.The light microscopy, transmission electron microscopy (TEM) immuno-histochemistry flow cytometry used rates cell necrosis, proliferating nuclear antigen index, micro vessel...
<div>Abstract<p>Histopathologic grading of astrocytic tumors based on current WHO criteria offers a valuable but simplified representation oncologic reality and is often insufficient to predict clinical outcome. In this study, we report new tumor microarray gene expression data set (<i>n</i> = 65). We have used simple artificial neural network algorithm address human tumors, derive specific transcriptional signatures from histopathologic subtypes asses whether these...
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Objective To study the effect of low expression tumor necrosis factor receptor associated 4 (TRAF4) on invasion and migration colorectal cancer cells. Methods Immunohistochemistry was used to detect TRAF4 in clinical specimens adjacent tissues. The levels epithelial-mesenchymal transition (EMT)-related proteins [E-cadherin (E-cad), Snail Slug] were detected by Western blotting. Transwell assay examine invasive ability cells LoVo after silencing...
Abstract Background : Lung cancer is one of the most lethal cancers worldwide, but studies have shown that higher expression programmed cell death protein 1 ligand (PD-L1) in non-small lung (NSCLC), more likely it will benefit from anti-PD-L1 immunotherapy. The purpose our study was to collect and analyze abundant clinical samples order provide evidence for clinicians patients who might consider immunotherapy while jointly formulating treatment plans. Methods On hand, we obtained cases...