A5100636666- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Corneal Surgery and Treatments
- Immune Cell Function and Interaction
- Pain Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Ocular Surface and Contact Lens
- SARS-CoV-2 and COVID-19 Research
- Advanced Glycation End Products research
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- SARS-CoV-2 detection and testing
- Cholesterol and Lipid Metabolism
- Endometrial and Cervical Cancer Treatments
- Ideological and Political Education
- Congenital Diaphragmatic Hernia Studies
- Acupuncture Treatment Research Studies
- Tissue Engineering and Regenerative Medicine
- Ovarian cancer diagnosis and treatment
Heilongjiang Provincial Hospital
2013-2025
Harbin Institute of Technology
2020-2025
Shanghai Pudong New Area Gongli Hospital
2017-2025
Second Military Medical University
2013-2025
Women's Hospital, School of Medicine, Zhejiang University
2019-2024
Jiangsu Maritime Institute
2021-2024
Ocean University of China
2024
Qingdao National Laboratory for Marine Science and Technology
2024
Third Hospital of Nanchang
2024
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2021-2024
Abstract The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has affected more than eight million people. There is an urgent need to investigate how the adaptive immunity established in COVID-19 patients. In this study, we profiled immune cells of PBMCs from recovered patients with varying severity using single-cell RNA and TCR/BCR V(D)J sequencing. sequencing data revealed SARS-CoV-2-specific shuffling repertories COVID-19-induced remodeling peripheral lymphocytes....
Discriminating between idiosyncratic drug-induced liver injury (DILI) and autoimmune hepatitis (AIH) is critical yet challenging. We aim to develop validate a machine learning (ML)-based model aid in this differentiation. This multicenter cohort study utilised development set from Beijing Friendship Hospital, with retrospective prospective validation sets 10 tertiary hospitals across various regions of China spanning January 2009 May 2023. Different ML algorithms were tested using 24 routine...
Abstract Objective Bile acid ( BA ) synthesis is regulated by negative feedback end‐product inhibition, initiated farnesoid X receptors FXR s) in liver and gut. Studies on cholic CA )‐free Cyp8b1 −/− mice have concluded that a potent suppressor of synthesis. increased an enlarged pool, phenotype shared with bile‐duct‐ligated, antibiotics‐administered germ‐free mice. such induced due to reduced hormonal signalling fibroblast growth factor FGF )15 from intestine liver. A mutual finding these...
Abstract Background Stem cell therapy is a promising treatment for cerebral palsy, which refers to category of brain diseases that are associated with chronic motor disability in children. Autologous MSCs may be better source and have been studied the palsy because their functions tissue repair regulation immunological processes. Methods To assess neural stem cell–like (NSC-like) cells derived from autologous marrow mesenchymal as novel patients moderate-to-severe total 60 were enrolled this...
No therapeutics have been proven effective yet for the treatment of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). To assess efficacy and safety Triazavirin therapy COVID-19, we conducted a randomized, double-blinded controlled trial involving hospitalized adult patients with COVID-19. Participants were enrolled from ten sites, randomized into two arms study ratio 1:1. Patients treated 250 mg versus placebo three or four times day 7 d. The...
IL-10+ regulatory B (Bregs), CD4+Foxp3+ T (Tregs), and CD4+CXCR5+Foxp3+ follicular (TFR) cells regulate the progression of infection disease. This study aimed at examining how those associated with development chronic hepatitis (CHB) C (CHC) in a Chinese population.The numbers circulating Bregs, Tregs TFR 31 CHC, 58 CHB patients 22 healthy controls (HC) were examined by flow cytometry. The potential association clinical measures was analyzed.The CD5+CD19+CD1dhighIL-10+ levels serum IL-10,...
Objective: This study aimed to explore the roles of serum tumor markers for metastasis and stage non-small cell lung cancer (NSCLC). Methods: recruited 3272 NSCLC patients admitted Tianjin Union Medical Center University Cancer Institute Hospital. The predictive abilities some (carcinoembryonic antigen (CEA), squamous carcinoma (SCC-Ag), cytokeratin-19 fragment (CYFRA 21-1), neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), total prostate-specific (TPSA) carbohydrate 199...
Abstract Decellularization can reduce the immune barrier of xenotransplantation, but tissue swelling‐caused structural and functional damage remains unsolved, including corneal transparency loss after decellularization. Here, a protective decellularization strategy is developed for preparation decellularized porcine cornea (DPC), in which corneas are treated by detergent endonuclease medium with 50 mmHg colloid osmotic pressure. A nonrandomized open‐label trial conducted to evaluate clinical...
Corneal scarring is characterized by the improper deposition of extracellular matrix components and myofibroblast differentiation from keratocytes. The bromodomain-containing protein 4 (BRD4) inhibitor JQ1 has been shown to attenuate pathological fibrosis. present study aimed explore potential therapeutic effect on mechanical injury-induced mouse corneal TGFβ-induced human related mechanism. were evaluated with clinical observation fibrosis-related gene expression analysis. In mice,...
Corneal decellularization represents a promising alternative source of human donor with global shortage. Multiple methods have been developed for the preparation decellularized porcine corneal stroma. However, most strategies relied on long-time treatment to facilitate entry detergents or nucleases, which may cause irreversible ultrastructural damage. Here, we rapid method stroma through combined mild detergent sodium N-lauroyl glutamate (SLG) and supernuclease. Compared traditional methods,...
This study aims to explore the nursing effect of a multimodal pre-rehabilitation programme guided by BCW theory on elderly women patients with breast cancer.
<h3>Importance</h3> Acupoint hot compress during the early postpartum period may benefit patients after a vaginal delivery, but evidence of this effect is limited. <h3>Objective</h3> To assess whether acupoint involving abdominal, lumbosacral, and plantar regions could reduce incidence urinary retention, relieve uterine contraction pain, prevent emotional disorders, promote lactation. <h3>Design, Setting, Participants</h3> This multicenter randomized clinical trial was conducted at 12...
Abstract. Hu X, Steffensen KR, Jiang Z‐Y, Parini P, Gustafsson J‐Å, Gåfvels M, Eggertsen G (Karolinska Institutet, Huddinge, Stockholm, Sweden; Karolinska Shanghai Institute of Digestive Surgery, Ruijin Hospital, Jiao Tong University School Medicine, Shanghai, China; and Houston, TX, USA). LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile. J Intern Med 2012; 272: 452–464. Objectives. Liver X receptors (LXRs) are essential for the...
Abstract Chronic inflammation and severe dry eye are two important adverse factors for the successful transplant of cultured limbal stem cells. The aim this study was to investigate effects hyperosmotic stress (a key pathological factor in eye) on corneal epithelial cells (CESCs) wound healing. We observed that CESCs exhibited significant morphological changes when treated with interleukin-1 beta (IL-1β), tumor necrosis alpha (TNF-α), or stress. Colony-forming efficiency colony-forming size...