A5032557544- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Ocular Infections and Treatments
- Healthcare and Venom Research
- Osteoarthritis Treatment and Mechanisms
- Ocular Disorders and Treatments
- Pharmacological Effects and Assays
- Grey System Theory Applications
- Cardiovascular Health and Risk Factors
- Advanced Proteomics Techniques and Applications
- Advanced X-ray and CT Imaging
- Extracellular vesicles in disease
- Advanced Measurement and Detection Methods
- Silk-based biomaterials and applications
- Glaucoma and retinal disorders
- Advanced Algorithms and Applications
- Obesity, Physical Activity, Diet
- Cardiovascular Function and Risk Factors
- Rheumatoid Arthritis Research and Therapies
- Ultrasound and Hyperthermia Applications
Shandong Eye Hospital
2018-2025
Shandong First Medical University
2019-2025
Northeast Forestry University
2024
Zhejiang University
2024
Sir Run Run Shaw Hospital
2023-2024
Shandong University
2018-2021
Qilu Hospital of Shandong University
2019
Shandong Provincial Hospital
2018-2019
Inner Mongolia Medical University
2009
Taizhou University
2008
Hydrogels have attracted tremendous attention as favorable corneal substitutes for treating severe infectious keratitis (IK). However, current hydrogel-based were majorly designed to promote the single stage of regeneration, which falls short in meeting clinical management needs IK including multiple phases wound healing. Herein, we introduce a versatile hybrid hydrogel (SQPV) composed silk fibroin and chitosan, exhibits spatiotemporal properties drug release. The SQPV is fabricated by...
Abstract Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization corneal stroma is challenging. In this study, humanized stroma‐like adhesive patches (HCSPs) are prepared through a multi‐step process. First, polyethylene glycol diacrylate cast cured within decellularized porcine cornea (DPC) templates. The DPCs then enzymatically digested to...
Abstract Corneal injectable hydrogels represent a promising alternative to alleviate donor shortage and simplify traditional surgeries. However, most focus on repairing focal corneal defects (≤3.5 mm) leave many clinical requirements unmet. Herein, novel ion‐activated bioadhesive hydrogel (IonBAH) is designed its long‐term performance of large (6 evaluated in rabbits for 6 months. The IonBAH dual‐network composed natural extracellular matrix peptide‐modified alginate, which enables desirable...
The repair of large-diameter corneal stroma defects is a major clinical problem. Although some studies have attempted to use hydrogels damage, most these can only be used for focal stromal that are ≤3.5 mm in diameter due poor hydrogel adhesion. Here, photocurable adhesive mimics the extracellular matrix (ECM) with regard composition repairing 6 mm-diameter rabbits investigated. This ECM-like rapidly cured after light exposure, high transmittance and good mechanical properties. More...
Corneal decellularization represents a promising alternative source of human donor with global shortage. Multiple methods have been developed for the preparation decellularized porcine corneal stroma. However, most strategies relied on long-time treatment to facilitate entry detergents or nucleases, which may cause irreversible ultrastructural damage. Here, we rapid method stroma through combined mild detergent sodium N-lauroyl glutamate (SLG) and supernuclease. Compared traditional methods,...
Natural antifungal hydrogels that comprise a decellularized porcine cornea (DPC), gelatin and microspheres (MCs) containing voriconazole (Vor) were designed fabricated. The natural DPC–gelatin hydrogel was used as drug delivery vehicle for the release of Vor. This hydrogel-based system holds great promise preventing fungal keratitis infection while promoting focal corneal stromal regeneration.
Although compressed sensing (CS) accelerated cine holds immense potential to replace conventional cardiovascular magnetic resonance (CMR) cine, how use CS-based appropriately during clinical CMR examinations still needs exploring. A total of 104 patients (46.5 ± 17.1 years) participated in this prospective study. For each participant, a balanced steady state free precession (bSSFP) was acquired as reference, followed by two CS sequences with identical parameters before and after contrast...
Purpose: To produce an acellular small intestine submucosa (SIS) that would be a suitable scaffold for corneal epithelium tissue engineering.Methods: The SIS was decellularized by immersion in 0.1% (wt/vol) sodium dodecyl sulfate (SDS). efficacy of acellularization confirmed histological observation and DNA quantification. mechanical properties were evaluated uniaxial tensile testing. ELISA performed to assess the growth factor contents. cytotoxicity scaffolds extracts rabbit epithelial...
Abstract Purpose To describe the corneal calcification of acellular porcine stroma (APCS) following lamellar keratoplasty (LKP) and identify risk factors. Methods Two cases APCS were evaluated by slit‐lamp photography anterior segment optical coherence tomography (AS‐OCT). von Kossa staining scanning electron microscope/energy‐dispersive spectrometry (SEM/EDS) performed on pathologic tissue. Associated graft postoperative factors analysed. Acellular cleanliness element content after rinsing...
Corneal Regeneration In article 2300192 by Lixin Xie, Qingjun Zhou, and co-workers, a photoreactive adhesive hydrogel that mimics the extracellular matrix (mainly composed of gelatin hyaluronic acid) is designed to treat large-diameter (≥6 mm) corneal defects, which effectively promotes epithelial, stromal, neural regeneration while preventing scar formation. It also holds great improvement expansion potential in future applications, such as ophthalmic surgery, cell drug delivery, tissue...
Abstract Background The sclera is one of the most commonly used repair materials in ophthalmic plastic surgery and often for supporting, wrapping, filling, pressing during surgery. Although plays an irreplaceable role ophthalmology applications, there are many restrictive factors, such as high costs limited sources. Here, we report use a decellularized porcine (DPS) scleral reconstruction rabbit models. Methods DPS generated by hybrid decellularization protocol was characterized respect...
Background Due to its potential significantly reduce scanning time while delivering accurate results for cardiac volume function, compressed sensing (CS) has gained traction in cardiovascular magnetic resonance (CMR) cine. However, further investigation is necessary explore feasibility and impact on myocardial strain results. Materials methods A total of 102 participants [75 men, 46.5 ± 17.1 (SD) years] were included this study. Each patient underwent four consecutive cine sequences with the...
Motivation: Traditional bright-blood late gadolinium enhancement (BB-LGE) technique often obscures the visualization of endocardial LGE. In contrast, black blood overcomes this limitation but sacrifices contrast between myocardium and pool. Goal(s): By selecting specific TI (inversion time) values, gray images can be generated to achieve desired among pool, myocardium, scar tissue. Approach: We conducted a comparative analysis image quality, diagnostic confidence score, detection delayed...
Objective: To study the pathological changes of articular cartilage in process osteoarthritis induced by high-fat diet and mechanism Radix achyrandii polysaccharide on cartilage, to explore protective effect Achyrannosus achyrannosus knee so as provide effective experimental evidence for clinical treatment osteoarthritis. Methods: OA model anterior cruciate ligament transection was established obese rats diet. Thirty C57BL/6 J mice were randomly divided into normal group (CON), high fat (OA)...