A5089876826- Gout, Hyperuricemia, Uric Acid
- Case Reports on Hematomas
- Eosinophilic Disorders and Syndromes
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- Muscle and Compartmental Disorders
- Bone Metabolism and Diseases
- Spondyloarthritis Studies and Treatments
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- interferon and immune responses
- Hepatitis C virus research
- Bartonella species infections research
- Aortic Thrombus and Embolism
- Fibroblast Growth Factor Research
- Genetic Syndromes and Imprinting
- Diabetes and associated disorders
- Vasculitis and related conditions
- Transplantation: Methods and Outcomes
- Systemic Sclerosis and Related Diseases
- Pelvic floor disorders treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2016-2025
Far Eastern Memorial Hospital
2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2009
Ateliéry Tapisérií sro
2009
Systemic inflammation is involved in vascular calcification and cardiovascular disease which the leading cause of mortality rheumatoid arthritis (RA). A high level serum interleukin (IL)-6 plays a key role local systemic RA. However, underlying mechanisms remain unclear. We established human umbilical artery smooth muscle cell (HUASMC) culturing method to investigate possible IL-6 on calcification. HUASMCs were obtained from arteries healthy neonates. To detect effects, treated with...
Objective The predominant mechanism driving hyperuricemia in gout is renal uric acid underexcretion; however, the standard urate‐lowering therapy (ULT) recommendation first‐line xanthine oxidase inhibitor (XOI), irrespective of cause hyperuricemia. This comparative effectiveness clinical trial was undertaken to compare nontitrated low‐dose benzbromarone (LDBen) uricosuric XOI ULT with febuxostat (LDFeb) patients underexcretion. Methods We conducted a prospective, randomized, single‐center,...
Abstract Objectives Gout patients frequently have decreased urine pH, related to metabolic syndrome (MetS) and chronic kidney disease. Here, we aimed investigate whether the addition of alkalization urate-lowering therapy (ULT) is associated with improvements in albuminuria, gout flares or MetS outcomes men low urinary pH (pH < 6.2). Methods A prospective cohort study enrolled 385 participants starting ULT febuxostat (initially 20 mg daily, escalated 40 daily if serum urate ≥360...
Low doses of febuxostat or benzbromarone are widely used in Asian countries, but lacking studies to compare the efficacy and safety two urate-lowering drugs. To low-dose with patients primary gout, a randomized controlled, open-label trial was performed among male gout for therapy (ULT) dedicated clinic China. Randomization carried out by third-party institution according random number table. Patients were randomly assigned 1:1 group (Feb group) (20 mg daily) (Ben (25 treated 12 weeks....
Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart cherry supplements on pH has yet studied.This study aimed investigate safety supplementary citrate (TaCCi) mixture serum urate (sUA), C-reactive protein (CRP), gout flares patients initiating urate-lowering therapy (ULT), comparison sodium bicarbonate.A prospective, randomized (1:1:1),...
Hyperuricemia (HU) is a cause of gout. Clinical studies show link between HU and cardiovascular disease. However, the role soluble serum urate (SU) on atherosclerosis development remains elusive. We aimed to use new mouse model [Uricase/Uox knockout (KO)] further investigate relationship atherosclerosis. A by perivascular collar placement induced carotid was established in male Uox-KO mice. The mice had elevated SU levels enhanced inflammatory response proteins. In contrast, with showed...
BACKGROUND B lymphocyte hyperactivity is a main characteristic of systemic lupus erythematosus (SLE), and lymphocytes play prominent pathogenic role in the development progression SLE. The aim this study was to investigate Sirtuin 1 (Sirt1) lymphocytes. MATERIAL AND METHODS Mouse BaF3 transfected with Sirt1 vector or shRNA against Sirt1. Then cells viability apoptosis were respectively determined by MTT assay flow cytometry. In addition, mRNA levels three pro-inflammatory cytokines p53...
COVID-19 vaccination often triggers a constellation of transitory inflammatory symptoms. Gout is associated with several comorbidities linked to poor outcomes in COVID-19, and gout flares can be triggered by some vaccinations. We analysed the risk first 3 months after inactivated virus, whether colchicine prevent following post-COVID-19 vaccination.A clinical delivery population-based cross-sectional study was conducted Clinic at Affiliated Hospital Qingdao University between February...
Hyperuricemia can be stratified into four subtypes according to renal uric acid handling. The aim of this study was comprehensively describe the biologic characteristics (including genetic background) clinically defined hyperuricemia in two large geographically independent gout cohorts.
Objective Mechanisms underlying the adolescent‐onset and early‐onset gout are unclear. This study aimed to discover variants associated with gout. Methods We conducted whole‐genome sequencing in a discovery cohort of 905 individuals (gout onset 12 19 years) common low‐frequency single‐nucleotide (SNVs) Candidate SNVs were genotyped an 2,834 ≤30 years old), meta‐analysis was performed replication cohorts identify loci Transcriptome epigenomic analyses, quantitative real‐time polymerase chain...
Abstract Objectives The objective of this study was to develop and validate a prediction model for renal urate underexcretion (RUE) in male gout patients. Methods Men with enrolled from multicenter cohorts China were analyzed as the development validation data sets. RUE phenotype defined fractional excretion uric acid (FE UA ) <5.5%. Candidate genetic clinical features screened by least absolute shrinkage selection operator (LASSO) 10-fold cross-validation. Machine learning algorithms...
The correlation between serum creatinine and erythrocyte sedimentation rate (ESR) values clinical pathology prognosis in patients with renal injury caused by anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis were analyzed. Eighty-six ANCA-associated (AAV) treated the Affiliated Hospital of Qingdao University enrolled study. Patients assigned into an elderly group (n=45) or a non-elderly (n=41) according to age. (Scr) level was measured via sarcosine oxidase method, using...
Background The interaction of long non-coding RNAs (lncRNAs)-microRNAs (miRs) exerts crucial functions in mediating inflammatory reaction. It is still unclear whether myocardial infarction associated transcript 2 (Mirt2)-miR-377 mediates the pathogenesis Sjögren's syndrome (SS).Methods lesion model was established by stimulating salivary gland epithelial cells (SGECs) interferon gamma (IFN-γ). Mirt2- and/or miR-377-transfected SGECs, as well their negative controls, were applied to...
Introduction The central biochemical cause of gout is hyperuricemia (elevated serum urate levels). Ultrasound features monosodium (MSU) crystal deposition are common in people with asymptomatic hyperuricemia. However, it unclear whether this a precondition for the development gout. This study aims to determine ultrasound imaging evidence MSU predicts symptomatic over 5 years, who already have an increased risk due elevated concentrations (≥8 mg/dL). Methods and analysis prospective,...
Serum CA72-4 levels are elevated in some gout patients but this has not been comprehensively described. The present study profiled serum expression and verified the hypothesis that is a predictor of future flares prospective cohort.To profile expression, cross-sectional was conducted subjects with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) healthy controls. A cohort initiated to test value for predicting flares. During 6-month...
Objective To assess post‐COVID‐19 vaccination gout flare risk with differing baseline burden. Methods We prospectively studied patients infrequent or frequent flares, defined as ≤1 flare/year ≥2 flares/year, respectively. COVID‐19 vaccine‐naive managed urate‐lowering therapy between February and June 2021 were included voluntarily decided on vaccination. Participants followed for 12 weeks after enrollment first vaccine dose. Gout flares factors compared groups. Results Of 530 participants,...
Abstract Background While xanthine oxidase inhibitors target uric acid production, renal urate underexcretion is the predominant subtypes in gout. This study was to compare treatment response XOI febuxostat a gout cohort according clinical of hyperuricemia. Methods A prospective conducted efficacy and safety (initially 20 mg daily, escalating 40 daily if not at target) 644 patients with three major for 12 weeks. Hyperuricemia defined as overload subtype, or combined subtype based on UUE >...
Abstract Objective Gout flares during urate-lowering therapy (ULT) initiation are common, but predictors of these poorly understood. The aim this study was to determine whether serum CA72-4 is an independent predictor for gout ULT initiation. Methods A prospective cohort conducted between March 2021 and January 2022. Men with gout, at least one flare in the past year, three measurements previous six months were enrolled. Participants grouped according their highest recorded levels (above or...
Summary Background Gout is a polygenetic inflammatory disease. Although hundreds of genetic variants associated with gout and serum urate levels have been identified in studies adults, the pathogenesis adolescent-onset remains unclear. To better characterize landscape gout, whole genome sequencing study was done large Chinese cohort. Methods We conducted discovery cohort 905 individuals (gout onset 12-19 years) to discover common SNVs, uncommon indels gout. Candidate SNVs were replicated an...
There is an unmet need for simpler urate-lowering therapy (ULT) regimens that achieve the serum urate target and improve overall quality of gout care. We report a comparative effectiveness trial febuxostat monotherapy versus benzbromarone add-on to low-dose in specifically with combined renal underexcretion overload.
BACKGROUND: Gout is the most common inflammatory arthritis affecting 1.1% of population in mainland China with a higher prevalence coastal areas. OBJECTIVE: The purpose study was to investigate clinical outcomes following urate-lowering therapy (ULT) real-world group primary gout patients China. METHODS: Electronic medical records all (n= 1588) that visited Clinical Medical Center Affiliated Hospital Qingdao University from September 2016 February 2018 were analyzed this study. treated...